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Neural correlates of ‘pessimistic’ attitude in depression

  • U. Herwig (a1) (a2), A. B. Brühl (a1), T. Kaffenberger (a1) (a2), T. Baumgartner (a3) (a4), H. Boeker (a1) and L. Jäncke (a3)...
Abstract
Background

Preparing for potentially threatening events in the future is essential for survival. Anticipating the future to be unpleasant is also a cognitive key feature of depression. We hypothesized that ‘pessimism’-related emotion processing would characterize brain activity in major depression.

Method

During functional magnetic resonance imaging, depressed patients and a healthy control group were cued to expect and then perceive pictures of known emotional valences – pleasant, unpleasant and neutral – and stimuli of unknown valence that could have been either pleasant or unpleasant. Brain activation associated with the ‘unknown’ expectation was compared with the ‘known’ expectation conditions.

Results

While anticipating pictures of unknown valence, activation patterns in depressed patients within the medial and dorsolateral prefrontal areas, inferior frontal gyrus, insula and medial thalamus were similar to activations associated with expecting unpleasant pictures, but not with expecting positive pictures. The activity within a majority of these areas correlated with the depression scores. Differences between healthy and depressed persons were found particularly for medial and dorsolateral prefrontal and insular activations.

Conclusions

Brain activation in depression during expecting events of unknown emotional valence was comparable with activation while expecting certainly negative, but not positive events. This neurobiological finding is consistent with cognitive models supposing that depressed patients develop a ‘pessimistic’ attitude towards events with an unknown emotional meaning. Thereby, particularly the role of brain areas associated with the processing of cognitive and executive control and of the internal state is emphasized in contributing to major depression.

