Allgulander, C, Hartford, J, Russell, J, Ball, S, Erickson, J, Raskin, J, Rynn, M (2007). Pharmacotherapy of generalized anxiety disorder: results of duloxetine treatment from a pooled analysis of three clinical trials. Current Medical Research Opinion 23, 1245–1252.
Allgulander, C, Nutt, D, Detke, MJ, Erickson, J, Spann, M, Walker, D, Ball, SG, Russell, JM (in press). A noninferiority comparison of duloxetine and venlafaxine XR in the treatment of adult patients with generalized anxiety disorder. Journal of Psychopharmacology.
APA (1994). DSM-IV: Diagnostic and Statistical Manual of Mental Disorders, 4th edn. American Psychiatric Association: Washington, DC.
Ballenger, JC, Davidson, JR, Lecrubier, Y, Nutt, DJ, Borkovec, TD, Rickels, K, Stein, DJ, Wittchen, HU (2001). Consensus statement on generalized anxiety disorder from the International Consensus Group on Depression and Anxiety. Journal of Clinical Psychiatry 62 (Suppl. 11), 53–58.
Becker, ES, Goodwin, R, Hölting, C, Hoyer, J, Margraf, J (2003). Content of worry in the community: what do people with generalized anxiety disorder or other disorders worry about? Journal of Nervous and Mental Disease 191, 688–691.
Covi, L, Lipman, R, McNair, DM, Czerlinsky, T (1979). Symptomatic volunteers in multicenter drug trials. Progress in Neuropsychopharmacology 3, 521–533.
Culpepper, L (2002). Generalized anxiety disorder in primary care: emerging issues in management and treatment. Journal of Clinical Psychiatry 63 (Suppl. 8), 35–42.
Doyle, AC, Pollack, MH (2003). Establishment of remission criteria for anxiety disorders. Journal of Clinical Psychiatry 64 (Suppl. 15), 40–45.
Guy, W (1976). ECDEU Assessment Manual for Psychopharmacology. National Institute of Mental Health, Psychopharmacology Research Branch, Division of Extramural Research Programs: Rockville, MD.
Hamilton, M (1959). The assessment of anxiety states by rating. British Journal of Medical Psychology 32, 50–55.
Hartford, J, Kornstein, S, Liebowitz, M, Pigott, T, Russell, J, Detke, M, Walker, D, Ball, S, Dunayevich, E, Dinkel, J, Erickson, J (2007). Duloxetine as an SNRI treatment for generalized anxiety disorder: results from a placebo- and active-controlled trial. International Clinical Psychopharmacology 22, 167–174.
Hedges, LV, Olkin, I (1985). Examination of a single effect size: parametric and nonparametric methods. In Statistical Methods for Meta-Analysis, pp. 75–106. Academic Press, Inc: Orlando, FL.
Joubert, AF, du Plessis, AD, Faries, D, Gagiano, CA (1997). High placebo response rate versus clinical impression with the new antidepressant duloxetine. Biological Psychiatry 42, 229S–230S.
Kessler, RC, Berglund, P, Demler, O, Jin, R, Merikangas, KR, Walters, EE (2005). Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication. Archives of General Psychiatry 62, 593–602. Erratum in Archives of General Psychiatry (2005) 62, 768.
Kessler, RC, Wittchen, HU (2002). Patterns and correlates of generalized anxiety disorder in community samples. Journal of Clinical Psychiatry 63 (Suppl. 8), 4–10.
Koponen, H, Allgulander, C, Erickson, J, Dunayevich, E, Pritchett, Y, Detke, MJ, Ball, SG, Russell, JM (2007). Efficacy of duloxetine for the treatment of generalized anxiety disorder: implications for primary care physicians. Primary Care Companion of the Journal of Clinical Psychiatry 9, 100–107.
Lipsitz, J, Kobak, K, Feiger, A, Sikich, D, Moroz, G, Englehardt, N (2004). The Rater Applied Performance Scale: development and reliability. Psychiatry Research 127, 147–155.
Lydiard, RB (2000). An overview of generalized anxiety disorder: disease state-appropriate therapy. Clinical Therapeutics 22, A3–A24.
Meoni, P, Hackett, D, Lader, M (2004). Pooled analysis of venlafaxine XR efficacy on somatic and psychic symptoms of anxiety in patients with generalized anxiety disorder. Depression and Anxiety 19, 127–132.
Olfson, M, Shea, S, Feder, A, Fuentes, M, Nomura, Y, Gameroff, M, Weissman, MM (2000). Prevalence of anxiety, depression, and substance use disorders in an urban general medicine practice. Archives of Family Medicine 9, 876–883.
Papakostas, GI, Thase, ME, Fava, M, Nelson, JC, Shelton, RC (2007). Are antidepressant drugs that combine serotonergic and noradrenergic mechanisms of action more effective than the selective serotonin reuptake inhibitors in treating major depressive disorder? A meta analysis of studies of newer agents. Biological Psychiatry 62, 1217–1227.
Pollack, MH (2001). Optimizing pharmacotherapy of generalized anxiety disorder to achieve remission. Journal of Clinical Psychiatry 62 (Suppl. 19), 20–25.
Rickels, K, Pollack, MH, Sheehan, DV, Haskins, JT (2000). Efficacy of extended-release venlafaxine in nondepressed outpatients with generalized anxiety disorder. American Journal of Psychiatry 157, 968–974.
Ruscio, AM, Borkovec, TD (2004). Experience and appraisal of worry among high worriers with and without generalized anxiety disorder. Behaviour Research and Therapy 42, 1469–1482.
Rynn, M, Russell, J, Erickson, J, Detke, MJ, Ball, S, Dinkel, J, Rickels, K, Raskin, J (2008). Efficacy and safety of duloxetine in the treatment of generalized anxiety disorder: a flexible-dose, progressive-titration, placebo-controlled trial. Depression and Anxiety 25, 182–189.
Shear, MK, Vander Bilt, J, Rucci, P, Endicott, J, Lydiard, B, Otto, MW, Pollack, MH, Chandler, L, Williams, J, Ali, A, Frank, DM (2001). Reliability and validity of a structured interview guide for the Hamilton Anxiety Rating Scale (SIGH-A). Depression and Anxiety 13, 166–178.
Sheehan, DV (1983). The Anxiety Disease. Charles Scriber and Sons: New York, NY.
Sheehan, DV, Lecrubier, Y, Sheehan, KH, Amorim, P, Janavs, J, Weiller, E, Hergueta, T, Baker, R, Dunbar, GC (1998). The Mini International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. Journal of Clinical Psychiatry 59 (Suppl. 20), 22–33.
Stahl, SM, Ahmed, S, Haudiquet, V (2007). Analysis of the rate of improvement of specific psychic and somatic symptoms of general anxiety disorder during long-term treatment with venlafaxine ER. CNS Spectrums 12, 703–711.
Wittchen, HU, Kessler, RC, Beesdo, K, Krause, P, Hofler, M, Hoyer, J (2002). Generalized anxiety and depression in primary care: prevalence, recognition, and management. Journal of Clinical Psychiatry 63 (Suppl. 8), 24–34.
World Medical Association (2000). Declaration of Helsinki: Ethical Principles for Medical Research Involving Human Subjects (www.wma.net/e/policy/b3.htm). Accessed 28 September 2007.
Zigmond, AS, Snaith, RP (1983). The hospital anxiety and depression scale. Acta Psychiatrica Scandinavica 67, 361–370.