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Using Antibiotic Conjugated Magnetic Nanoparticles and a Magnetic Field for the Treatment of Bone Prosthetic Infections

Published online by Cambridge University Press:  14 March 2011

Erik N. Taylor ,
George E. Aninwene II  and
Thomas J. Webster
Erik N. Taylor
Affiliation:
School of Engineering and Department of Orthopedics, Brown University Providence, RI02906, U.S.A.
George E. Aninwene II
Affiliation:
School of Engineering and Department of Orthopedics, Brown University Providence, RI02906, U.S.A.
Thomas J. Webster
Affiliation:
School of Engineering and Department of Orthopedics, Brown University Providence, RI02906, U.S.A.
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Abstract

Bacterial infection of bone (called osteomyelitis) is of great concern to the medical community. In addition to bone, numerous medical devices are susceptible to microbial colonization when implanted. These infections are chronic since bacteria form a robust adhesion to surfaces, can be protected by sticky slime matrix (called a biofilm) from the body’s immune system (which would otherwise naturally clear the bacteria), and antibiotic treatments may not resolve such infections (due to antibiotic resistance). Here, the multifunctional properties of magnetic nanoparticles (termed here superparamagnetic iron oxide nanoparticles, or SPION) will be explored for their antibacterial activity, magnetic properties, and drug deliverable properties. This study provides a first step towards the development of a new type of pharmaceutical useful for orthopedic or other device related infections by demonstrating physical (magnetic) control of antibiotics towards bacteria and biofilms.

Keywords

biomedicalmagneticnanostructure
Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 1316: Symposium QQ – Nanofunctional Materials, Nanostructures and Nanodevices for Biomedical Applications II , 2011 , mrsf10-1316-qq09-08
Copyright
Copyright © Materials Research Society 2011

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References

REFERENCES

1. Hall-Stoodley, L., Costerton, J.W., and Stoodley, P., Bacterial biofilms: from the Natural environment to infectious diseases . Nat Rev Micro, 2004. 2(2): p. 95–108.Google Scholar
2. Kurtz, S.M., et al. ., Infection burden for hip and knee arthroplasty in the United States . Journal of Arthroplasty, 2008. 23(7): p. 984–991.Google Scholar
3. Bozic, K.J., et al. ., The Epidemiology of Revision Total Hip Arthroplasty in the United States . J Bone Joint Surg Am, 2009. 91(1): p. 128–133.Google Scholar
4. Phillips, J.E., et al. ., The incidence of deep prosthetic infections in specialist orthopaedic hospital - A 15-year prospective survey . Journal of Bone and Joint Surgery-British Volume, 2006. 88B(7): p. 943–948.Google Scholar
5. Sharma, D., et al. ., Microbiology of infected arthroplasty: implications for empiric peri-operative antibiotics . J Orthop Surg (Hong Kong), 2008.16(3): p. 339–42.Google Scholar
6. Hamilton, H. and Jamieson, J., Deep infection in total hip arthroplasty . Canadian Journal of Surgery, 2008. 51(2): p. 111–117.Google Scholar
7. Acosta, F.L., et al. ., Diagnosis and management of adult pyogenic osteomyelitis of the cervical spine . Neurosurgical FOCUS, 2004.17(6): p. 1–9.Google Scholar
8. Klein, E., Smith, D.L., and Laxminarayan, R., Hospitalizations and deaths caused by methicillin-resistantStaphylococcus aureus, United States, 1999-2005 . Emerging Infectious Diseases, 2007.13(12): p. 1840–1846.Google Scholar
9. Otto, M., Staphylococcus epidermidis - the ’accidental’pathogen . Nature sReviews Microbiology, 2009. 7(8): p. 555–567.Google Scholar