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Are subjective cognitive complaints relevant in preclinical Alzheimer's disease? A review and guidelines for healthcare professionals

  • Ruth E Mark (a1) and Margriet M Sitskoorn (a1)


Identifying what makes people vulnerable to developing Alzheimer's disease (AD) is at the forefront of many research programmes, while early diagnosis is the goal in clinical practice. What individuals themselves tell their general practitioners (GPs) is clearly important because these subjective complaints may be a clue that something is wrong. More specifically, subjective cognitive complaints (SCC) may be the first sign of AD in individuals whose cognitive performance on standard neuropsychological tasks is normal for their age. The challenge for researchers in this field is twofold: (a) determining when SCC do or do not predict current cognitive functioning and future dementia; and (b) estimating how relevant they are for patients and their proxies. The current article addresses these issues, while guidelines are also provided in an attempt to help clinicians interpret and make treatment decisions about their patients’ SCC.


Corresponding author

Address for correspondence: Ruth Elaine Mark, Department of Cognitive Neuropsychology, Tilburg University, Postbox 90153, 5000 LE Tilburg, The Netherlands. Email:


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1van den Dungen, P, van Marwijk, HW, van der Horst, HE, Moll van Charante, EP, Macneil Vroomen, J, van de Ven, PM, van Hout, HP. The accuracy of family physicians’ dementia diagnoses at different stages of dementia: a systematic review. Int J Geriatr Psychiatry 2012; 27: 342–54.
2Alzheimer's Association. Alzheimer's disease facts and figures. Alzheimers Dementia 2012; 8: 131–68.
3Jack, CR Jr, Albert, MS, Knopman, DS, McKhann, GM, Sperling, RA, Carrillo, MC, Thies, B, Phelps, CH. Introduction to the recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimers Dementia 2011; 7: 257–62.
4Sperling, RA, Aisen, PS, Beckett, LA, Bennett, DA, Craft, S, Fagan, AM, Iwatsubo, T, Jack, CR Jr, Kaye, J, Montine, TJ, Park, DC, Reiman, EM, Rowe, CC, Siemers, E, Stern, Y, Yaffe, K, Carrillo, MC, Thies, B, Morrison-Bogorad, M, Wagster, MV, Phelps, CH. Toward defining the preclinical stages of Alzheimer's disease: recommendations from the National Institute on Aging- Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimers Dementia 2011; 7: 280–92.
5Molinuevo, JL, Sánchez-Valle, R, Lladó, A, Fortea, J, Bartrés-Faz, D, Rami, L. Identifying earlier Alzheimer's disease: insights from the preclinical and prodromal phases. Neurodegener Dis 2012; 10: 158–60.
6Khachaturian, AS, Corcoran, CD, Mayer, LS, Zandi, PP, Breitner, J.; Cache County Study Investigators. Apolipoprotein E epsilon4 count affects age at onset of Alzheimer disease, but not lifetime susceptibility: The Cache County Study. Arch Gen Psychiatry 2004; 61: 518–24.
7Jessen, F, Wiese, B, Cvetanovska, G, Fuchs, A, Kaduszkiewicz, H, Kolsch, H, Luck, T, Mosch, E, Pentzek, M, Riedel-Heller, SG, Werle, J, Weyerer, S, Zimmermann, T, Maier, W, Bickel, H. Patterns of subjective memory impairment in the elderly: association with memory performance. Psych Med 2007; 37: 1753–62.
8Barnes, DE, Lee, SJ. Predicting Alzheimer's risk: why and how? Alzheimers Res Ther 2011; 3: 33.
9Bateman, RJ, Xiong, C, Benzinger, TL, Fagan, AM, Goate, A, Fox, NC, Marcus, DS, Cairns, NJ, Xie, X, Blazey, TM, Holtzman, DM, Santacruz, A, Buckles, V, Oliver, A, Moulder, K, Aisen, PS, Ghetti, B, Klunk, WE, McDade, E, Martins, RN, Masters, CL, Mayeux, R, Ringman, JM, Rossor, MN, Schofield, PR, Sperling, RA, Salloway, S, Morris, JC; Dominantly Inherited Alzheimer Network. Clinical and biomarker changes in dominantly inherited Alzheimer's disease. N Engl J Med 2012; 367: 795804.
