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Molecular Biomimetics: Genetic Synthesis, Assembly, and Formation of Materials Using Peptides

  • Candan Tamerler and Mehmet Sarikaya

In nature, the molecular-recognition ability of peptides and, consequently, their functions are evolved through successive cycles of mutation and selection. Using biology as a guide, it is now possible to select, tailor, and control peptide–solid interactions and exploit them in novel ways. Combinatorial mutagenesis provides a protocol to genetically select short peptides with specific affinity to the surfaces of a variety of materials including metals, ceramics, and semiconductors. In the articles of this issue, we describe molecular characterization of inorganic-binding peptides; explain their further tailoring using post-selection genetic engineering and bioinformatics; and finally demonstrate their utility as molecular synthesizers, erectors, and assemblers. The peptides become fundamental building blocks of functional materials, each uniquely designed for an application in areas ranging from practical engineering to medicine.

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1.Sarikaya, M., Tamerler, C., Jen, A.K.Y., Schulten, K., Baneyx, F., Nat. Mater. 2, 577 (2003).
2.Brown, S., Nat. Biotechnol. 15, 269 (1997).
3.Brown, S., Sarikaya, M., Johnson, E., J. Mol. Biol. 299, 725 (2000).
4.Gaskin, D.J.H., Starck, K., Vulfson, E.N., Biotechnol. Lett. 22, 1211 (2000).
5.Whaley, S.R., English, D.S., Hu, E.L., Barbara, P.F., Belcher, M.A., Nature 405, 665 (2000).
6.Li, C.M., Botsaris, G.D., Kaplan, D.L., Cryst. Growth Des. 2, 387 (2002).
7.Naik, R.R., Brott, L., Carlson, S.J., Stone, M.O., J. Nanosci. Nanotechnol. 2, 1 (2002).
8.Huang, Y., Duan, X., Cui, Y., Lauhon, L.J., Kim, K.H., Lieber, K.H.M.L., Nano Lett. 5, 1429 (2005).
9.Sarikaya, M., Tamerler, C., Schwartz, D.T., Baneyx, F., Annu. Rev. Mater. Res. 34, 373 (2004).
10.Sano, K.I., Sasaki, H., Shiba, K., Langmuir 21, 3090 (2005).
11.Dai, H., Choe, W.-S., Thai, C. K., Sarikaya, M., Traxler, B.A., Baneyx, F., Schwartz, D.T., J. Am. Ceram. Soc. 127, 15637 (2005).
12.McMillan, R.A., Howard, J., Zaluzec, N.J., Kagawa, H.K., Mogul, R., Li, Y.F., Paavola, C.D., Trent, J.D., J. Am. Chem. Soc. 127, 2800 (2005).
13.Gao, X., Yang, L., Petros, J.A., Marshall, F.F., Simons, J.W., Nie, S., Curr. Opin. Biotechnol. 16, 63 (2005).
14.Douglas, T., Young, M., Science 312, 873 (2006).
15.Slocik, J.M., Moore, J.T., Wright, D.W., Nano Lett. 7, 1054 (2007).
16.Pons, T., Medintz, I.L., Sapsford, K.E., Higashiya, S., Grimes, A.F., English, D.S., Mattoussi, H., Nano Lett. 7, 3157 (2007).
17.Mirkin, C.A., Letsinger, R.L., Mucic, R.C., Storhoff, J.J., Nature 382, 607 (1996).
18.Niemeyer, C.M., Angew. Chem. Int. Ed. 40, 4128 (2001).
19.Whiley, B.J., J. Phys. Chem. 15666 (2006).
20.Sönnichensen, C., Reinhard, B.M., Liphardt, J., Alivisatos, A.P., Nat. Biotechnol. 23, 741 (2005).
21.Donhauser, Z.J., Mantooth, B.A., Kelly, K.F., Bumm, L.A., Monnell, J.D., Stapleton, J.J., Price, D.W. Jr, Rawlett, A.M., Allara, D.L., Tour, J.M., Weiss, P.S., Science 292, 2303 (2001).
22.Cui, Y., Lieber, C.M., Science 291, 851 (2001).
23.Brown, A.R., Jarrett, C.P., de Leeuw, D.M., Matters, M., Synth. Met. 88, 37 (1997).
24.Ma, H., Zin, M.T., Zareie, M.H., Kang, M.-S., Kang, S.H., Kim, K.S., Reed, B.W., Tamerler, C., Sarikaya, M., Jen, A.K.-Y., J. Nanosci. Nanotechnol. 7 (8), 249 (2007).
25.Daniel, M.-C., Astruc, D., Chem. Rev. 104, 293 (2004);
Ouyang, M., Awscholom, D.D., Science 301, 1024 (2003).
26.Branden, C.-I., Tooze, J., Intruduction to Protein Structure (Garland, New York, 1999).
