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A microfluidic device with integrated impedance detection for λ-DNA

Published online by Cambridge University Press:  15 February 2011

Myung-Il Park ,
Jonging Hong ,
Dae Sung Yoon ,
Chong-Ook Park  and
Geunbae Im
Myung-Il Park
Affiliation:
Solid State Devices Laboratory, Department of Material Science and Engineering, Korea Advanced Institute of Science and Technology, 373-1 Kusong-dong, Yusong-goo, Daejeon, Republic of Korea
Jonging Hong
Affiliation:
Electronic and Optical Material Laboratory, Department of Material Science and Engineering, Korea Advanced Institute of Science and Technology, 373-1 Kusong-dong, Yusong-goo, Daejeon, Republic of Korea
Dae Sung Yoon
Affiliation:
Biochip Project Team and MEMS Laboratory, Samsung Advanced Institute of Technology, Suwon, Republic of Korea
Chong-Ook Park
Affiliation:
Solid State Devices Laboratory, Department of Material Science and Engineering, Korea Advanced Institute of Science and Technology, 373-1 Kusong-dong, Yusong-goo, Daejeon, Republic of Korea
Geunbae Im
Affiliation:
Biochip Project Team and MEMS Laboratory, Samsung Advanced Institute of Technology, Suwon, Republic of Korea
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Abstract

The large optical detection systems that are typically utilized at present may not be able to reach their full potential as portable analysis tools. Accurate, early, and fast diagnosis for many diseases requires the direct detection of biomolecules such as DNA, proteins, and cells. In this research, a glass microchip with integrated microelectrodes has been fabricated, and the performance of electrochemical impedance detection was investigated for the biomolecules. We have used label-free λ-DNA as a sample biomolecule. By changing the distance between microelectrodes, the significant difference between DW and the TE buffer solution is obtained from the impedance-frequency measurements. In addition, the comparison for the impedance magnitude of DW, the TE buffer, and λ-DNA at the same distance was analyzed.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 773: Symposium N – Biomicroelectromechanical Systems (BioMEMS) , 2003 , N6.5
Copyright
Copyright © Materials Research Society 2003

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