10Kimchi, E, Desai, AK, Grossberg, GT. New Alzheimer's disease guidelines: Implications for clinicians. Curr Psychiatry 2012; 11: 1520.
11Editorial. A grand plan for Alzheimer's disease and related dementias. Lancet Neurology 2012; 11: 201.
12Gauthier, S, Reisberg, B, Zaudig, M, Petersen, RC, Ritchie, K, Broich, K, Belleville, S, Brodaty, H, Bennett, D, Chertkow, H, Cummings, JL, de Leon, M, Feldman, H, Ganguli, M, Hampel, H, Scheltens, P, Tierney, MC, Whitehouse, P, Winblad, B. International Psychogeriatric Association Expert Conference on mild cognitive impairment. Lancet 2006; 367:1262–70.
13Petersen, RC, Smith, GE, Waring, SC, Ivnik, RJ, Tangalos, EG, Kokmen, E. Mild cognitive impairment: clinical characterization and outcome. Arch Neurol 1999; 56: 303–8.
14Roberto, KA, Blieszner, R, McCann, BR, McPherson, MC. Family triad perceptions of mild cognitive impairment. J Gerontol B Psychol Sci Soc Sci 2011; 66: 756–68.
15Malek-Ahmadi, M, Davis, K, Belden, CM, Jacobson, S, Sabbagh, MN. Informant-reported cognitive symptoms that predict amnestic mild cognitive impairment. BMC Geriatrics 2012b; 12: 3.
16Abbate, C, Trimarchi, PD, Nicolini, P, Bergamaschini, L, Vergani, C, Mari, D. Comparison of informant reports and neuropsychological assessment in mild cognitive impairment. Am J Alzheimers Dis Other Demen 2011; 26: 528–34.
17Jonker, C, Launer, LJ, Hooijer, C, Lindeboom, J. Memory complaints and memory impairment in older individuals. J Am Geriatr Soc 1996; 44: 4449.
18Desai, AK, Schwarz, L. Subjective cognitive impairment: When to be concerned about ‘senior moments’. Curr Psychiatry Online 2011; 10: 3145.
19Doaga, A, Lee, TJ, Russell, R, Nair, R. Clinical inquiries. What could be behind your elderly patient's subjective memory complaints? J Fam Pract 2008; 57: 333–35.
20National Dementia Strategy. Living well with dementia. Department of Health, 2009.
21US Preventive Services Task Force. Screening for dementia: recommendation and rationale summary for patients. Ann Intern Med 2003; 138: 925–26.
22Weyer Jamora, C, Young, A, Ruff, R. Comparison of subjective cognitive complaints with neuropsychological tests in individuals with mild versus more severe traumatic brain injuries. Brain Inj 2012; 26: 3647.
23Paradise, MB, Glozier, NS, Naismith, SL, Davenport, TA, Hickie, IB. Subjective memory complaints, vascular risk factors and psychological distress in the middle-aged: a cross-sectional study. BMC Psychiat 2011: 11: 108.
24Roberts, RO, Geda, YE, Knopman, DS, Cha, RH, Pankratz, VS, Boeve, BF, Ivnik, RJ, Tangalos, EG, Petersen, RC, Rocca, WA. The Mayo Clinic Study of Aging: design and sampling, participation, baseline measures and sample characteristics. Neuroepid 2008; 30: 5869.
25Heun, R, Kölsch, H, Jessen, F. Risk factors and early signs of Alzheimer's disease in a family study sample. Eur Arch Psychiatry Clin Neurosci 2006; 256: 2836.
26Appels, BA, Scherder, E. The diagnostic accuracy of dementia-screening instruments with an administration time of 10 to 45 minutes for use in secondary care: a systematic review. Am J Alzheimers Dis Other Demen 2010; 25: 301–16.
27Bradford, A, Kunik, M, Schulz, P, Williams, S, Singh, H. Missed and delayed diagnosis of dementia in primary care: prevalence and contributing factors. Alzheimer Dis Assoc Disord 2009; 23: 306–14.
