Skip to main content
×
Home
    • Aa
    • Aa
  • Get access
    Check if you have access via personal or institutional login
  • Cited by 20
  • Cited by
    This article has been cited by the following publications. This list is generated based on data provided by CrossRef.

    Heaton, Timothy J. and Chico, Victoria 2016. Attitudes towards the sharing of genetic information with at-risk relatives: results of a quantitative survey. Human Genetics, Vol. 135, Issue. 1, p. 109.


    Bloss, C. S. Darst, B. F. Topol, E. J. and Schork, N. J. 2011. Direct-to-consumer personalized genomic testing. Human Molecular Genetics, Vol. 20, Issue. R2, p. R132.


    Hoge, Steven K. and Appelbaum, Paul S. 2012. Ethics and neuropsychiatric genetics: a review of major issues. The International Journal of Neuropsychopharmacology, Vol. 15, Issue. 10, p. 1547.


    Kendler, K S 2013. Decision making in the pathway from genes to psychiatric and substance use disorders. Molecular Psychiatry, Vol. 18, Issue. 6, p. 640.


    Almeling, Rene and Gadarian, Shana Kushner 2014. Public opinion on policy issues in genetics and genomics. Genetics in Medicine, Vol. 16, Issue. 6, p. 491.


    Hohmann, Sarah Adamo, Nicoletta Lahey, Benjamin B. Faraone, Stephen V. and Banaschewski, Tobias 2015. Genetics in child and adolescent psychiatry: methodological advances and conceptual issues. European Child & Adolescent Psychiatry, Vol. 24, Issue. 6, p. 619.


    Gschmeidler, Brigitte and Flatscher-Thoeni, Magdalena 2013. Ethical and Professional Challenges of Genetic Counseling – the Case of Austria. Journal of Genetic Counseling, Vol. 22, Issue. 6, p. 741.


    Ngui, Emmanuel M. Warner, Teddy D. and Weiss Roberts, Laura 2015. Ethical Responsibilities and Perceptions of Stakeholders of Genetic Research Involving Racial/Ethnic Minority Participants. AJOB Empirical Bioethics, Vol. 6, Issue. 3, p. 15.


    Mählmann, Laura Röcke, Christina Brand, Angela Hafen, Ernst and Vayena, Effy 2016. Attitudes towards personal genomics among older Swiss adults: An exploratory study. Applied & Translational Genomics, Vol. 8, p. 9.


    Wilde, Alex Meiser, Bettina Mitchell, Philip B. and Schofield, Peter R. 2011. Community attitudes to genetic susceptibility-based mental health interventions for healthy people in a large national sample. Journal of Affective Disorders, Vol. 134, Issue. 1-3, p. 280.


    Goldsmith, Lesley Jackson, Leigh O’Connor, Anita and Skirton, Heather 2013. Direct-to-consumer genomic testing from the perspective of the health professional: a systematic review of the literature. Journal of Community Genetics, Vol. 4, Issue. 2, p. 169.


    Dedert, Eric A. Elbogen, Eric B. Hauser, Michael A. Hertzberg, Jeff S. Wilson, Sarah M. Dennis, Michelle F. Calhoun, Patrick S. Kirby, Angela C. and Beckham, Jean C. 2012. Consumer Perspectives on Genetic Testing for Psychiatric Disorders: The Attitudes of Veterans with Posttraumatic Stress Disorder and Their Families. Genetic Testing and Molecular Biomarkers, Vol. 16, Issue. 9, p. 1122.


    Erickson, Jessica A. Kuzmich, Lili Ormond, Kelly E. Gordon, Erynn Christman, Michael F. Cho, Mildred K. and Levinson, Douglas F. 2014. Genetic Testing of Children for Predisposition to Mood Disorders: Anticipating the Clinical Issues. Journal of Genetic Counseling, Vol. 23, Issue. 4, p. 566.


    Goldsmith, Lesley Jackson, Leigh O'Connor, Anita and Skirton, Heather 2012. Direct-to-consumer genomic testing: systematic review of the literature on user perspectives. European Journal of Human Genetics, Vol. 20, Issue. 8, p. 811.


    Wilde, Alex Mitchell, Philip B. Meiser, Bettina and Schofield, Peter R. 2013. IMPLICATIONS OF THE USE OF GENETIC TESTS IN PSYCHIATRY, WITH A FOCUS ON MAJOR DEPRESSIVE DISORDER: A REVIEW. Depression and Anxiety, Vol. 30, Issue. 3, p. 267.


    Covolo, Loredana Rubinelli, Sara Ceretti, Elisabetta and Gelatti, Umberto 2015. Internet-Based Direct-to-Consumer Genetic Testing: A Systematic Review. Journal of Medical Internet Research, Vol. 17, Issue. 12, p. e279.


    Sweeny, Kate Ghane, Arezou Legg, Angela M. Huynh, Ho Phi and Andrews, Sara E. 2014. Predictors of Genetic Testing Decisions: A Systematic Review and Critique of the Literature. Journal of Genetic Counseling, Vol. 23, Issue. 3, p. 263.


