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Marital resemblance for obsessive–compulsive, anxious and depressive symptoms in a population-based sample

  • D. S. van Grootheest (a1) (a2), S. M. van den Berg (a1) (a3), D. C. Cath (a2), G. Willemsen (a1) and D. I. Boomsma (a1)...
Abstract
Background

Resemblance between spouses can be due to phenotypic assortment, social homogamy and/or marital interaction. A significant degree of assortment can have consequences for the genetic architecture of a population. We examined the existence and cause(s) of assortment for obsessive–compulsive (OC), anxious and depressive symptoms in a population-based twin-family sample.

Method

OC, anxious and depressive symptoms were measured in around 1400 twin–spouse pairs and >850 parent pairs. Correlations of twins and their spouse, twin and co-twin's spouse, spouses of both twins and parents of twins were obtained to consider phenotypic assortment versus social homogamy as possible causes of marital resemblance. The association of length of relationship with marital resemblance was also investigated. Finally, we examined whether within-trait or cross-trait processes play a primarily role in marital resemblance.

Results

Small but significant within-trait correlations of between 0.1 and 0.2 were seen for spouse similarity in OC, anxious and depressive symptoms. Cross-correlations were significant but lower. There was no correlation between length of relationship and marital resemblance. From the pattern of correlations for twin–spouse, co-twin–spouse and spouses of both twins, phenotypic assortment could not be distinguished from social homogamy. Both within- and cross-assortment processes play a role in marital resemblance.

Conclusions

Small within- and across-trait correlations exist for OC, anxious and depressive symptoms. No evidence for marital interaction was found. Spouse correlations are small, which makes it difficult to distinguish between social homogamy and phenotypic assortment. It is unlikely that correlations of this size will have a large impact on genetic studies.