Copyright
Corresponding author
*Address for correspondence: U. Herwig, M.D., M.A., Psychiatric University Hospital, University of Zürich, Lenggstrasse 31, CH – 8032 Zürich, Switzerland. (Email: uwe.herwig@puk.zh.ch)
References
Hide All
Abler B, Erk S, Herwig U, Walter H (2006). Anticipation of aversive stimuli activates extended amygdala in unipolar depression. Journal of Psychiatric Research 41, 511522.
Anderson AK, Christoff K, Stappen I, Panitz D, Ghahremani DG, Glover G, Gabrieli JD, Sobel N (2003). Dissociated neural representations of intensity and valence in human olfaction. Nature Neuroscience 6, 196202.
Annett M (1967). The binomial distribution of right, mixed and left handedness. Quarterly Journal of Experimental Psychology 19, 327333.
Baxter LR Jr, Schwartz JM, Phelps ME, Mazziotta JC, Guze BH, Selin CE, Gerner RH, Sumida RM (1989). Reduction of prefrontal cortex glucose metabolism common to three types of depression. Archives of General Psychiatry 46, 243250.
Beck AT (1967). Depression: Clinical, Experimental and Theoretical Aspects. Harper & Row: New York.
Beck AT, Ward CH, Mendelson M, Mock J, Erbaugh J (1961). An inventory for measuring depression. Archives of General Psychiatry 4, 561571.
Bermpohl F, Pascual-Leone A, Amedi A, Merabet LB, Fregni F, Gaab N, Alsop D, Schlaug G, Northoff G (2006). Dissociable networks for the expectancy and perception of emotional stimuli in the human brain. NeuroImage 30, 588600.
Calder AJ, Lawrence AD, Young AW (2001). Neuropsychology of fear and loathing. Nature Reviews Neuroscience 2, 352363.
Carter CS, Macdonald AM, Botvinick M, Ross LL, Stenger VA, Noll D, Cohen JD (2000). Parsing executive processes: strategic vs. evaluative functions of the anterior cingulate cortex. Proceedings of the National Academy of Sciences of the USA 97, 19441948.
Churchland PS (2002). Self-representation in nervous systems. Science 296, 308310.
Craig AD (2002). How do you feel? Interoception: the sense of the physiological condition of the body. Nature Reviews Neuroscience 3, 655666.
Critchley HD, Wiens S, Rotshtein P, Ohman A, Dolan RJ (2004). Neural systems supporting interoceptive awareness. Nature Neuroscience 7, 189195.
Damasio AR, Grabowski TJ, Bechara A, Damasio H, Ponto LL, Parvizi J, Hichwa RD (2000). Subcortical and cortical brain activity during the feeling of self-generated emotions. Nature Neuroscience 3, 10491056.
Dannlowski U, Ohrmann P, Bauer J, Deckert J, Hohoff C, Kugel H, Arolt V, Heindel W, Kersting A, Baune BT, Suslow T (2008). 5-HTTLPR biases amygdala activity in response to masked facial expressions in major depression. Neuropsychopharmacology 33, 418424.
Davidson RJ, Irwin W, Anderle MJ, Kalin NH (2003). The neural substrates of affective processing in depressed patients treated with venlafaxine. American Journal of Psychiatry 160, 6475.
Davidson RJ, Pizzagalli D, Nitschke JB, Putnam K (2002). Depression: perspectives from affective neuroscience. Annual Reviews of Psychology 53, 545574.
Drevets WC (2001). Neuroimaging and neuropathological studies of depression: implications for the cognitive-emotional features of mood disorders. Current Opinions in Neurobiology 11, 240249.
Erk S, Walter H, Abler B (2008). Age-related physiological responses to emotion anticipation and exposure. Neuroreport 19, 447452.
Fales CL, Barch DM, Rundle MM, Mintun MA, Snyder AZ, Cohen JD, Mathews J, Sheline YI (2008). Altered emotional interference processing in affective and cognitive-control brain circuitry in major depression. Biological Psychiatry 63, 377384.
Fuster JM (2000). Executive frontal functions. Experimental Brain Research 133, 6670.
Gibson B, Sanbonmatsu DM (2004). Optimism, pessimism, and gambling: the downside of optimism. Personality and Social Psychology Bulletin 30, 149160.
Gilbert DT, Wilson TD (2007). Prospection: experiencing the future. Science 317, 13511354.
Glover GH (1999). Deconvolution of impulse response in event-related BOLD fMRI. NeuroImage 9, 416429.
Grimm S, Beck J, Schuepbach D, Hell D, Boesiger P, Bermpohl F, Niehaus L, Boeker H, Northoff G (2008). Imbalance between left and right dorsolateral prefrontal cortex in major depression is linked to negative emotional judgment: an fMRI study in severe major depressive disorder. Biological Psychiatry 63, 369376.
Gross JJ, John OP (2003). Individual differences in two emotion regulation processes: implications for affect, relationships, and well-being. Journal of Personality and Social Psychology 85, 348362.
Hamilton M (1960). A rating scale for depression. Journal of Neurology, Neurosurgery, and Psychiatry 23, 5662.
Harvey PO, Fossati P, Pochon JB, Levy R, Lebastard G, Lehericy S, Allilaire JF, Dubois B (2005). Cognitive control and brain resources in major depression: an fMRI study using the n-back task. NeuroImage 26, 860869.
Heimer L, Van Hoesen GW (2006). The limbic lobe and its output channels: implications for emotional functions and adaptive behaviour. Neuroscience and Biobehavioral Reviews 30, 126147.
Herwig U, Baumgartner T, Kaffenberger T, Bruhl A, Kottlow M, Schreiter-Gasser U, Abler B, Jancke L, Rufer M (2007 a). Modulation of anticipatory emotion and perception processing by cognitive control. NeuroImage 37, 652662.
Herwig U, Kaffenberger T, Baumgartner T, Jancke L (2007 b). Neural correlates of a ‘pessimistic’ attitude when anticipating events of unknown emotional valence. NeuroImage 34, 848858.
