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Preparation and Charaterization of DAM-1 type Materials

Published online by Cambridge University Press:  15 March 2011

Decio Coutinho ,
Ying Ma  and
Kenneth J. Balkus Jr.
Decio Coutinho
Affiliation:
The University of Texas at Dallas, Department of Chemistry, Richardson, TX 75083-0688
Ying Ma
Affiliation:
The University of Texas at Dallas, Department of Chemistry, Richardson, TX 75083-0688
Kenneth J. Balkus Jr.
Affiliation:
The University of Texas at Dallas, Department of Chemistry, Richardson, TX 75083-0688
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Abstract

Vitamin E TPGS was found to be an effective structure-directing agent for the preparation of both hexagonal all silica DAM-1 and the alumina analog, Al-DAM-1. These free flowing powders offer many advantages in the handling and oral delivery of the sticky vitamin E TPGS. Upon exposure to simulated gastric fluid, the Al-DAM-1 host molecular sieve is dissolved releasing the vitamin E TPGS. As much as 0.6 grams of vitamin E TPGS can be immobilized into 1 gram of Al-DAM-1. Vitamin E TPGS also templates highly ordered mesoporous DAM-1 with tunable morphologies such as hexagons (various lengths), gyroids, rods, spheres and discoids depending upon the temperature and gel composition. Characterization of these composites as well as a preliminary evaluation of Al-DAM-1 as an oral drug delivery system under physiological conditions is presented.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 662: Symposia LL/MM/NN/OO – Biomaterials for Drug Delivery & Tissue Engineering , 2000 , NN6.5
Copyright
Copyright © Materials Research Society 2001

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