Hostname: page-component-848d4c4894-2pzkn Total loading time: 0 Render date: 2024-06-04T23:31:14.408Z Has data issue: false hasContentIssue false

β-Glycosylamide Glycopolymers: Synthesis, Physical Properties, Chemical and Enzymatic Stability

Published online by Cambridge University Press:  21 February 2011

Wayne Spevak
Affiliation:
Center for Advanced Materials, Lawrence Berkeley Laboratory, Berkeley, CA 94720
Frangois D. Tropper
Affiliation:
Center for Advanced Materials, Lawrence Berkeley Laboratory, Berkeley, CA 94720
Get access

Abstract

A method is described for the preparation β-glycosylamide monomers from reducing carbohydrates. The glycosylamide monomers were copolymerized with acrylamide to formhigh molecular weight, water soluble polymers. The chemical and enzymatic stability of the β-N-glycosidic linkage was investigated. In addition, the glycopolymers were characterized by their interactions with lectins.

Type
Research Article
Copyright
Copyright © Materials Research Society 1995

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1. Lee, Y.C., Lee, R.T., Neoglycoconjiugates: Preparation and Applications, (Academic Press, 1994).Google Scholar
2. Methods in Enzymology: Neoglycoconiugates. Part A. Synthesis, vol.242, edited by Lee, Y.C. and Lee, R.T. (Academic Press, 1994).Google Scholar
3. Methods in Enzymology: Neoglycoconiugates. Part B. Biomedical Applications, vol.247, edited by Lee, Y.C. and Lee, R.T. (Academic Press, 1994).Google Scholar
4. Tropper, F.D., Bednarski, M.D., in Bioorganic Chemistry: Carbohydrates, edited by Hecht, S. (Oxford University Press, in press), Chap. 10.Google Scholar
5. Roy, R., in Modern Methods in Carbohydrate Synthesis, edited by Khan, S.H. and O'Neil, R. (Harwood Academic Publishers, Amsterdam, 1995), p. 378.Google Scholar
6. Roy, R., Tropper, F.D., Romanowska, A., Bioconjugate Chem. 3, 256, (1992).Google Scholar
7. Roy, R., Andersson, F.O., Harms, G., Kelm, S., Schauer, R., Angew. Chem. Int. Ed. Engl. 31, 1478 (1992).Google Scholar
8. Kallin, E., Lönn, H., Norberg, T., Elofsson, M., J. Carbohydr. Chem. 8, 597, (1989).Google Scholar
9. Kallin, E., Methods in Enzymology. 242, 221, (1994).Google Scholar
10. Roy, R., Tropper, F.D., Glycoconj. J. 5, 203, (1988).Google Scholar
11. Bochkov, A.F., Zaikov, G.E., Chemistry of the O-glycosidic Bond: Formation and Cleavage, translation editor Schuerch, C. (Pergamon Press, New York, 1979).Google Scholar
12. Wong, C.-H., Whitesides, G.M., Enzymes in Synthetic Organic Chemistry, (Pergamon Press, New York, 1994), p. 283.Google Scholar
13. The Lectins: Properties. Functions, and Applications in Biology and Medicine, edited by Liener, I.E., Sharon, N., Goldstein, I. (Academic Press, Orlando, 1986).Google Scholar
14. Roy, R., Tropper, F.D., Brisson, J.-R., Williams, A.J., Can. J. Chem. 71, 1995, (1993).Google Scholar