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An Investigation of the Release Properties of a Cationic Drug From a Hydrophobic Polyanhydride Matrix as a Function of Dissolution Medium

Published online by Cambridge University Press:  15 February 2011

E. J. Ginsburg ,
T. D. Stultz ,
D. A. Stephens ,
D. Robinson ,
Y. Tian ,
R. M. LIU ,
X. Gao ,
L. C. Li ,
J. E. Quick  and
H.-C. Chang
E. J. Ginsburg
Affiliation:
Advanced Drug Delivery, Hospital Products Division, Abbott Laboratories, Abbott Park, IL 60064
T. D. Stultz
Affiliation:
Pharmaceutical Products Division, Abbott Laboratories, Abbott Park, IL 60064
D. A. Stephens
Affiliation:
Advanced Drug Delivery, Hospital Products Division, Abbott Laboratories, Abbott Park, IL 60064
D. Robinson
Affiliation:
Advanced Drug Delivery, Hospital Products Division, Abbott Laboratories, Abbott Park, IL 60064
Y. Tian
Affiliation:
Advanced Drug Delivery, Hospital Products Division, Abbott Laboratories, Abbott Park, IL 60064
R. M. LIU
Affiliation:
Advanced Drug Delivery, Hospital Products Division, Abbott Laboratories, Abbott Park, IL 60064
X. Gao
Affiliation:
Advanced Drug Delivery, Hospital Products Division, Abbott Laboratories, Abbott Park, IL 60064
L. C. Li
Affiliation:
Advanced Drug Delivery, Hospital Products Division, Abbott Laboratories, Abbott Park, IL 60064
J. E. Quick
Affiliation:
Current Address: Univ. of Iowa, College of Pharmacy, Div. of Pharmaceutics, Iowa City, IA 52240
H.-C. Chang
Affiliation:
Advanced Drug Delivery, Hospital Products Division, Abbott Laboratories, Abbott Park, IL 60064
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Abstract

The dissolution of a drug delivery system consisting of gentamicin sulfate in a hydrophobic polyanhydride matrix has been examined. The in vitro release of gentamicin is a function of the composition of the dissolution medium, with slower release in pH 7.4 buffer than in unbuffered water. This is consistent with an anion exchange taking place under conditions in which carboxylate polymer chain-ends form a poorly soluble salt with gentamicin, and sulfate is released into solution. Results of additional experiments probing this model are digeussed.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 550: Symposium GG/HH/II – Biomedical Materials-Drug Delivery, Implants and Tissue Engr , 1998 , 35
Copyright
Copyright © Materials Research Society 1999

