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Surface Modification of Superparamagnetic Nanoparticles for in-vivo Bio-medical Applications

Published online by Cambridge University Press:  17 March 2011

D. K. Kim ,
M. Toprak ,
M. Mikhailova ,
Y. Zhang ,
B. Bjelke ,
J. Kehr  and
M. Muhammed
D. K. Kim
Affiliation:
Materials Chemistry Division, Royal Institute of Technology, SE-100 44 Stockholm, Sweden
M. Toprak
Affiliation:
Materials Chemistry Division, Royal Institute of Technology, SE-100 44 Stockholm, Sweden
M. Mikhailova
Affiliation:
Materials Chemistry Division, Royal Institute of Technology, SE-100 44 Stockholm, Sweden
Y. Zhang
Affiliation:
Materials Chemistry Division, Royal Institute of Technology, SE-100 44 Stockholm, Sweden
B. Bjelke
Affiliation:
MRI-Center, Experimental Unit, Karolinska Institutet, SE-171 76 Stockholm, Sweden
J. Kehr
Affiliation:
Division of Cellular and Molecular Neurochemistry, Karolinska Institutet, SE-171 77 Stockholm, Sweden
M. Muhammed
Affiliation:
Materials Chemistry Division, Royal Institute of Technology, SE-100 44 Stockholm, Sweden
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Abstract

Chemical modifications of Superparamagnetic Iron Oxide Nanoparticles (SPION) surfaces by attachment of functional groups and further covalent coupling with biodegradable substances have been studied. Based on computer-assisted chemical equilibrium calculations, several optimum operation conditions for a coprecipitation process of magnetite nanoparticles were predicted. These particles were immobilized by ultra-thin films of PVA, Dextran, Dextrin, PEG and MPEG to obtain a biocompatible particle surface for further functionalization purposes. The effect of surface modification of the superparamagnetic nanoparticles in terms of chemical and physical properties of the samples was investigated with several techniques, including microelectrophoresis measurement. The feasibility of using SPION in biomedical applications was investigated by in-vivo treatment in rat brains.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 704: Symposium W – Nanoparticulate Materials , 2001 , W11.2.1
Copyright
Copyright © Materials Research Society 2002

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