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Erythrocyte membrane cation carrier in manic-depressive psychosis

Published online by Cambridge University Press:  09 July 2009

G. J. Naylor ,
A. H. W. Smith ,
E. G. Dick ,
D. A. T. Dick ,
A. M. McHarg  and
C. A. Chambers
G. J. Naylor*
Affiliation:
Departments of Psychiatry and Anatomy, University of Dundee
A. H. W. Smith
Affiliation:
Departments of Psychiatry and Anatomy, University of Dundee
E. G. Dick
Affiliation:
Departments of Psychiatry and Anatomy, University of Dundee
D. A. T. Dick
Affiliation:
Departments of Psychiatry and Anatomy, University of Dundee
A. M. McHarg
Affiliation:
Departments of Psychiatry and Anatomy, University of Dundee
C. A. Chambers
Affiliation:
Departments of Psychiatry and Anatomy, University of Dundee
*
1Address for correspondence: Dr G. J. Naylor, University Department of Psychiatry, Ninewells Hospital and Medical School, Dundee DDI 9SY.
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Synopsis

Erythrocyte Na–K ATPase and sodium pump site numbers were estimated in groups of depressed, manic and recovered patients. The activity of Na–K ATPase per pump site was lower in the depressed group than in the recovered group. In the manic group Na–K ATPase was lower than that of the recovered group, whereas there was no difference in the pump site numbers. In the more severe manics the activity of Na–K ATPase per pump site was significantly lower than that of the recovered patients. Therefore, the change occurring in the erythrocyte membrane cation carrier in manic-depressive psychosis is probably in the activity of individual Na–K ATPase molecules and not in the number of Na–K ATPase molecules per cell.

Type
Research Article
Information
Psychological Medicine , Volume 10 , Issue 3 , August 1980 , pp. 521 - 525
Copyright
Copyright © Cambridge University Press 1980

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