28Lister, JP, Barnes, CA. Neurobiological changes in the hippocampus during normative aging. Arch Neurol 2009; 6: 829–33.
29Jonker, C, Geerlings, MI, Schmand, B. Are memory complaints predictive for dementia? A review of clinical and population-based studies. Int J Geriatr Psychiatry 2000; 15: 983–91.
30Rouch, I, Anterion, CT, Dauphinot, V, Kerleroux, J, Roche, F, Barthelemy, JC, Laurent, B. Cognitive complaints, neuropsychological performance and affective disorders in elderly community residents. Disability Rehabil 2008; 30: 1794–802.
31Abdulrab, K, Heun, R. Subjective memory impairment. A review of its definitions indicates the need for a comprehensive set of standardised and validated criteria. Eur Psychiatry 2008; 23: 321–30.
32Riedel-Heller, SG, Matschinger, H, Angermeyer, MC. Do memory complaints indicate the presence of cognitive impairment? Results of a field study. Eur Arch Psychiatry Clin Neurosci 1999; 249: 197204.
33Schofield, PW, Marder, K, Dooneief, G, Jacobs, DM, Sano, M, Stern, Y. Association of subjective memory complaints with subsequent cognitive decline in community-dwelling elderly individuals with baseline cognitive impairment. Am J Psychiatry 1997; 154: 609–15.
34Tobiansky, R, Blizard, R, Livingston, G, Mann, A. The Gospel Oak Study stage IV: the clinical relevance of subjective memory impairment in older people. Psych Med 1995; 25: 779–86.
35Bassett, SS, Folstein, MF. Memory complaint, memory performance, and psychiatric diagnosis: a community study. J Geriatr Psychiatry Neurol 1993; 6, 105–11.
36Mitchell, AJ. The clinical significance of subjective memory complaints in the diagnosis of mild cognitive impairment and dementia: a meta-analysis. Int J Geriatr Psychiatry 2008; 23: 1191–202.
37Broadbent, DE, Cooper, PF, FitzGerald, P, Parkes, KR. The Cognitive Failures Questionnaire (CFQ) and its correlates. Br J Clin Psychol 1982; 21: 116.
38Gilewski, MJ, Zelinski, EM, Schaie, KW. The Memory Functioning Questionnaire for assessment of memory complaints in adulthood and old age. Psychol Aging 1990; 5: 482–90.
39Crook, TH 3rd, Larrabee, GJA. A self-rating scale for evaluating memory in everyday life. Psychol Aging 1990; 5: 4857.
40McNair, D, Kahn, RJ. Self assessment of cognitive deficits. In Crook, T, Ferris, S, Bartus, R (eds), Assessment in Geriatric Psychopharmacology. New Canaan: Mark Powley Associates, 1983; pp. 137143.
41Sunderland, A, Harris, JE, Baddeley, AD. Do laboratory tests predict everyday memory? A neuropsychological study. J Verbal Learning Verbal Behavior 1983; 22: 727–38.
42Ruff, RM, Hibbard, K. Ruff Neurobehavioral Inventory. Odessa, FL: Psychological Assessment Resources, 2003.
43Malek-Ahmadi, M, Davis, K, Belden, C, Laizure, B, Jacobson, S, Yaari, R, Singh, U, Sabbagh, MN. Validation and diagnostic accuracy of the Alzheimer's questionnaire. Age Ageing 2012; 41: 396–99.
44Roth, M, Huppert, FA, Mountjoy, CQ, Tym, E. Camdex-R: The Cambridge Examination for Mental Disorders of the Elderly-Revised. Cambridge, UK: Cambridge University Press, 1998.
45Clare, L. Awareness in people with severe dementia: review and integration. Aging Mental Health 2010; 14: 2032.
46Jorm, AF, Christensen, H, Korten, AE, Jacomb, PA, Henderson, S. Memory complaints as a precursor of memory impairment in older people: A longitudinal analysis over 7–8 years. Psych Med 2001; 31: 441–49.
47Jungwirth, S, Fischer, P, Weissgram, S, Kirchmeyr, W, Bauer, P, Tragl, K-H. Subjective memory complaints and objective memory impairment in the Vienna-transdanube aging community. J Am Geriatr Soc 2004; 52: 263–68.
