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Genetic and environmental contributions to retrospectively reported DSM-IV childhood attention deficit hyperactivity disorder

  • B. C. Haberstick (a1) (a2), D. Timberlake (a1) (a3), C. J. Hopfer (a2), J. M. Lessem (a1), M. A. Ehringer (a1) and J. K Hewitt (a1)
  • DOI:
  • Published online: 01 September 2007

A variety of methodologies and techniques converge on the notion that adults and children with attention deficit hyperactivity disorder (ADHD) have similar deficits, but there is limited knowledge about whether adult retrospective reports reflect similar genetic and environmental influences implicated in childhood ADHD.


DSM-IV ADHD symptoms were collected retrospectively from 3896 young adults participating in the National Longitudinal Study of Adolescent Health. Responses from this genetically informative sample of same- and opposite-sex twins and siblings were used to determine the magnitude of genetic and environmental influences. Possible gender differences in these effects were also examined. The degree of familial specificity of the genetic and environmental influences on the Inattentive and Hyperactive-Impulsive symptom dimensions was also determined.


Additive genetic effects contributed moderately to DSM-IV Inattentive, Hyperactive-Impulsive and Combined ADHD subtypes (heritability estimates of 0.30–0.38). Individual-specific influences accounted for the remaining proportion of the variance. Both genetic and individual-specific environmental effects contributed to the covariation of Inattentive and Hyperactive-Impulsive symptomologies.


Results from our genetic analyses agree with previous findings based on self-assessment of current and retrospectively reported ADHD symptoms in adolescents and adults. Large individual-specific environmental influences as identified here suggest that current questionnaires used for retrospective diagnoses may not provide the most accurate reconstruction of the etiological influences on childhood ADHD in general population samples.

Corresponding author
*Address for correspondence: Dr B. C. Haberstick, Institute of Behavioral Genetics, University of Colorado, Campus Box 0447, Boulder, CO 80309-0447, USA. (Email:
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H Akaike (1987). Factor analyses and AIC. Psychometrika 52, 317322.

RA Barkley , M Fischer , L Smallish , K Fletcher (2002). The persistence of attention-deficit/hyperactivity disorder into young adulthood as a function of reporting source and definition of disorder. Journal of Abnormal Psychology 111, 279289.

RA Barkley , M Fischer , L Smallish , K Fletcher (2004). Young adult follow-up of hyperactive children: antisocial activities and drug use. Journal of Child Psychology and Psychiatry 45, 195211.

MA Ehringer , SH Rhee , S Young , R Corley , JK Hewitt (2006). Genetic and environmental contributions to common psychopathologies of childhood and adolescence: a study of twins and their siblings. Journal of Abnormal Child Psychology 34, 117.

SV Faraone , J Biederman , JA Feighner , MC Monuteaux (2000). Assessing symptoms of attention deficit hyperactivity disorder in children and adults: which is more valid? Journal of Consulting and Clinical Psychology 68, 830842.

SV Faraone , J Biederman , T Spencer , E Mick , K Murray , C Petty , JJ Adamson , MC Monuteaux (2006). Diagnosing adult attention deficit hyperactivity disorder: are late onset and subthreshold diagnoses valid? American Journal of Psychiatry 163, 17201729.

AS Hervey , JN Epstein , JF Curry (2004). Neuropsychology of adults with attention-deficit/hyperactivity disorder: a meta-analytic review. Neuropsychology 18, 485503.

JJ Hudziak , EM Derks , RR Althoff , DC Rettew , DI Boomsma (2005). The genetic and environmental contributions to attention deficit hyperactivity disorder as measured by the Conners' Rating Scales-Revised. American Journal of Psychiatry 162, 16141620.

KM Linnet , S Dalsgaard , C Obel , K Wisborg , TB Henriksen , A Rodriguez , A Kotimaa , I Moilanen , PH Trhomsen , J Olsen , MR Jarvelin (2003). Maternal lifestyle factor in pregnancy risk of attention deficit hyperactivity disorder and associated behaviors: review of the current evidence. American Journal of Psychiatry 160, 10281040.