Copyright
Corresponding author
*Address for correspondence: D. S. van Grootheest, M.D., Vrije Universiteit Amsterdam, Department of Biological Psychology, Van der Boechorststraat 1, 1081 BT Amsterdam, The Netherlands. (Email: Ds.van.grootheest@psy.vu.nl)
References
Hide All
Achenbach TM (1997). Manual for the Young Adult Self-Report and Young Adult Behavior Checklist. University of Vermont, Department of Psychiatry: Burlington, VT.
Boomsma DI, de Geus EJ, Vink JM, Stubbe JH, Distel MA, Hottenga JJ, Posthuma D, van Beijsterveldt CE, Hudziak JJ, Bartels M, Willemsen G (2006). Netherlands Twin Register: from twins to twin families. Twin Research and Human Genetics 9, 849857.
Boomsma DI, Vink JM, van Beijsterveldt TC, de Geus EJ, Beem AL, Mulder EJ, Derks EM, Riese H, Willemsen GA, Bartels M, van den Berg M, Kupper NH, Polderman TJ, Posthuma D, Rietveld MJ, Stubbe JH, Knol LI, Stroet T, van Baal GC (2002). Netherlands Twin Register: a focus on longitudinal research. Twin Research 5, 401406.
Carey G (1986). A general multivariate approach to linear modeling in human genetics. American Journal of Human Genetics 39, 775786.
Cath DC, van Grootheest DS, Willemsen G, Van Oppen P, Boomsma DI (2008). Environmental influences on obsessive-compulsive behavior: evidence from discordant and concordant monozygotic twins. Behavior Genetics. Published online: 11 January 2008. doi: 10.1007/s10519-007-9185-9.
Clifford CA, Murray RM, Fulker DW (1984). Genetic and environmental influences on obsessional traits and symptoms. Psychological Medicine 14, 791800.
Crow JF, Felsenstein J (1968). The effect of assortative mating on the genetic composition of a population. Eugenics Quarterly 15, 8597.
Derks EM, Dolan CV, Boomsma DI (2004). Effects of censoring on parameter estimates and power in genetic modeling. Twin Research 7, 659669.
Dubuis-Stadelmann E, Fenton BT, Ferrero F, Preisig M (2001). Spouse similarity for temperament, personality and psychiatric symptomatology. Personality and Individual Differences 30, 10951112.
Eagles JM, Walker LG, Blackwood GW, Beattie JA, Restall DB (1987). The mental health of elderly couples. II. Concordance for psychiatric morbidity in spouses. British Journal of Psychiatry 150, 303308.
Falconer DS, Mackay TFC (1996). Introduction to Quantitative Genetics, 4th edn.Longman Group Ltd.: Essex.
Ferdinand RF, Verhulst FC, Wiznitzer M (1995). Continuity and change of self-reported problem behaviors from adolescence into young adulthood. Journal of the American Academy of Child and Adolescent Psychiatry 34, 680690.
Fisher RA (1918). The correlation between relatives on the supposition of Medelian inheritance. Transactions of the Royal Society 52, 399433.
Galbaud du Fort G, Bland RC, Newman SC, Boothroyd LJ (1998). Spouse similarity for lifetime psychiatric history in the general population. Psychological Medicine 28, 789802.
Heath AC, Eaves LJ (1985). Resolving the effects of phenotype and social background on mate selection. Behavior Genetics 15, 1530.
Hettema JM, Neale MC, Kendler KS (2001). A review and meta-analysis of the genetic epidemiology of anxiety disorders. American Journal of Psychiatry 158, 15681578.
Jonnal AH, Gardner CO, Prescott CA, Kendler KS (2000). Obsessive and compulsive symptoms in a general population sample of female twins. American Journal of Medical Genetics 96, 791796.
Low N, Cui L, Merikangas KR (2007). Spousal concordance for substance use and anxiety disorders. Journal of Psychiatric Research 41, 942951.
Maes HH, Neale MC, Kendler KS, Hewitt JK, Silberg JL, Foley DL, Meyer JM, Rutter M, Simonoff E, Pickles A, Eaves LJ (1998). Assortative mating for major psychiatric diagnoses in two population-based samples. Psychological Medicine 28, 13891401.
Martin NG (1978). Genetics of social and sexual attitudes. In Twin Research: Psychology and Methodology (ed. Nance W. E.), pp. 1323. Alan R. Liss: New York.
Mathews CA, Nievergelt CM, Azzam A, Garrido H, Chavira DA, Wessel J, Bagnarello M, Reus VI, Schork NJ (2007). Heritability and clinical features of multigenerational families with obsessive-compulsive disorder and hoarding. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics 144, 174182.
Mathews CA, Reus VI (2001). Assortative mating in the affective disorders: a systematic review and meta-analysis. Comprehensive Psychiatry 42, 257262.
McLeod JD (1995). Social and psychological bases of homogamy for common psychiatric disorders. Journal of Marriage and the Family 57, 201204.
Merikangas KR (1982). Assortative mating for psychiatric disorders and psychological traits. Archives of General Psychiatry 39, 11731180.
Merikangas KR (1984). Divorce and assortative mating among depressed patients. American Journal of Psychiatry 141, 7476.
Middeldorp CM, Cath DC, van den Berg M, Beem AL, Van Dyck R, Boomsma DI (2006). The association of personality with anxious and depressive psychopathology. In The Biological Basis of Personality and Individual Differences (ed. Canli T.), pp. 251272. Guilford Press: New York.
Neale MC, Boker SM, Xie G, Maes HM (2003). Mx: Statistical Modeling, 6th edn.Department of Psychiatry, VCU Box 900126: Richmond, VA.
Neale MC, Cardon LR (1992). Methodology for Genetic Studies of Twins and Families. Kluwer Academic: Dordrecht, The Netherlands.
Penrose LS (1944). Mental illness in husband and wife: a contribution to the study of assortative mating in man. Psychiatric Quarterly Supplement 18, 161166.
Phillips K, Fulker DW, Carey G, Nagoshi CT (1988). Direct marital assortment for cognitive and personality variables. Behavior Genetics 18, 347356.
Reynolds CA, Baker LA, Pedersen NL (2000). Multivariate models of mixed assortment: phenotypic assortment and social homogamy for education and fluid ability. Behavior Genetics 30, 455476.
Reynolds CA, Barlow T, Pedersen NL (2006). Alcohol, tobacco and caffeine use: spouse similarity processes. Behavior Genetics 32, 201215.
Sanavio E (1988). Obsessions and compulsions: the Padua Inventory. Behavior Research and Therapy 26, 169177.
Spielberger CD (1983). Manual for the State-Trait Anxiety Inventory STAI (Form Y). Consulting Psychologists Press: Palo Alto, CA.
Sullivan PF, Neale MC, Kendler KS (2000). Genetic epidemiology of major depression: review and meta-analysis. American Journal of Psychiatry 157, 15521562.
Tambs K (1991). Transmission of symptoms of anxiety and depression in nuclear families. Journal of Affective Disorders 21, 117126.
van der Ploeg HM (2000). Guide to the Dutch version of the Spielberger State-trait Anxiety Inventory, STAI-DY. Swets en Zeitlinger bv: Lisse.
van Grootheest DS, Bartels M, Cath DC, Beekman AT, Hudziak JJ, Boomsma DI (2007). Genetic and environmental contributions underlying stability in childhood obsessive-compulsive behavior. Biological Psychiatry 61, 308315.
van Grootheest DS, Cath DC, Beekman AT, Boomsma DI (2005). Twin studies on obsessive-compulsive disorder: a review. Twin Research and Human Genetics 8, 450458.
Van Oppen P, Hoekstra RJ, Emmelkamp PM (1995). The structure of obsessive-compulsive symptoms. Behavior Research and Therapy 33, 1523.
Wade TJ, Cairney J (2000). Major depressive disorder and marital transition among mothers: results from a national panel study. Journal of Nervous and Mental Disease 188, 741750.
Wiznitzer M, Verhulst FC, van den Brink W, Koeter M, van der Ende J, Giel R, Koot HM (1992). Detecting psychopathology in young adults: the Young Adult Self Report, the General Health Questionnaire and the Symptom Checklist as screening instruments. Acta Psychiatrica Scandinavica 86, 3237.
Wright S (1921). Assortative mating based on somatic resemblance. Genetics 6, 144161.
Zimmermann-Tansella C, Lattanzi M (1991). The Ryle Marital Patterns Test as a predictor of symptoms of anxiety and depression in couples in the community. Social Psychiatry and Psychiatric Epidemiology 26, 221229.
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Psychological Medicine
  • ISSN: 0033-2917
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