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Controlled Multi-Stage Self-Assembly of Vesicles

Published online by Cambridge University Press:  15 February 2011

Scotr A. Walker ,
S. Chiruvolu ,
J. A. Zasadzinski ,
F.-J. Schmitt  and
J. N. Israelachvlli
Scotr A. Walker
Affiliation:
Dept. of Chemical Engineering, University of California, Santa Barbara, CA 93106, USA
S. Chiruvolu
Affiliation:
Dept. of Chemical Engineering, University of California, Santa Barbara, CA 93106, USA
J. A. Zasadzinski
Affiliation:
Dept. of Chemical Engineering, University of California, Santa Barbara, CA 93106, USA
F.-J. Schmitt
Affiliation:
Dept. of Chemical Engineering, University of California, Santa Barbara, CA 93106, USA
J. N. Israelachvlli
Affiliation:
Dept. of Chemical Engineering, University of California, Santa Barbara, CA 93106, USA
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Abstract

The association of lipid or surfactant molecules into spherical vesicles in solution constitutes a primary self-assembly process, although typical vesicles are not the equilibrium form of aggregation for most lipids. Such meta-stable vesicles can undergo a secondary self-assembly into higher order structures in a controlled and reversible manner by means of site-specific ligandreceptor coupling. Cryo-electron microscopy shows these structures to be composed of tethered vesicles in their original, unstressed state. In contrast, vesicles aggregated by non-specific forces are deformed. In this work, we show that equilibrium vesicles can also undergo a secondary selfassembly via ligand-receptor interactions, as evidenced by freeze-fracture electron microscopy. Such site-specific vesicle aggregation provides a practical mechanism for the production of stable, yet controllable, microstructured materials.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 372: Symposium W1 – Hollow and Solid Spheres and Microspheres--Science and Technology , 1994 , 95
Copyright
Copyright © Materials Research Society 1995

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