P Magnusson , J Smari , D Siguroardottir , G Baldursson , J Sigmundsson , K Kristjansson , S Siguroardottir , S Hreioarsson , S Sigurbjornsdottir , O Guomundsson (2006). Validity of self-report and informant rating scales of adult ADHD symptoms in comparison with semistructured diagnostic interview. Journal of Attention Disorders 9, 494503.

C Mancini , M Van Ameringen , JM Oakman , D Figueiredo (1999). Childhood attention deficit/hyperactivity disorder in adults with anxiety disorders. Psychological Medicine 29, 515525.

N Martin , J Scourfield , P McGuffin (2002). Observed effects and heritability of childhood attention-deficit hyperactivity disorder symptoms. British Journal of Psychiatry 180, 260265.

BS McCann , L Scheele , N Ward , P Roy-Byrne (2000). Discriminant validity of the Wender Utah Ratings Scale for attention-deficit/hyperactivity disorder in adults. Journal of Neuropsychiatry and Clinical Neurosciences 12, 240245.

JJ McGough , RA Barkley (2004). Diagnostic controversies in adult attention deficit hyperactivity disorder. American Journal of Psychiatry 161, 19481956.

P Muglia , U Jain , F Macciardi , JL Kennedy (2000). Adult attention deficit hyperactivity disorder and the dopamine D4 receptor gene. American Journal of Medical Genetics (Neuropsychiatric Genetics) 96, 273277.

K Murphy , RA Barkley (1996). Attention deficit hyperactivity disorder adults: comorbidities and adaptive impairments. Comprehensive Psychiatry 37, 393401.

P Murphy , R Schachar (2000). Use of self-ratings in the assessment of symptoms of attention deficit hyperactivity disorder in adults. American Journal of Psychiatry 157, 11561159.

MC Neale , LR Cardon (1992). Methodology for Genetic Study of Twins and Families. Kluwer Academic Publishers: Dordrecht.

MC Neale , E Roysamb , K Jacobson (2006). Multivariate genetic analysis of sex limitation and G×E interaction. Twin Research and Human Genetics 9, 481489.

W Retz , J Thome , D Blocher , M Baader , M Rosler (2002). Association of attention deficit hyperactivity disorder-related psychopathology and personality traits with the serotonin transporter region polymorphism. Neuroscience Letters 319, 133136.

SH Rhee , ID Waldman , DA Hay , F Levy (1999). Sex differences in genetic and environmental influences on DSM-III-R attention-deficit/hyperactivity disorder. Journal of Abnormal Psychology 108, 2441.

MJ Rietveld , JJ Hudziak , M Bartels , CE van Beijsterveldt , DI Boomsma (2004). Heritability of attention problems in children: longitudinal results from a study of twins, age 3 to 12. Journal of Child Psychology and Psychiatry 45, 577588.

LJ Seidman , J Biederman , W Weber , M Hatch , SV Faraone (1998). Neuropsychological function in adults with attention-deficit hyperactivity disorder. Biological Psychiatry 44, 260268.

T Spencer , J Biderman , T Wilens , R Doyle , C Surman , J Prince , E Mick , M Aleardi , K Herzig , SV Faraone (2005). A large, double-blind, randomized clinical trial of methylphenidate in the treatment of adults with attention-deficit/hyperactivity disorder. Biological Psychiatry 57, 456463.

A Thapar , J Holmes , K Poulton , R Harrington (1999). Genetic basis of attention deficit and hyperactivity. British Journal of Psychiatry 174, 105111.

DC Turner , AD Blackwell , JH Dowson , A McLean , BJ Sahakian (2005). Neurocognitive effects of methyphenidate in adult attention-deficit/hyperactivity disorder. Psychopharmacology 178, 286295.

SM van den Berg , G Willemsen , EJC de Geus , DI Boomsmam (2006). Genetic etiology of stability of attention problems in young adulthood. American Journal of Medical Genetics 141B, 5560.

PH Wender , FW Reimherr , DR Wood (1981). Attention deficit hyperactivity disorder (‘minimal brain dysfunction’) in adults. Archives of General Psychiatry 38, 449456.

PH Wender , LE Wolf , J Wasserstein (2001). Adults with ADHD: an overview. Annals of the New York Academy of Sciences 931, 116.

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