Skip to main content
×
×
Home

Affective modulation of anterior cingulate cortex in young people at increased familial risk of depression

  • Zola N. Mannie (a1), Ray Norbury (a1), Susannah E. Murphy (a1), Becky Inkster (a1), Catherine J. Harmer (a1) and Philip J. Cowen (a1)...
Abstract
Background

We previously found that children of parents with depression showed impaired performance on a task of emotional categorisation.

Aims

To test the hypothesis that children of parents with depression would show abnormal neural responses in the anterior cingulate cortex, a brain region involved in the integration of emotional and cognitive information.

Method

Eighteen young people (mean age 19.8 years) with no personal history of depression but with a biological parent with a history of major depression (FH+ participants) and 16 controls (mean age 19.9 years) underwent functional magnetic resonance imaging while completing an emotional counting Stroop task.

Results

Controls showed significant activation in the pregenual anterior cingulate cortex to both positive and negative words during the emotional Stroop task. This activation was absent in FH+ participants.

Conclusions

Our findings show that people at increased familial risk of depression demonstrate impaired modulation of the anterior cingulate cortex in response to emotionally valenced stimuli.

    • Send article to Kindle

      To send this article to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle. Find out more about sending to your Kindle.

      Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      Affective modulation of anterior cingulate cortex in young people at increased familial risk of depression
      Available formats
      ×
      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Dropbox.

      Affective modulation of anterior cingulate cortex in young people at increased familial risk of depression
      Available formats
      ×
      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Google Drive.

      Affective modulation of anterior cingulate cortex in young people at increased familial risk of depression
      Available formats
      ×
Copyright
Corresponding author
Professor PJ Cowen, Neurosciences Building, Warneford Hospital, Oxford OX3 7JX, UK Email: phil.cowen@psych.ox.ac.uk
Footnotes
Hide All

Declaration of interest

None.

Funding detailed in Acknowledgement.