48Kliegel, MK, Zimprich, D, Eschen, A. What do subjective cognitive complaints in persons with aging-associated cognitive decline reflect? Intern Psychogeriatrics 2005; 17: 499512.
49Simmons, SF, Johansson, B, Zarit, SH, Ljungquist, B, Plomin, R, McClearn, GE. Selection bias in samples of older twins? A comparison between octogenarian twins and singletons in Sweden. J Aging Health 1997; 9: 553–67.
50Coley, N, Ousset, PJ, Andrieu, S, Matheix Fortunet, H, Vellas, B. Memory complaints to the general practitioner: data from the GuidAge study. J Nutr Health Aging 2008; 12: 6672S.
51Mattos, P, Lino, V, Rizo, L, Alfano, A, Araújo, C, Raggio, R. Memory complaints and test performance in healthy elderly persons. Arq Neuropsiquiatr 2003; 61: 920–24.
52Gagnon, M, Dartigues, JF, Mazaux, JM, Dequae, L, Letenneur, L, Giroire, JM, Barberger-Gateau, P. Self-reported memory complaints and memory performance in elderly French community residents: results of the PAQUID research program. Neuroepid 1994; 13: 145–54.
53Waldorff, FB, Rishoj, S, Waldemar, G. If you don't ask (about memory), they probably won't tell. J Fam Pract 2008; 57: 4144.
54Middleton, LS, Denney, DR, Lynch, SG, Parmenter, B. The relationship between perceived and objective cognitive functioning in multiple sclerosis. Clinical Neuropsychologist 2006; 21: 487–94.
55Zandi, T.Relationship between subjective memory complaints, objective memory performance, and depression among older adults. Am J Alzheimers Dis Other Demen 2004; 19: 353–60.
56Minett, TSC, Da Silva, RV, Ortiz, KZ, Bertolucci, PHF. Subjective memory complaints in an elderly sample: a cross-sectional study. Int J Geriatr Psychiatry 2008; 23: 4954.
57Hohman, TJ, Beason-Held, LL, Resnick, SM. Cognitive complaints, depressive symptoms, and cognitive impairment: are they related? J Am Geriatr Soc 2011; 59: 1908–12.
58Sims, RC, Whitfield, KE, Ayotte, BJ, Gamaldo, AA, Edwards, CL, Allaire, JC. Subjective memory in older African Americans. Exp Aging Res 2011; 37: 220–40.
59Pearman, A, Storandt, M. Predictors of subjective memory in older adults. J Gerontol 2004; 59B: 46.
60Vestberg, S, Passant, U, Risberg, J, Elfgren, C. Personality characteristics and affective status telated to cognitive test performance and gender in patients with memory complaints. J Int Neuropsychol Soc 2007; 13: 911–19.
61Caracciolo, B, Gatz, M, Xu, W, Pedersen, NL, Fratiglioni, L. Differential distribution of subjective and objective cognitive impairment in the population: a nation-wide twin-study. J Alzheimers Dis 2012; 29: 393403.
62Jessen, F, Wiese, B, Bickel, H, Eiffländer-Gorfer, S, Fuchs, A, Kaduszkiewicz, H, Köhler, M, Luck, T, Mösch, E, Pentzek, M, Riedel-Heller, SG, Wagner, M, Weyerer, S, Maier, W, van den Bussche, H. AgeCoDe Study Group. Prediction of dementia in primary care patients. PLoS One 2011; 6: e16852.
63Montejo, P, Montenegro, M, Fernández, MA, Maestú, F. Memory complaints in the elderly: Quality of life and daily living activities. A population based study. Arch Gerontol Geriatr 2012; 54: 298304.
64Turvey, CL, Schultz, S, Arndt, S, Wallace, RB, Herzog, R. Memory complaint in a community sample aged 70 and older. J Am Geriatr Soc 2000; 48: 1435–41.
65Wong, CHY, Lam, LCW, Lui, VWC, Chiu, HFK, Chan, SSM, Tam, CWC. Subjective complaints and self-evaluation of memory test performance in questionable dementia. Int J Geriatr Psychiatry 2006; 21: 937–44.