    Wilde, A. Chan, H.-N. Rahman, B. Meiser, B. Mitchell, P.B. Schofield, P.R. and Green, M.J. 2014. A meta-analysis of the risk of major affective disorder in relatives of individuals affected by major depressive disorder or bipolar disorder. Journal of Affective Disorders, Vol. 158, p. 37.


    Quinn, Veronica Meiser, Bettina Wilde, Alex Cousins, Zoe Barlow-Stewart, Kristine Mitchell, Philip B. and Schofield, Peter R. 2014. Preferences Regarding Targeted Education and Risk Assessment in People with a Family History of Major Depressive Disorder. Journal of Genetic Counseling, Vol. 23, Issue. 5, p. 785.


    Kolor, Katherine Duquette, Debra Zlot, Amy Foland, Joan Anderson, Beth Giles, Rebecca Wrathall, Jennifer and Khoury, Muin J. 2012. Public awareness and use of direct-to-consumer personal genomic tests from four state population-based surveys, and implications for clinical and public health practice. Genetics in Medicine, Vol. 14, Issue. 10, p. 860.


    ×

Community interest in predictive genetic testing for susceptibility to major depressive disorder in a large national sample

  • A. Wilde (a1) (a2), B. Meiser (a3), P. B. Mitchell (a1) (a2) (a4), D. Hadzi-Pavlovic (a1) (a2) and P. R. Schofield (a4) (a5) (a6)
  • DOI: http://dx.doi.org/10.1017/S0033291710002394
  • Published online: 15 December 2010
Abstract
Background

Despite international concern about unregulated predictive genetic testing, there are surprisingly few data on both the determinants of community interest in such testing and its psychosocial impact.

Method

A large population-based public survey with community-dwelling adults (n=1046) ascertained through random digit dialling. Attitudes were assessed by structured interviews.

Results

The study found strong interest in predictive genetic testing for a reported susceptibility to depression. Once the benefits and disadvantages of such testing had been considered, there was significantly greater interest in seeking such a test through a doctor (63%) compared to direct-to-consumer (DTC; 40%) (p<0.001). Personal history of mental illness [odds ratio (OR) 2.58, p<0.001], self-estimation of being at higher than average risk for depression (OR 1.92, p<0.001), belief that a genetic component would increase rather than decrease stigma (OR 1.62, p<0.001), and endorsement of benefits of genetic testing (OR 3.47, p<0.001) significantly predicted interest in having such a test.

Conclusions

Despite finding attitudes that genetic links to mental illness would increase rather than decrease stigma, we found strong community acceptance of depression risk genotyping, even though a predisposition to depression may only manifest upon exposure to stressful life events. Our results suggest that there will be a strong demand for predictive genetic testing.

Copyright
Corresponding author
*Address for correspondence: Dr A. Wilde, School of Psychiatry, University of New South Wales, Black Dog Institute Building, Hospital Road, Randwick, NSW, Australia2031. (Email: alex.wilde@unsw.edu.au)
Linked references
Hide All

This list contains references from the content that can be linked to their source. For a full set of references and notes please see the PDF or HTML where available.

JC Austin , G Smith , WG Honer (2006). The genomic era and perceptions of psychotic disorders: genetic risk estimation, associations with reproductive decisions and views about predictive testing. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics 141B, 926928.

LD Cameron , KA Sherman , TM Marteau , PM Brown (2009). Impact of genetic risk information and type of disease on perceived risk, anticipated affect, and expected consequences of genetic tests. Health Psychology 28, 307316.

A Caspi , K Sugden , TE Moffitt , A Taylor , IW Craig , H Harrington , J McClay , J Mill , J Martin , A Braithwaite , R Poulton (2003). Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene. Science 301, 386389.

TC Eley , K Sugden , A Corsico , AM Gregory , P Sham , P McGuffin , R Plomin , IW Craig (2004). Gene-environment interaction analysis of serotonin system markers with adolescent depression. Molecular Psychiatry 9, 908915.

RC Green , JS Roberts , LA Cupples , NR Relkin , PJ Whitehouse , T Brown , SL Eckert , M Butson , AD Sadovnick , KA Quaid , C Chen , R Cook-Deegan , LA Farrer , for the REVEAL Study Group (2009). Disclosure of APOE genotype for risk of Alzheimer's disease. New England Journal of Medicine 361, 245254.

K Hudson , G Javitt , W Burke , P Byres (2007). ASHG statement on direct-to-consumer genetic testing in the United States. American Journal of Human Genetics 81, 635637.

F Illes , C Rietz , M Fuchs , S Ohiraun , K Prell , G Rudinger , W Maier , M Rietschel (2003). Attitudes towards psychiatric genetic research and predictive testing: hopes and fears of patients, relatives and the general population in Germany [in German]. Ethik in der Medizin 15, 268281.