27.Petrouna, I.P., Arnold, F.H., Curr. Opin. Biotechnol. 11, 325 (2000).
28.Sarikaya, M., Proc. Natl. Acad. Sci. U.S.A. 96, 14183 (1999).
29.Lowenstam, H.A., Weiner, S., On Biomineralization (Oxford University Press, 1988).
30.Mann, S., Ed., Biomimetic Materials Chemistry (VCH, New York, 1996).
31.Sarikaya, M., Aksay, I.A., Eds., Biomimetics: Processing of Materials (AIP, New York, 1996).
32.Schultze, S., Harauz, G., Beveridge, T.I., J. Bacteriol. 174, 7971 (1992).
33.Frankel, R., Iron Biominerals (Plenum, New York, 1991).
34.Klaus, T., Joerger, R., Olsson, E., Granqvist, C.-G., Proc. Natl. Acad. Sci. U.S.A. 96, 13611 (1999).
35.Andersen, S.O., Hojrup, P., Roepstorff, P., Insect Biochem. Mol. Biol. 25, 153 (1995).
36.Berman, A., Addadi, L., Weiner, S., Nature 331, 546 (1988).
37.Sarikaya, M., Fong, H., Sunderland, N., Flinn, B.D., Mayer, G., J. Mater. Res. 16, 1420 (2001).
38.Cariolou, M.A., Morse, D.E., J. Comp. Biol. 157, 717 (1988).
39.Jackson, A.P., Vincent, J.F.V., Turner, R.M., Proc. R. Soc. London, Ser. B 234, 415 (1988).
40.Sarikaya, M., Gunnison, K.E., Yasrebi, M., Aksay, I.A., MRS Symp. Proc., Rieke, P.C., Ed., 174, 109 (MRS, Pittsburgh, PA, 1990).
41.Sarikaya, M., Aksay, I.A., in Results and Problems in Cell Differentiation, Case, S.T., Ed., 19, 1 (Springer, New York, 1992).
42.Mann, S., Nature 332, 119 (1988).
43.Weiner, S., Addadi, L., J. Mater. Chem. 7, 689 (1997).
44.Aksay, I.A., Baer, E., Sarikaya, M., Tirrell, T., Eds., MRS Proc. 255 (MRS, Pittsburgh, PA, 1994).
45.Hogan, B.L.M., Genes Dev. 10 (13), 1580 (1996).
46.Fong, H., White, S.N., Paine, M.L., Luo, W., Snead, M.L., Sarikaya, M., J. Bone Miner. Res. 18, 2052 (2003).
47.Glimcher, M., Nimni, M., Connect. Tissue Res. 27, 73 (1992).
48.Hull, D., Introduction to Composite Materials (Pergamon, New York, 1981).
49.Termine, J.D., Belcourt, A.B., Christner, P.J., Conn, K.M., Nylen, M.U., J. Biol. Chem. 255 (20), 9760 (1980).
50.Paine, M.L., Snead, M.L., J. Bone Miner. Res. 12, 221 (1996).
51.Fong, H., Sarikaya, M., White, S.N., Snead, M.L., J. Mater. Sci. Eng., C 7, 119 (2000).
52.Lagerstom, M., Dahl, N., Nakahori, Y., Nakagome, Y., Backman, B., Landegren, U., Pettersson, U., Genomics 10 (4), 971 (1991).
53.Ball, P., Nature 409, 413 (2001).
54.Seeman, N.C., Belcher, A.M., Proc. Natl. Acad. Sci. U.S.A. 99, 6452 (2002).
55.Tamerler, C., Sarikaya, M., Acta Biomater. 3, 289 (2007).
56.Naik, R.R., Stringer, S.J., Agarwal, G., Jones, S.E., Stone, M.O., Nat. Mater. 1, 169 (2002).
57.Mao, C., Flynn, C.E., Hayhurst, A., Sweeney, R., Qi, J., Georgiou, G., Iverson, B., Belcher, A.M., Proc. Natl. Acad. Sci. U.S.A. 100, 6946 (2003).
58.Sano, K., Yoshii, S., Yamashita, I., Shiba, K., Nano Lett. 7, 3200 (2007).
59.Klem, M.T., Willits, D., Solis, D.J., Belcher, A.M., Young, M., Douglas, T., Adv. Funct. Mater. 15, 1489 (2005).
60.Zin, M.T., Munro, A.M., Gungormus, M., Wong, N.Y., Ma, H., Tamerler, C., Ginger, D. S., Sarikaya, M., Jen, A.K.-Y., J. Mater. Chem. 17, 866 (2007).
61.Smith, G.P., Petrenko, A., Chem. Rev. 97, 391 (1997).
62.Stahl, S., Uhlen, M., Trends Biotechnol. 15 (5), 185 (1997).
63.Benhar, I., Biotechnol. Adv. 19, 1 (2001).