Horn KM, Pong M, Batni SR, Levy SM, Gibson AR (2002). Functional specialization within the cat red nucleus. Journal of Neurophysiology 87, 469477.
Johnstone T, van Reekum CM, Urry HL, Kalin NH, Davidson RJ (2007). Failure to regulate: counterproductive recruitment of top-down prefrontal-subcortical circuitry in major depression. Journal of Neuroscience 27, 88778884.
Keedwell PA, Andrew C, Williams SC, Brammer MJ, Phillips ML (2005). The neural correlates of anhedonia in major depressive disorder. Biological Psychiatry 58, 843853.
Knutson B, Bhanji JP, Cooney RE, Atlas LY, Gotlib IH (2008). Neural responses to monetary incentives in major depression. Biological Psychiatry 63, 686692.
Lang PJ (1995). The emotion probe. Studies of motivation and attention. American Psychologist 50, 372385.
Langenecker SA, Kennedy SE, Guidotti LM, Briceno EM, Own LS, Hooven T, Young EA, Akil H, Noll DC, Zubieta JK (2007). Frontal and limbic activation during inhibitory control predicts treatment response in major depressive disorder. Biological Psychiatry 62, 12721280.
Lavender A, Watkins E (2004). Rumination and future thinking in depression. British Journal of Clinical Psychology 43, 129142.
Lee BT, Seong Whi C, Hyung Soo K, Lee BC, Choi IG, Lyoo IK, Ham BJ (2007). The neural substrates of affective processing toward positive and negative affective pictures in patients with major depressive disorder. Progress in Neuropsychopharmacology and Biological Psychiatry 31, 14871492.
Leppanen JM (2006). Emotional information processing in mood disorders: a review of behavioral and neuroimaging findings. Current Opinions in Psychiatry 19, 3439.
Mayberg HS (2003). Positron emission tomography imaging in depression: a neural systems perspective. Neuroimaging Clinics of North America 13, 805815.
McClure SM, York MK, Montague PR (2004). The neural substrates of reward processing in humans: the modern role of fMRI. Neuroscientist 10, 260268.
Mitterschiffthaler MT, Williams SC, Walsh ND, Cleare AJ, Donaldson C, Scott J, Fu CH (2008). Neural basis of the emotional Stroop interference effect in major depression. Psychological Medicine 38, 247256.
Montgomery SA, Åsberg M (1979). A new depression scale designed to be sensitive to change. British Journal of Psychiatry 134, 382389.
Nesse RM (2000). Is depression an adaptation? Archives of General Psychiatry 57, 1420.
Nichols T, Brett M, Andersson J, Wager T, Poline JB (2005). Valid conjunction inference with the minimum statistic. NeuroImage 25, 653660.
Nitschke JB, Sarinopoulos I, Mackiewicz KL, Schaefer HS, Davidson RJ (2006). Functional neuroanatomy of aversion and its anticipation. NeuroImage 29, 106116.
Norem JK, Cantor N (1986). Defensive pessimism: harnessing anxiety as motivation. Journal of Personality and Social Psychology 51, 12081217.
Northoff G, Bermpohl F (2004). Cortical midline structures and the self. Trends in Cognitive Sciences 8, 102107.
Panksepp J (2006). Emotional endophenotypes in evolutionary psychiatry. Progress in Neuropsychopharmacology and Biological Psychiatry 30, 774784.
Paulus MP, Feinstein JS, Castillo G, Simmons AN, Stein MB (2005). Dose-dependent decrease of activation in bilateral amygdala and insula by lorazepam during emotion processing. Archives of General Psychiatry 62, 282288.
Paulus MP, Stein MB (2006). An insular view of anxiety. Biological Psychiatry 60, 383387.
Pessoa L (2008). On the relationship between emotion and cognition. Nature Reviews Neuroscience 9, 148158.
Phillips ML, Drevets WC, Rauch SL, Lane R (2003). Neurobiology of emotion perception II: Implications for major psychiatric disorders. Biological Psychiatry 54, 515528.
Pyszczynski T, Holt K, Greenberg J (1987). Depression, self-focused attention, and expectancies for positive and negative future life events for self and others. Journal of Personality and Social Psychology 52, 994–1001.
Sharot T, Riccardi AM, Raio CM, Phelps EA (2007). Neural mechanisms mediating optimism bias. Nature 450, 102105.
Shepperd JA, McNulty JK (2002). The affective consequences of expected and unexpected outcomes. Psychological Science 13, 8588.
Siegle GJ, Thompson W, Carter CS, Steinhauer SR, Thase ME (2007). Increased amygdala and decreased dorsolateral prefrontal BOLD responses in unipolar depression: related and independent features. Biological Psychiatry 61, 198209.
Simmons A, Matthews SC, Paulus MP, Stein MB (2008). Intolerance of uncertainty correlates with insula activation during affective ambiguity. Neuroscience Letters 430, 9297.
Soares JC, Mann JJ (1997). The anatomy of mood disorders – review of structural neuroimaging studies. Biological Psychiatry 41, 86–106.
Sporns O, Honey CJ, Kotter R (2007). Identification and classification of hubs in brain networks. PLoS ONE 2, e1049.
Talairach J, Tournoux P (1988). Co-planar Stereotaxic Atlas of the Human Brain. Thieme: Stuttgart.
Vogt BA (2005). Pain and emotion interactions in subregions of the cingulate gyrus. Nature Reviews Neuroscience 6, 533544.
Yamasaki H, LaBar KS, McCarthy G (2002). Dissociable prefrontal brain systems for attention and emotion. Proceedings of the National Academy of Sciences of the USA 99, 1144711451.
Yuste R, MacLean JN, Smith J, Lansner A (2005). The cortex as a central pattern generator. Nature Reviews Neuroscience 6, 477483.
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