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Acute effects of diphenylhydantoin in relation to plasma levels1: Behavioural and psychophysiological studies

Published online by Cambridge University Press:  09 July 2009

C.-M. Ideström ,
D. Schalling ,
U. Carlquist  and
F. Sjöqvist
C.-M. Ideström
Affiliation:
Departments of Experimental Psychiatry, Forensic Psychiatry, and Pharmacology (Division of Clinical Pharmacology), Karolinska Institute, Stockholm, Sweden
D. Schalling
Affiliation:
Departments of Experimental Psychiatry, Forensic Psychiatry, and Pharmacology (Division of Clinical Pharmacology), Karolinska Institute, Stockholm, Sweden
U. Carlquist
Affiliation:
Departments of Experimental Psychiatry, Forensic Psychiatry, and Pharmacology (Division of Clinical Pharmacology), Karolinska Institute, Stockholm, Sweden
F. Sjöqvist
Affiliation:
Departments of Experimental Psychiatry, Forensic Psychiatry, and Pharmacology (Division of Clinical Pharmacology), Karolinska Institute, Stockholm, Sweden
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Synopsis

Two double-blind experiments are reported in which different doses of diphenylhydantoin were compared with placebo. Drug effects on tests, psychophysiological measures, and self-ratings of mood were studied in normal subjects and related to plasma levels of the drug and psychasthenic personality traits. Significant sedative effects were obtained in some self-rating variables. The combined effect in the objective psychological tests was significantly correlated (rank) to the plasma level in the higher dose experiment.

Type
Research Article
Information
Psychological Medicine , Volume 2 , Issue 2 , May 1972 , pp. 111 - 120
Copyright
Copyright © Cambridge University Press 1972

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References

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