66Geerlings, MI, Jonker, C, Bouter, LM, Ader, HJ, Schmand, B. Association between memory complaints and incident Alzheimer's disease in elderly people with normal baseline cognition. Am J Psychiatry 1999; 156: 531–37.
67Farrin, L, Hull, L, Unwin, C, Wykes, T, David, A. Effects of depressed mood on objective and subjective measures of attention. J Neuro-psychiatry Clin Neurosci 2003; 15: 98104.
68Binder, LM, Storzbach, D, Anger, WK, Campbell, KA, Rohlman, DS, of the Portland Environmental OM, Center HR; Portland Environmental Hazards Research Center. Subjective cognitive complaints, affective distress, and objective cognitive performance in Persian Gulf War veterans. Arch Clin Neuropsychol 1999; 14: 531–36.
69Yesavage, JA, Brink, TL, Rose, TL, Lum, O, Huang, V, Adey, M, Leirer, VO. Development and validation of a geriatric depression screening scale: a preliminary report. J Psychiatr Res 1983; 17: 3749.
70Wolf, OT, Dziobek, I, McHugh, P, Sweat, V, de Leon, MJ, Javier, E, Convit, A. Subjective memory complaints in aging are associated with elevated cortisol levels. Neurobiol Aging 2005; 26: 1357–63.
71Dave, JB. Accuracy of subjective cognitive complaints in a longitudinal context: the effect of depression and dementia status. PhD dissertation (Psychology, University of Southern California), 2009. Available at:
72Panza, F, Frisardi, V, Capurso, C, D'Introno, A, Colacicco, AM, Imbimbo, BP, Santamato, A, Vendemiale, G, Seripa, D, Pilotto, A, Capurso, A, Solfrizzi, V. Late-life depression, mild cognitive impairment, and dementia: possible continuum? Am J Geriatr Psychiatry 2010; 18: 98116.
73Minett, TS, Dean, JL, Firbank, M, English, P, O'Brien, JT. Subjective memory complaints, white-matter lesions, depressive symptoms, and cognition in elderly patients. Am J Geriatr Psychiatry 2005; 13: 665–71.
74von Gunten, A, Ron, MA. Hippocampal volume and subjective memory impairment in depressed patients. Eur Psychiatry 2004; 19: 438–40.
75van der Flier, WM, Pijnenburg, YA, Schoonenboom, SN, Dik, MG, Blankenstein, MA, Scheltens, P. Distribution of APOE genotypes in a memory clinic cohort. Dement Geriatr Cogn Disord 2008; 25: 433–38.
76Barnes, LL, Schneider, JA, Boyle, PA, Bienias, JL, Bennett, DA. Memory complaints are related to Alzheimer disease pathology in older persons. Neurology 2006; 67: 1581–85.
77Perrotin, A, Mormino, EC, Madison, CM, Hayenga, AO, Jagust, WJ. Subjective cognition and amyloid deposition imaging: a Pittsburgh Compound B positron emission tomography study in normal elderly individuals. Arch Neurol 2012; 69: 223–29.
78Mosconi, L, Pupi, A, De Leon, MJ. Brain glucose hypometabolism and oxidative stress in preclinical Alzheimer's disease. Ann NY Acad Sci 2008; 1147: 180–95.
79Schoo, LA, van den Berg, E, van Zandvoort, MJ, Postma, A. Do you know what I mean? Laypeople and experts’ concepts of cognition. Arch Clin Neuropsychol 2012; 27: 182–89.
80Holmen, K, Ericsson, K, Winblad, B. Quality of life among the elderly: state of mood and loneliness in two selected groups. Scand J Car Sci 1999; 13: 9195.
81Di Carlo, A, Baldereschi, M, Amaducci, L, Maggi, S, Grigoletto, F, Scarlato, G, Inzitari, D. Cognitive impairment without dementia in older people: prevalence, vascular risk factors, impact on disability: the Italian Longitudinal Study on Aging. J Am Geriatr Soc 2000; 48: 775–82.
82Black, BS, Rabins, PV, German, PS. Predictors of nursing home placement among elderly public housing residents. Gerontologist 1999; 39: 559–68.
