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Optical Properties of Carbon Nanotubes: Near-Infrared Induced Hyperthermia as Therapy for Brain Tumors

Published online by Cambridge University Press:  01 February 2011

Lewis Gomez-De Arco ,
Meng-Tse Chen ,
Weijun Wang ,
Thomas Vernier ,
Paul Pagnini ,
Thomas Chen ,
Martin Gundersen  and
Chongwu Zhou
Lewis Gomez-De Arco
Affiliation:
gomezdea@usc.edu, University of Southern California, Chemistry, 3710 Mc Clintock Ave RTH B118, Los Angeles, CA, 90089, United States
Meng-Tse Chen
Affiliation:
gomezdea@usc.edu, University of Southern California, Chemistry, 3710 Mc Clintock Ave RTH B118, Los Angeles, CA, 90089, United States
Weijun Wang
Affiliation:
gomezdea@usc.edu, University of Southern California, Chemistry, 3710 Mc Clintock Ave RTH B118, Los Angeles, CA, 90089, United States
Thomas Vernier
Affiliation:
gomezdea@usc.edu, University of Southern California, Chemistry, 3710 Mc Clintock Ave RTH B118, Los Angeles, CA, 90089, United States
Paul Pagnini
Affiliation:
gomezdea@usc.edu, University of Southern California, Chemistry, 3710 Mc Clintock Ave RTH B118, Los Angeles, CA, 90089, United States
Thomas Chen
Affiliation:
gomezdea@usc.edu, University of Southern California, Chemistry, 3710 Mc Clintock Ave RTH B118, Los Angeles, CA, 90089, United States
Martin Gundersen
Affiliation:
gomezdea@usc.edu, University of Southern California, Chemistry, 3710 Mc Clintock Ave RTH B118, Los Angeles, CA, 90089, United States
Chongwu Zhou
Affiliation:
gomezdea@usc.edu, University of Southern California, Chemistry, 3710 Mc Clintock Ave RTH B118, Los Angeles, CA, 90089, United States
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Abstract

In this work chemical functionalization of carbon nanotubes was conducted with the aim of improving their ability to be integrated into biological systems. Functionalized SWNT demonstrated to be an excellent vehicle to translocate a highly conjugated organic fluorophore across the cell membrane while causing little toxicity to the cells. Functionalized SWNT were introduced into different lines of the primary brain tumor cells Glioblastoma Multiforme (GBM). Once within the cell interior, the optical properties of the SWNT were used for both fluorescent imaging characterization and selective killing of tumor cells that had exhibited high SWNT uptake levels upon exposure to NIR radiation. Propidium iodide (PI) was employed as an indicator to determine the number of cells with compromised plasma membrane. Cell surviving ratio of as little as 10-20 percent were found in samples with intracellular nanotubes exposed to NIR radiation while a cell surviving ratio of about 95 percent was typical in irradiated samples without intracellular nanotubes. Control samples showed cell surviving ratios comparable to exposed samples without intracellular nanotubes. This study reveals new insights upon the influence of SWNT optical properties in the physicochemical processes within cells and how they can be used to develope therapy for cancerous brain tumors.

Keywords

nanostructurenanoscalebiomaterial
Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 1065: Symposium QQ – Electroactive and Conductive Polymers and Carbon Nanotubes for Biomedical Applications , 2007 , 1065-QQ04-07
Copyright
Copyright © Materials Research Society 2008

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References

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