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Interaction between a history of depression and rumination on neural response to emotional faces

  • E. J. Thomas (a1), R. Elliott (a1), S. McKie (a1), D. Arnone (a1), D. Downey (a2), G. Juhasz (a1), J. F. W. Deakin (a1) and I. M. Anderson (a1)...
Abstract
Background

Both past depressive episodes and the personality trait of depressive rumination are strong risk factors for future depression. Depression is associated with abnormal emotional processing, which may be a neurobiological marker for vulnerability to depression. A consistent picture has yet to emerge as to how a history of depression and the tendency to ruminate influence emotional processing. The aim of this study was to investigate the relationship between rumination, past depression and neural responses when processing face emotions.

Method

The Ruminative Responses Scale (RRS) was completed by 30 remitted depressives and 37 controls who underwent functional magnetic resonance imaging (fMRI) scanning while viewing happy, sad, fearful and neutral faces.

Results

The remitted depressives showed overall reductions in neural responses to negative emotions relative to the controls. However, in the remitted depressives, but not the controls, RRS scores were correlated with increased neural responses to negative emotions and decreased responses to happiness in limbic regions.

Conclusions

Automatic emotion processing biases and rumination seem to be correlated to aspects of vulnerability to depression. However, remission from depression may be maintained by a general suppression of limbic responsiveness to negative emotion.

Copyright
Corresponding author
*Address for correspondence: Dr E. J. Thomas, Neuroscience and Psychiatry Unit, G.704 Stopford Building, University of Manchester, Oxford Road, Manchester M13 9PT, UK. (Email: emma.j.thomas@manchester.ac.uk)
Linked references
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This list contains references from the content that can be linked to their source. For a full set of references and notes please see the PDF or HTML where available.

CS Monk , RG Klein , EH Telzer , EA Schroth , S Mannuzza , JL Moulton , M Guardino , CL Masten , EB Clure-Tone , S Fromm , RJ Blair , DS Pine , M Ernst (2008). Amygdala and nucleus accumbens activation to emotional facial expressions in children and adolescents at risk for major depression. American Journal of Psychiatry 165, 9098.

SA Montgomery , M Asberg (1979). New depression scale designed to be sensitive to change. British Journal of Psychiatry 134, 382389.

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Psychological Medicine
  • ISSN: 0033-2917
  • EISSN: 1469-8978
  • URL: /core/journals/psychological-medicine
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