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Response to drugs in schizophrenia: the influence of family history, obstetric complications and ventricular enlargement

Published online by Cambridge University Press:  09 July 2009

V. L. Nimgaonkar ,
S. Wessely ,
L. E. Tune  and
R. M. Murray
V. L. Nimgaonkar*
Affiliation:
Institute of Psychiatry, LondonPhipps Clinic, Johns Hopkins Medical School, Baltimore, USA
S. Wessely
Affiliation:
Institute of Psychiatry, LondonPhipps Clinic, Johns Hopkins Medical School, Baltimore, USA
L. E. Tune
Affiliation:
Institute of Psychiatry, LondonPhipps Clinic, Johns Hopkins Medical School, Baltimore, USA
R. M. Murray
Affiliation:
Institute of Psychiatry, LondonPhipps Clinic, Johns Hopkins Medical School, Baltimore, USA
*
1Address for correspondence: Dr V. L. Nimgaonkar, Western Psychiatric Institute and Clinic, 3811 O'Hara Street, Pittsburgh, USA 15217.
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Synopsis

A prospective study of antipsychotic drug treatment showed no difference in response between schizophrenic in-patients with or without a familial predisposition to the illness (N = 53). All patients received at least 600 mg chlorpromazine equivalents antipsychotic medication for 6 weeks. Ventricle brain ratios, ratings of cortical sulcal widening and a history of obstetric complications also failed to account for the variability, but early age of onset was associated with unsatisfactory response.

Type
Research Article
Information
Psychological Medicine , Volume 18 , Issue 3 , August 1988 , pp. 583 - 592
Copyright
Copyright © Cambridge University Press 1988

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