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Different Effects of Trifluoperazine when Administered Daytime or Night

Published online by Cambridge University Press:  29 January 2018

N. Polvan ,
S. Akpinar ,
M. B. Ahmed  and
T. M. Itil
N. Polvan
Affiliation:
From the Department of Neuropsychiatry, Cerrahpasa Medical Faculty, University of Istanbul, Istanbul, Turkey
S. Akpinar
Affiliation:
From the Department of Psychiatry of the University of Missouri School of Medicine, at the Missouri Institute of Psychiatry, 5400 Arsenal Street, St. Louis, Missouri
M. B. Ahmed
Affiliation:
St. Louis State Hospital Complex, 5400 Arsenal Street, St. Louis, Missouri
T. M. Itil
Affiliation:
From the Department of Psychiatry of the University of Missouri School of Medicine, at the Missouri Institute of Psychiatry, 5400 Arsenal Street, St. Louis, Missouri
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Extract

The neuroleptics which are very effective in chronic schizophrenia, such as fluphenazine, thiothixene and haloperidol, have both central ‘inhibitory’ and 'stimulatory’ properties (Itil et al., 1969, 1970). When chronically administered in low dosages, these compounds decrease Stage 4 of the sleep process and produce insomnia, while in high dosages they produce deeper sleep stages. Based on these observations and the fact that extrapyramidal symptoms usually do not occur during deep sleep, we hypothesized that high oral doses of trifluoperazine given at night would produce fewer sleep disturbances and extrapyramidal symptoms than the same dosages of this compound administered during the morning.

Type
Abstract
Information
The British Journal of Psychiatry , Volume 119 , Issue 553 , December 1971 , pp. 601 - 602
Copyright
Copyright © Royal College of Psychiatrists, 1971 

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References

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