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Comparison of Osteoconduction in Porous Implants of Co-Cr-Mo, Vitreous Carbon, Silicone Rubber and Hydroxyapatite in Rabbit Bone Defects

Published online by Cambridge University Press:  26 February 2011

Edwin C. Shors ,
Gene W. White  and
George Kopchok
Gene W. White
Affiliation:
Interpore International, 18008 Skypark Circle, Irvine, CA 92714;
George Kopchok
Affiliation:
Harbor/UCLA Medical Center, 1000 W. Carson, Torrance, CA 90509
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Abstract

There is a need for new materials which attach to bone. Attachment can occur through bioactive surfaces or porosity. The Replamineform process can be used to produce polymers, metals and ceramics with these properties. In this study, porous implants were manufactured in cobalt-chromemolybdenum (Co-Cr-Mo) vitreous carbon and silicone rubber. The pores were 200 pm in diameter and fully interconnected. The biocompatibility and osteoconduction of these materials was compared to porous hydroxyapatite (Interpore 200 HA). In 10 rabbits, blocks (2mm×3mm×5mm) of each material were implanted subperiosteally onto the femur, or rods (5mm D×10 L) were press-fit into unicortical defects of the proximal tibia. Explants were harvested at 1–6 months, sectioned midsagitally and embedded in plastic for histomorphometry using SEM or bright field microscopy. Bone grew up to and into all implants by two months. However, implants of porous Co-Cr-Mo, vitreous carbon and silicone rubber had less bone than implants of hydroxyapatite. Also, bone formed in direct apposition to hydroxyapatite, but secondly incorporated the other materials. Moreover, implants containing hydroxyapatite in the pores of the Co-Cr-Mo induced more complete and intimate bone ingrowth. This study demonstrates the potential for bone ingrowth and bonding into a range of biocompatible materials with interconnected porosity and the superior osteconduction of porous hydroxyapatite.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 110: Symposium M – Biomedical Materials and Devices , 1987 , 547
Copyright
Copyright © Materials Research Society 1988

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