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Aberrant interhemispheric alpha coherence on electroencephalography in schizophrenic patients during activation tasks

Published online by Cambridge University Press:  09 July 2009

S. L. Morrison-Stewart ,
D. Velikonja ,
W. C. Corning  and
P. Williamson
S. L. Morrison-Stewart*
Affiliation:
Department of Research, London Psychiatric Hospital, Ontario, Canada
D. Velikonja
Affiliation:
Department of Research, London Psychiatric Hospital, Ontario, Canada
W. C. Corning
Affiliation:
Department of Research, London Psychiatric Hospital, Ontario, Canada
P. Williamson
Affiliation:
Department of Research, London Psychiatric Hospital, Ontario, Canada
*
1Address for correspondence: Dr Sandra Morrison-Stewart, Department of Psychology, North Bay Psychiatric Hospital, Box 3010, North Bay, Ontario, Canada P1B 8L1.
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Synopsis

Thirty schizophrenic patients (20 medicated, 10 off medication) were compared with 30 normal controls subjects matched for age, sex, handedness and intelligence. During the performance of a frontal activation task, normal subjects showed increased interhemispheric coherence between anterior brain regions. Schizophrenic patients did not show the same amount of bilateral anterior activation. During the performance of right hemisphere cognitive activation tasks, normal subjects and medicated schizophrenic patients showed significantly reduced bilateral interhemispheric coherence patterns, while the drug-free schizophrenic patients showed a trend towards this same pattern. It is suggested that these findings provide additional evidence for an aberrant functional organization of the brain in schizophrenia.

Type
Original Articles
Information
Psychological Medicine , Volume 26 , Issue 3 , May 1996 , pp. 605 - 612
Copyright
Copyright © Cambridge University Press 1996

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