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Linkage disequilibrium between single-nucleotide polymorphism in 5`-flanking region and the coding part of bovine beta-Lactoglobulin gene in three native cattle and Holstein breeds of Iran

Published online by Cambridge University Press:  23 November 2017

S. Zakizadeh ,
M. Reissmann  and
P. Reinicke
S. Zakizadeh*
Affiliation:
Hasheminejad High Education Center, Mashhad, Khorasan, Islamic Republic of Iran
M. Reissmann
Affiliation:
Hasheminejad High Education Center, Mashhad, Khorasan, Islamic Republic of Iran
P. Reinicke
Affiliation:
Hasheminejad High Education Center, Mashhad, Khorasan, Islamic Republic of Iran
*
Email:sonia_zaki@yahoo.com
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Extract

Beta-lactoglobulin (LGB) is the best studies protein and found in whey protein milk of ruminants. It has been observed that the heterozygous cows produce LGB-A much more then LGB-B (Wagnet et al. 1994, Gustafson et al. 2003). The differential expression of LGB-A and LGB-B has been suggested to be because of polymorphisms in the regulatory region of LGB, and where these promoter alleles occur in linkage distinct with the alleles in the coding part of the gene (Gustafson et al. 2003). In this study pyrosequencing and PCR-RFLP were utilized to estimate allele frequencies at positions -435(R10), -424(R9), -422(R8) and coding region at codon 64, and also linkage disequilibrium in three native breeds (Mazandarani, Sarabi and Golpaygani) and Holstein cattle of Iran.

Type
Theatre Presentations
Information
Proceedings of the British Society of Animal Science , Volume 2008 , 2008 , pp. 73
Copyright
Copyright © The British Society of Animal Science 2008

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References

Gustafsson, V. and Lunden, A.. 2003. J. Anim. Breed. Genet. 120: 68–72 Google Scholar
Wagner, V. A., Schild, T. A., and Geldermann, H.. 1994. Theor. Appl. Genet. 89:121–126 Google Scholar
Zakizadeh, S., Reissmann, M., Reinecke, P., Rahimi, G., Nejati-Javaremi, A., Miraie-Ashtiani, S.R. 2007. Proceedings of BSAS. p 7 Google Scholar