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The effect of high-fat diets on gastric inhibitory polypeptide (gip) and insulin secretion in growing pigs

Published online by Cambridge University Press:  24 November 2017

A.A. Ponter ,
D.N. Salter ,
L.M. Morgan  and
P.R. Flatt
A.A. Ponter
Affiliation:
AFRC Institute for Grassland and Animal Production, Church Lane, Shinfield, Reading, Berks. RG2 9AQ
D.N. Salter
Affiliation:
AFRC Institute for Grassland and Animal Production, Church Lane, Shinfield, Reading, Berks. RG2 9AQ
L.M. Morgan
Affiliation:
Department of Biochemistry, University of Surrey, Guildford, Surrey GU2 5XH
P.R. Flatt
Affiliation:
Department of Biochemistry, University of Surrey, Guildford, Surrey GU2 5XH
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Extract

Hyperinsulinaemia, which is associated with obesity and type II diabetes (Gama and Marks, 1989), may be due in part to an overactive enteroinsular axis. The gut hormone GIP is a potent stimulator of insulin secretion and is currently thought to be one of the main components of the enteroinsular axis. Exaggerated GIP responses have been observed after a mixed meal in obese subjects (Hampton, Kwasowski, Tan, Morgan and Marks, 1983), and a high-fat diet increases fat-stimulated GIP secretion in rats (Ebert, Willms, Brown and Creutzfeldt, 1976) and glucose stimulated GIP secretion in man (Morgan, Tredger, Hampton, Kwasowski, Wright, Dunn and Marks, 1983). This experiment was designed to investigate the effects of high-fat diets on the development of the biochemical parameters which are characteristic of obesity.

Type
Pig Production
Information
Proceedings of the British Society of Animal Production (1972) , Volume 1990 , March 1990 , pp. 91
Copyright
Copyright © The British Society of Animal Production 1990

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References

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