83West, RL, Dennehy-Basile, D, Norris, MP. Memory self-evaluation: The effects of age and experience. Aging Neuropsychol Cogn 1996; 3:6783
84Carter, SL, Rourke, SB, Murji, S, Shore, D, Rourke, BP. Cognitive complaints, depression, medical symptoms, and their association with neuropsychological functioning in HIV infection: a structural equation model analysis. Neuropsychology 2003; 17: 410–19.
85Reid, LM, Maclullich, AM. Subjective memory complaints and cognitive impairment in older people. Dement Geriatr Cogn Disord 2006; 22: 471–85.
86Metternich, B, Schmidtke, K, Hull, M. How are memory complaints in functional memory disorder related to measures of affect, metamemory and cognition? J Psychosom Res 2009; 66: 435–44.
87Rodda, JE, Dannhauser, TM, Cutinha, DJ, Shergill, SS, Walker, Z. Subjective cognitive impairment: increased prefrontal cortex activation compared to controls during an encoding task. Int J Geriatr Psychiatry 2009; 24: 865–74.
88Palmer, K, Bäckman, L, Winblad, B, Fratiglioni, L. Detection of 2 Alzheimer's disease and dementia in the preclinical phase: population based cohort study. BMJ 2003; 326: 245.
89Iliffe, S, Pealing, L. Subjective memory problems. BMJ 2010; 19: 703–6.
90Witt, JA, Glöckner, C, Helmstaedter, C. Extended retention intervals can help to bridge the gap between subjective and objective memory impairment. Seizure 2012; 21: 134–40.
91Armistead-Jehle, P, Gervais, RO, Green, P. Memory complaints inventory results as a function of symptom validity test performance. Arch Clin Neuropsychol 2012; 27: 101–13.
92Zelinski, EM, Burnight, KP, Lane, CJ. The relationship between subjective and objective memory in the oldest-old: Comparisons of findings from a representative and a convenience sample. J Aging Health 2001; 13: 248–66.
93Helmstaedter, C, Hauff, M, Elger, CE. Ecological validity of list-learning tests and self-reported memory in healthy individuals and those with temporal lobe epilepsy. J Clin Exp Neuropsychol 1998; 30: 111.
94Bruckner, RL. Memory and executive function in aging and AD: multiple factors that cause decline and reserve factors that compensate. Neuron 2004; 44: 195206.
95Martins, IP, Mares, I, Stilwell, PA. How subjective are subjective language complaints. Eur J Neurol 2012; 19: 666–71.
96Snitz, BE, Yu, L, Crane, PK, Chang, CC, Hughes, TF, Ganguli, M. Subjective cognitive complaints of older adults at the population level: an item response theory analysis. Alzheimer Dis Assoc Disord 2011; Epub ahead of print: doi 10.1097/WAD.0b013e3182420bdf.
97Amariglio, RE, Townsend, MK, Grodstein, F, Sperling, RA, Rentz, DM. Specific subjective memory complaints in older persons may indicate poor cognitive function. J Am Geriatr Soc 2011; 59: 1612–17.
98Calero-García, MD, Navarro-González, E, Gómez-Ceballos, L, López Pérez-Díaz, A, Torres-Carbonell, I, Calero-García, MJ. [Memory lapses and memory: relationship between objective and subjective memory in old age.] Revista Espanola de Geriatria y Gerontologia 2008; 43: 299307. [Spanish].
99McGlone, J, Gupta, S, Humphrey, D, Oppenheimer, S, Mirsen, T, Evans, DR. Screening for early dementia using memory complaints from patients and relatives. Arch Neurol 1990; 47: 1189–93.
100Kahn, RL, Zarit, SH, Hilbert, NM, Niederehe, G. Memory complaint and impairment in the aged: the effect of depression and altered brain function. Arch Gen Psychiatry 1975; 32: 1569–73.
101Williams, JM, Little, MM, Scates, S, Blockman, N. Memory complaints and abilities among depressed older adults. J Consult Clin Psychol 1987; 55: 595–98.
102Bolla, KI, Lindgren, KN, Bonaccorsy, C, Bleecker, ML. Memory complaints in older adults: fact or fiction? Arch Neurol 1991; 48: 6164.