I Jones , J Scourfield , F McCandless , N Craddock (2002). Attitudes towards future testing for bipolar disorder susceptibility genes: a preliminary investigation. Journal of Affective Disorders 71, 189193.

J Kaufman , B-Z Yang , H Douglas-Palumberi , S Houshyar , D Lipschitz , JH Krystal , J Gelernter (2004). Social supports and serotonin transporter gene moderate depression in maltreated children. Proceedings of the National Academy of Sciences USA 101, 1731617321.

KS Kendler , JW Kuhn , J Vittum , CA Prescott , B Riley (2005). The interaction of stressful life events and a serotonin transporter polymorphism in the prediction of episodes of major depression: a replication. Archives of General Psychiatry 62, 529535.

KS Kendler , CA Prescott (1999). A population-based twin study of lifetime major depression in men and women. Archives of General Psychiatry 56, 3944.

P Kraft , DJ Hunter (2009). Genetic risk prediction – are we there yet? New England Journal of Medicine 360, 17011703.

MM Laegsgaard , AS Kristensen , O Mors (2009). Potential consumers' attitudes toward psychiatric genetic research and testing and factors influencing their intentions to test. Genetic Testing and Molecular Biomarkers 13, 5765.

MM Laegsgaard , O Mors (2008). Psychiatric genetic testing: attitudes and intentions among future users and providers. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics 147B, 375384.

C Lerman , R Croyle , K Tercyak , H Hamann (2002). Genetic testing: psychological aspects and implications. Journal of Consulting and Clinical Psychology 70, 784797.

P McGuffin , R Katz , S Watkins , J Rutherford (1996). A hospital-based twin register of the heritability of DSM-IV unipolar depression. Archives of General Psychiatry 53, 129136.

B Meiser , NA Kasparian , PB Mitchell , K Strong , JM Simpson , L Tabassum , S Mireskandari , PR Schofield (2008). Attitudes to genetic testing in families with multiple cases of bipolar disorder. Genetic Testing 12, 233244.


B Meiser , PB Mitchell , H McGirr , M van Herten , PR Schofield (2005). Implications of genetic risk information in families with a high density of bipolar disorder: an exploratory study. Social Science and Medicine 60, 109118.

SI Mishra , D Dooley , R Catalano , S Serxner (1993). Telephone health surveys: potential bias from noncompletion. American Journal of Public Health 83, 9499.

DM Purdie , MP Dunne , FM Boyle , MD Cook , JM Najman (2002). Health and demographic characteristics of respondents in an Australian national sexuality survey: comparison with population norms. Journal of Epidemiology and Community Health 56, 748753.

SC Sanderson , J Wardle , MJ Jarvis , SE Humphries (2004). Public interest in genetic testing for susceptibility to heart disease and cancer: a population-based survey in the UK. Preventive Medicine 39, 458464.

P Shetty (2008). Home DNA test kits cause controversy. Lancet 371, 17391740.

LB Smith , B Sapers , VI Reus , NB Freimer (1996). Attitudes towards bipolar disorder and predictive genetic testing among patients and providers. Journal of Medical Genetics 33, 544549.

A Sogaard , R Selmer , E Bjertness , D Thelle (2004). The Oslo Health Study: the impact of self-selection in a large, population-based survey. International Journal for Equity in Health 3, 3.

SE Taylor , BM Way , WT Welch , CJ Hilmert , BJ Lehman , NI Eisenberger (2006). Early family environment, current adversity, the serotonin transporter promoter polymorphism, and depressive symptomatology. Biological Psychiatry 60, 671676.

CL Trippitelli , KR Jamison , MF Folstein , JJ Bartko , JR Depaulo (1998). Pilot study on patients' and spouses' attitudes toward potential genetic testing for bipolar disorder. American Journal of Psychiatry 155, 899904.

I Van Hoyweghen , K Horstman (2008). European practices of genetic information and insurance: lessons for the Genetic Information Nondiscrimination Act. Journal of the American Medical Association 300, 326327.

A Wilde , B Meiser , PB Mitchell , PR Schofield (2010). Public interest in predictive genetic testing, including direct-to-consumer testing, for susceptibility to major depression: preliminary findings. European Journal of Human Genetics 18, 4751.

K Wilhelm , B Meiser , PB Mitchell , AW Finch , J Siegel , G Parker , PR Schofield (2009). Issues concerning feedback to participants about their serotonin transporter genotype and risks for depression. British Journal of Psychiatry 194, 404410.

K Wilhelm , PB Mitchell , H Niven , A Finch , L Wedgwood , A Scimone , IP Blair , G Parker , PR Schofield (2006). Life events, first depression onset and the serotonin transporter gene. British Journal of Psychiatry 188, 210215.

KD Zonno , SF Terry (2009). Registry of genetic tests: a critical stepping stone to improving the genetic testing system. Genetic Testing and Molecular Biomarkers 13, 153154.

Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

Psychological Medicine
  • ISSN: 0033-2917
  • EISSN: 1469-8978
  • URL: /core/journals/psychological-medicine
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Keywords: