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Preliminary Communication Thyro-endocrine pathology, obstetric morbidity and schizophrenia: survey of a hundred families with a schizophrenic proband

  • David MacSweeney (a1), Pauline Timms (a1) and Anthony Johnson (a1)

This preliminary communication reports that the mothers of 104 schizophrenic patients had: (1) a significantly higher incidence of thyroid disease than a carefully matched control group; (2) significantly more abortions, still-births and greater infant mortality. The findings and possible relevance of thyroid disease to schizophrenia are discussed. Three prospective studies currently in progress are outlined.

Corresponding author
1Address for correspondence: Dr David MacSweeney, Academic Department of Psychiatry, Middlesex Hospital Medical School, London W1P 8AA.
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B. W. L. Brooksbank , D. A. MacSweeney , A. L. Johnson , E. Cunningham , D. A. Wilson & A. Coppen (1970). Androgen excretion and physique in schizophrenia. British Journal of Psychiatry 117, 413420.

G. W. Brown , J. L. T. Birley & J. K. Wing (1972). In fluence of family life on the course of schizophrenic disorders: a replication. British Journal of Psychiatry 121, 241258.

E. H. Cranswick (1955). Tracer iodine studies on thyroid activity and thyroid responsiveness in schizophrenia. American Journal of Psychiatry 112, 170178.

D. A. MacSweeney (1970). A report on a pair of male monozygotic twins discordant for schizophrenia. British Journal of Psychiatry 116, 315322.

W. Pollin , J. R. Stabenau , L. Mosher & J. Turpin (1966). Life history differences in identical twins discordant for schizophrenia. American Journal of Orthopsychiatry 36, 492509.

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K. Schneider (1959). Clinical Psychopalhology, 5th edn.Grune and Stratton: New York.

S. Shapiro & R. J. Norman (1967). Thyroxine: effects of neonatal administration on maturation, development and behaviour. Science 155, 12791281.

D. E. Sobel (1961). Infant mortality and malformations in children of schizophrenic women. Psychiatric Quarterly 35, 6065.

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Psychological Medicine
  • ISSN: 0033-2917
  • EISSN: 1469-8978
  • URL: /core/journals/psychological-medicine
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