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References

1. Gustilo, R. B.; Leagogo, L. A. C. in Orthopaedic Infection edited by Gustilo, R. B.. Gruninger, R. P., Tsukayama, D. T. (W. B. Saunders Publishers, Philadelphia, 1989), pp. 224–242.Google Scholar
2. Lew, D. P. and Waldvogel, F. A., New England J. of Med. 336 (14), 999–107 (1997).Google Scholar
3. Begg, E. J. and Barclay, M. L., Brit. J. of Clin. Pharmacology 39 (6), 597–603 (1995).Google Scholar
4. Gruninger, R. P., Tsukayama, D. T., Wicklund, B., in Orthopaedic Infection edited by Gustilo, R. B., Gruninger, R. P., Tsukayama, D. T. (W.B. Saunders Publishers, Philadelphia, 1989), pp. 66–74.Google Scholar
5. Newest Knowledge of Treatment for Bone Infection: Antibiotic-Impregnated Beads. edited by Seligson, D. and Henry, S. L. (J. B. Lippincott Company, Philadelphia) Section 1: Symposium, Clin. Orthop. and Rel. Res. 295, 2–118 (1993).Google Scholar
6. Mauduit, J., Bukh, N., Vert, M., J. Control. Rel. 23, 221–230 (1993).Google Scholar
7. Zhang, X., Wyss, U. P., Pichora, D., Goosen, M. F. A., J. Pharm. Pharmacol. 46, 718–724 (1994).Google Scholar
8. Meyer, J. D., Falk, R. F., Kelly, R. M., Shively, J. E., Withrow, S. J., Dernell, W. S., Kroll, D. J., Randolph, T. W., Manning, M. C., J. Pharm. Sci. 87 (9), 1149–1154 (1998).Google Scholar
9. Price, J. S., Tencer, A. F., Arm, D. M., Bohach, G. A., J. Biomed. Mat. Res. 30, 281–286 (1996).Google Scholar
10. Laurencin, C. T., Ibim, S. E. M., Langer, R. S., in Biomed. Appl. Synth. Biodegrad. Polym., edited by Hollinger, J. O. (CRC Publishers, Boca Raton, 1995), pp 59–102.Google Scholar
11. Domb, A. J., Amselem, S., Langer, R., Maniar, M. in Biomed. Polym., edited by Shalaby, S. W. (Hanser Publishers, Munich, 1994), pp. 69–96.Google Scholar
12. Laurencin, C. T., Gerhart, T., Witschger, P., Satcher, R., Domb, A., Rosenberg, A. E., Hanff, P., Edsberg, L., Hayes, W., Langer, R., J. Orthop. Res. 11 (2), 256–262 (1993).Google Scholar
13. Maniar, M., Domb, A., Xie, X., Skacel, P., Rock, M., Green, M., Proceed. Intern. Symp. Control. Rel. Bioact. Mater., 19, 317–318 (1992).Google Scholar
14. Nelson, C. L., Hickmon, S. G., Skinner, R. A., J Orthop. Res., 15 (2), 249–55 (1997).Google Scholar
15. Domb, A. J., Maniar, M., J. Polym. Sci: Part A: Polym. Chem. 31, 1275–1285 (1993).Google Scholar
16. Hanes, J., Chiba, M., Langer, R., Proceed. Intern. Symp. Control. Rel. Bioact. Mater., 21ST, 877–8 (1994).Google Scholar
17. Dang, W., Saltzman, W. M., J. Biomater. Sci., Polymer Edn. 6 (3), 297–311 (1994).Google Scholar
18. Attawia, M. A., Uhrich, K. E., Botchwey, E., Fan, M., Langer, R., Laurencin, C. T., Biomed, C. T. J.. Mater. Research 29, 1233–1240 (1995).Google Scholar
19. Leong, K. W., Amore, P. D', Marietta, M., Langer, R., J. Biomed. Mater. Research 20, 51–64 (1986).Google Scholar
20. Shieh, Tamada, L., Tabata, J., Domb, Y., Langer, A., R. J. Controlled Rel. 29, 73–82, (1994).Google Scholar
21. Shastri, V., Tarcha, P., Padera, R., Marini, R., Kirdhain, S., and Langer, R., “Osteocompatibility of Photopolymerizable Anhydrides,” Proceedings of the Materials Research Society, April 13-17, 1998, San Francisco. In Press.Google Scholar
22. Brem, H., Langer, R., Science & Medicine, 52–61 (July/August 1996).Google Scholar
23. Shieh, L., Tamada, J., Chen, I., Pang, J., Domb, A., Langer, R., J. Biomed. Mater. Research 28, 1465–1475 (1994).Google Scholar
24. Park, E.-S., Maniar, M., Shah, J. C., J. Controlled Release 48, 67–78, (1997).Google Scholar
25. United States Pharmacopeia, Twenty-Third Revision (United States Pharmacopeial Convention, Rockville, MD, 1997), p. 702.Google Scholar
26. Domb, A. J., Turovsky, L., Nudelman, R., Pharm. Res. 11 (6), 865–868 (1994).Google Scholar
27. Stephens, D. et al. , Manuscript in Preparation.Google Scholar
28. Stephens, D., Nuss, M., Robinson, D., Liu, R. M., Tian, Y., Chang, H. C., Li, L., Tarcha, P., presented at Surfaces in Biomaterials '98, Tucson, AZ, September. 1998.Google Scholar
29. Mäder, K., Crémmilleux, Y., Domb, A. J., Dunn, J. F., Swartz, H. M., Pharm. Res. 14 (6), 820–826 (1997).Google Scholar
30. Park, E.-S., Maniar, M., Shah, J. C., J. Controlled Release 52, 179–189, (1998).Google Scholar
31. Göpferich, A., Schedl, L., Langer, R., Polymer 37 (17), 3861–3869 (1996).Google Scholar
32. Mauduit, J.. Bukh, N., Vert, M., J. Control. Rel. 23, 209–220 (1993).Google Scholar