103van Oijen, M, de Jong, FJ, Hofman, A, Koudstaal, PJ, Breteler, MM. Subjective memory complaints, education, and risk of Alzheimer's disease. Alzheimers Dementia 2007; 3: 9297.
104Kivipelto, M, Ngandu, T, Laatikainen, T, Winblad, B, Soininen, H, Tuomilehto, J. Risk score for the prediction of dementia risk in 20 years among middle aged people: a longitudinal, population-based study. Lancet Neurology 2006; 5: 735–41.
105Barnes, DE, Covinsky, KE, Whitmer, RA, Kuller, LH, Lopez, OL, Yaffe, K. Predicting risk of dementia in older adults: The late-life dementia risk index. Neurology 2009; 73: 173–79.
106Begum, A, Morgan, C, Chiu, CC, Tylee, A, Stewart, R. Subjective memory impairment in older adults: aetiology, salience and help seeking. Int J Geriatr Psychiatry 2012; 27: 612–20.
107French, SL, Floyd, M, Wilkins, S, Osato, S. The Fear of Alzheimer's Disease Scale: a new measure designed to assess anticipatory dementia in older adults. Int J Geriatr Psychiatry 2012; 27: 521–28.
108Mol, M, Ruiter, R, Verhey, F, Dijkstra, J, Jolles, L. A study into the psychosocial determinants of perceived forgetfulness: implications for future interventions. Aging Mental Health 2008; 12: 167–76.
109Waldorff, FB, Siersma, V, Vogel, A, Waldemar, G. Subjective memory complaints in general practice predicts future dementia: a 4-year follow-up study. Int J Geriatr Psychiatry 2012; 27: 1180–88.
110Metternich, B, Kosch, D, Kriston, L, Härter, M, Hüll, M. The effects of non-pharmacological interventions on subjective memory complaints: a systematic review and meta-analysis. Psychother Psychosom 2010; 79: 619.
111Richardson, JTE, Chan, RCB. The constituent structure of subjective memory questionnaires: Evidence from multiple sclerosis. Memory 1995; 3: 187200.
112Onor, ML, Trevisiol, M, Negro, C, Aguglia, E. Different perception of cognitive impairment, behavioral disturbances, and functional disabilities between persons with mild cognitive impairment and mild Alzheimer's disease and their caregivers. Am J Alzheimers Dis Other Demen 2006; 21: 333–38.
113Carr, DB, Gray, S, Baty, J, Morris, JC. The value of informant versus individual's complaints of memory impairment in early dementia. Neurology 2000; 55: 1724–26.
114Rayner, G, Wrench, JM, Wilson, SJ. Differential contributions of objective memory and mood to subjective memory complaints in refractory focal epilepsy. Epilepsy Behavior 2010; 19: 359–64.
115Pennbrant, S, Pilhammar Andersson, E, Nilsson, K. Elderly patients’ experiences of meeting with the doctor: a sociocultural study in a hospital setting in Sweden. Research Aging 2012; first published 9 February: doi 10.1177/0164027512436430.
116Artero, S, Ritchie, K. The detection of mild cognitive impairment in the general practice setting. Aging Mental Health 2003; 7: 251–58.
117Jessen, F, Wiese, B, Bachmann, C, Eifflaender-Gorfer, S, Haller, F, Kolsch, H, Luck, T, Mosch, E, van den Bussche, H, Wagner, M, Wollny, A, Zimmermann, T, Pentzek, M, Riedel-Heller, SG, Romberg, HP, Weyerer, S, Kaduszkiewicz, H, Maier, W, Bickel, H. Prediction of dementia by subjective memory impairment: Effects of severity and temporal association with cognitive impairment. Arch Gen Psychiatry 2010; 67: 414–22.
118Reisberg, B, Shulman, MB, Torossian, C, Leng, L, Zhu, W. Outcome over seven years of healthy adults with and without subjective cognitive impairment. Alzheimers Dementia 2010; 6: 1124.
119Cappa, SF. Subjective cognitive complaints: not to be dismissed. Eur J Neurol 2012; 9: 665.



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