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Effects of intravenous yohimbine (0.3 mg/kg) on blood pressure and subjective ratings in healthy volunteers

Published online by Cambridge University Press:  28 April 2020

P. Danjou ,
L. Lacomblez ,
D. Warot  and
A.J. Puech
P. Danjou
Affiliation:
Service de Pharmacologie Clinique, Division Ambroise Paré, Hôpital de la Salpêtrière, 47, bd de l’Hôpital, 75651Paris Cedex 13, France
L. Lacomblez
Affiliation:
Service de Pharmacologie Clinique, Division Ambroise Paré, Hôpital de la Salpêtrière, 47, bd de l’Hôpital, 75651Paris Cedex 13, France
D. Warot
Affiliation:
Service de Pharmacologie Clinique, Division Ambroise Paré, Hôpital de la Salpêtrière, 47, bd de l’Hôpital, 75651Paris Cedex 13, France
A.J. Puech
Affiliation:
Service de Pharmacologie Clinique, Division Ambroise Paré, Hôpital de la Salpêtrière, 47, bd de l’Hôpital, 75651Paris Cedex 13, France
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Summary

In a double-blind cross-over study realized in 8 healthy volunteers, a bolus injection of yohimbine (0.15 mg/kg) followed by an infusion (0.0025 mg/kg/min) induced a raise of blood pressure without affecting selfratings. Total dose was 0.3 mg/kg. One subject out of 8 experienced a severe anxiety episode under yohimbine and dropped out.

Résumé

Résumé

Dans un essai croisé en double aveugle réalisé sur 8 volontaires sains, l‘injection d’un bolus de 0,15 mg/kg de yohimbine suivi d’une perfusion (0,0025 mg/kg/min) a entraîné une élévation tensionnelle sans modifier l’autoévaluation. La dose totale injectée était de 0,3 mg/kg. Un sujet sur 8 a présenté un épisode aigu d ‘anxiété sous yohimbine et est sorti d’essai.

Keywords

yohimbineblood pressurepanic attackanxietyhealthy volunteersyohimbinepression artérielleattaque de paniqueanxiétévolontaires sains
Type
Short communication
Information
Psychiatry and Psychobiology , Volume 3 , Issue 1 , 1988 , pp. 57 - 60
Copyright
Copyright © European Psychiatric Association 1988

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