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The Theory of Multi-Stationary State Transitions and Biosynthetic Control Processes

Published online by Cambridge University Press:  17 March 2009

B. H. Lavenda
B. H. Lavenda
Affiliation:
Department of Physical Chemistry, The Hebrew University, Jerusalem, Israel
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Extract

Factors involved in genetic control of protein synthesis can be classified according to their structural and regulatory roles. The structural constitution of the genetic locus determines the ordering of amino acids in the protein primary structure while regulatory factors influence the rates of protein synthesis. The genetic scheme, proposed by Jacob & Monod (1961), groups genes according to their structural and regulatory functions. This genetic classification alone is insufficient to explain the dynamics of regulatory behaviour. Basic questions such as why cells with the same complement of genes synthesize more of one protein than another are left unanswered. The answers to such questions would shed some light on the dynamical mechanism of tissue differentiation and embryological development. Regulation of protein synthesis should be the result of a combination of structural genetic factors and dynamic biochemical processes. It will be shown in this article that the interaction of structural and dynamic factors leads to a coherent and efficient control mechanism of biosynthesis.

Type
Research Article
Information
Quarterly Reviews of Biophysics , Volume 5 , Issue 4 , November 1972 , pp. 429 - 479
Copyright
Copyright © Cambridge University Press 1972

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