64.Amstatz, P., Forrer, P., Zahnd, C., Plückthun, C.A., Curr. Opin. Biotechnol. 12, 400 (2001).
65.Wittrup, K.D., Curr. Opin. Biotechnol. 12, 395 (2001).
66.Ueda, M., J. Mol. Catal. B: Enzym. 28, 139 (2004).
67.Thai, C.K., Dai, H.X., Sastry, M.S.R., Sarikaya, M., Schwartz, D.T., Baneyx, F., Biotechnol. Bioeng. 87, 129 (1994).
68.Tamerler, C., Oren, E.E., Duman, M., Venkatasubramanian, E., Sarikaya, M., Langmuir 22, 7712 (2006).
69.Sano, K., Shiba, K., J. Am. Chem. Soc. 125, 14234 (2003).
70.Kulp, J.L., Sarikaya, M., Evans, J.S., J. Mater. Chem. 14, 2325 (2004).
71.Oren, E.E., Tamerler, C., Sarikaya, M., Nano Lett. 5 (3), 415 (2005).
72.Barth, B.V., Constantini, G., Kern, K., Nature 437, 671 (2005).
73.Kroger, N., Deutzman, R., Sumper, M., Science 286, 1129 (1999).
74.Gaskin, D.J.H., Strack, K., Vulfson, E.N., Biotechnol. Lett. 22, 1211 (2000).
75.Cha, J.N., Shimizu, K., Zhou, Y., Christiansen, S.C., Chmelka, B.F., Stucky, G.D., Morse, D.E., Proc. Nat. Acad. Sci. U.S.A. 96, 361 (1999).
76.Ratner, B., Schoen, F., Hoffman, A., Lemons, J., Biomaterials Science: Introduction to Materials in Medicine (Academic Press, San Diego, 1996).
77.Mrksich, M., Curr. Opin. Chem. Biol. 6, 794 (2002).
78.Pauling, L., Nature 24 (10), 1375 (1946).
79.Barth, J.V., Weckesser, J., Trimarchi, G., Vladimirova, M., De Vita, A., Cai, C., Brune, H., Gunter, P., Kern, K., J. Am. Chem. Soc. 124, 7991 (2002).
80.Tomasio, S.D., Walsh, T.R., Mol. Phys. 105, 221 (2007).
81.Evans, J.S., Curr. Opin. Colloid Interface Sci. 8, 48 (2003).
82.Oren, E.E., Tamerler, C., Sahin, D., Hnilova, M., Seker, U.O.S., Sarikaya, M., Samudrala, R., Bioinformatics 23, 2816 (2007).
83.Seker, O.U.S., Wilson, B., Dincer, S., Kim, I.W., Oren, E.E., Evans, J.S., Tamerler, C., Sarikaya, M., Langmuir 23, 7895 (2007).
84.Jung, L.S., Campbell, C.T., Chinowsky, T.M., Mar, M.N., Yee, S.S., Langmuir 14, 5636 (1988).
85.Czenderna, A.W., Lu, C., Applications of Piezoelectric Quartz Crystal Microbalances, Methods and Phenomena (Elsevier, New York, 1984).
86.Bailey, L.E., Kambhampati, D., Kanazawa, K.K., Knoll, W., Frank, C.W., Langmuir 18, 479 (2002).
87.Whitesides, G.M., Mathias, J.P., Seto, C.T., Science 254, 1312 (1991).
88.Schreiber, R., Prog. Surf. Sci. 65, 151 (2000).
89.Roukes, M.L., Understanding Nanotechnology (Warner Books, New York, 2002).
90.Ratner, M., Ratner, D., Nanotechnology (Prentice Hall, Upper Saddle River, NJ, 2003).
91.Cutler, P., Proteomics 3, 3 (2003).
92.Zhang, S., Nat. Biotechnol. 21, 1171 (2003).
93.Tamerler, C., Duman, M., Oren, E.E., Gungormus, M., Xiong, X., Kacar, T., Parviz, B.A., Sarikaya, M., Small 2, 1372 (2006).
94.Kacar, T., So, C., Tamerler, C., Sarikaya, M., J. MSE-C (2008) in press.
95.Gungormus, M., Fong, H., Kim, I.W., Evans, J.S., Tamerler, C., Sarikaya, M., Biomacromole-cules (2008) in press.
96.Parviz, B.A., Trends in Microbiol. 14 (9), 373 (2006).
97.Xia, Y.N., Halas, N.J., MRS Bull. 30, 338 (2005).
98.Prasad, P.N., Biomaterials and Nanophotonics (Wiley, Hoboken, NJ, 2004).
99.Hartgerink, J.D., Beniash, E., Stupp, S.I., Science 294, 1684 (2001).
100.Temlin, M.F., Stoll, D., Schrenk, M., Trends Biotechnol. 20, 160 (2002).
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MRS Bulletin
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