Footnotes
References
Hide All
1 Mannie, ZN, Bristow, GC, Harmer, CJ, Cowen, PJ. Impaired emotional categorisation in young people at increased familial risk of depression. Neuropsychologia 2007; 45: 2975–80.
2 Bush, G, Luu, P, Osner, MI. Cognitive and emotional influences in anterior cingulate cortex. Trends Cog Soc 2000; 4: 215–22.
3 Kerns, JG, Cohen, JD, MacDonald, AW, Cho, RY, Stenger, VA, Carter, CS. Anterior cingulate conflict monitoring. Science 2004; 1023: 126.
4 Whalen, PJ, Bush, G, McNally, RJ, Wilhelm, S, McInerney, , Jenike, MA, Rausch, SL. The emotional counting Stroop paradigm. A functional magnetic resonance imaging probe of the anterior cingulate affective division. Biol Psychiatry 1998; 44: 1219–28.
5 Spitzer, RL, Williams, JB, Gibbon, M, First, MB. Structured Clinical Interview for the DSM– IV (SCID– I/P). American Psychiatric Press, 2004.
6 Andreason, NC, Rice, J, Endicott, J, Reich, T, Coryell, W. The family history approach to diagnosis. How useful is it? Arch Gen Psychiatry 1986; 43: 421–9.
7 Oldfield, RC. The assessment and analysis of handedness: the Edinburgh inventory. Neuropsychologia 1971; 9: 97113.
8 Wood, A, Kroll, L, Moore, A, Harrington, R. Properties of the Mood and Feelings Questionnaire in adolescent psychiatric outpatients: a research note. J Child Psychol 1995; 36: 327–34.
9 Zigmond, AS, Snaith, RP. The Hospital Anxiety and Depression scale. Acta Psychiatr Scand 1983; 67: 361–70.
10 Cohen, S, Kamarck, T, Mermelstein, R. A global measure of perceived stress. J Health Soc Behav 1983; 24: 386–96.
11 Parker, G. Parental characteristics in relation to depressive disorders. Br J Psychiatry 1979; 134: 138–47.
12 Goodyer, IM, Herbert, J, Tamplin, A, Secher, S, Pearson, J. Short-term outcome of major depression: II. Life events, family dysfunction, and friendship difficulties as predictors of persistent disorder. J Am Acad Child Adolesc Psych 1997; 36: 474–80.
13 Mathews, A, Mogg, K, May, J, Eysenck, M. Implicit and explicit memory bias in anxiety. J Abnorm Psychol 1989; 98: 236–40.
14 Smith, SM, Jenkinson, M, Woolrich, MW, Beckmann, CF, Behrens, TEJ, Johansen-Berg, H, Bannister, PR, DE Luca, M, Drobnjak, I, Flitney, DE, Niazy, RK, Saunders, J, Vickers, J, Zhang, Y, De Stefano, , Brady, JM, Matthews, PM. Advances in functional and structural MR image analysis and implementation as FSL. Neuroimage 2004; 23: S20819.
15 Jenkinson, M, Bannister, P, Brady, M, Smith, SM. Improved optimization for the robust and accurate linear registration and motion correction of brain images. Neuroimage 2002; 1: 7825–41.
16 Smith, SM. Fast robust automated brain extraction. Hum Brain Mapp 2002; 17: 143–55.
17 Jenkinson, M, Smith, SM. A global optimisation method for robust affine registration of brain images. Med Image Ana 2001; 5: 143–56.
18 Woolrich, MW, Ripley, BD, Brady, M, Smith, SM. Temporal autocorrelation in univariate linear modeling of FMRI data. Neuroimage 2001; 14: 1370–86.
19 Woolrich, MW, Behrens, TE, Beckmann, CF, Jenkinson, M, Smith, SM. Multilevel linear modeling for fMRI group analysis using Bayesian inference. Neuroimage 2004; 21: 1732–47.
20 Friston, KJ, Worsley, KJ, Frackowiak, RS, Mazziotti, JC, Evans, AC. Assessing the significance of focal activations using their spatial extent. Hum Brain Mapp 1994; 1: 210–20.
21 Mannie, ZN, Harmer, CJ, Cowen, PJ. Increased waking salivary cortisol levels in young people at familial risk of depression. Am J Psychiatry 2007; 164: 617–21.
22 Beardslee, WR, Versage, EM, Gladstone, TR. Children of affectively ill parents: a review of the past 10 years. Am J Adolesc Psychiatry 1998; 37: 1134–41.
23 Elliott, R, Rubinsztein, JS, Sahakian, BJ. Dolan, RJ. Selective attention to emotional stimuli in a verbal go/no-go task: an fMRI study. Neuroreport 2000; 11: 1739–80.
24 Elliott, R, Baker, SC, Rogers, RD, O'Leary, DA, Paykel, ES, Frith, CD, Dolan, RJ, Sahakian, BJ. Prefrontal dysfunction in depressed patients performing a complex planning task. A study using positron emission tomography. Psychol Med 1997; 27: 931–42.
25 Davidson, RJ, Pizzagalli, D, Nitscke, JB, Putnam, K. Depression: perspectives from affective neuroscience. Ann Rev Psychol 2002; 53: 545–74.
26 Wagner, G, Sinsel, E, Sobanski, T, Köhler, V, Marinou, H, Mentzel, H, Sauer, R, Schlösser, RG. Cortical inefficiency in patients with unipolar depression: an event-related FMRI study with the Stroop task. Biol Psychiatry 2006; 59: 5865.
27 Fu, CH, Williams, SC, Cleare, AJ, Brammer, MJ, Walsh, ND, Kim, J, Andrew, CM, Pich, EM, Williams, PM, Reed, LJ, Mitterschiffthaler, , Suckling, J, Bullmore, ET. Attenuation of the neural response to sad faces in major depression by antidepressant treatment. A prospective, event-related functional magnetic resonance imaging study. Arch Gen Psychiatry 2004; 61: 877–89.
28 Elliott, R, Rubinsztein, JS, Sahakian, BJ, Dolan, RJ. The neural basis of mood congruent processing biases in depression. Arch Gen Psychiatry 2002; 59: 597604.
29 Drevets, WC. Neuroimaging studies of mood disorders. Biol Psychiatry 2000, 48: 813–29.
30 Goodyer, IM. Social adversity and mental functions in adolescents at high risk of psychopathology. Position paper and suggested framework for future research. Br J Psychiatry 2002; 181: 383–6.
31 Phillips, ML, Drevets, WC, Rausch, SL, Lane, R. Neurobiology of emotion perception I: the neural basis of normal emotion perception. Biol Psychiatry 2003; 54: 504–14.
32 Phillips, ML, Drevets, WC, Rausch, SL, Lane, R. Neurobiology of emotion perception II: Implications for major psychiatric disorders. Biol Psychiatry 2003; 54: 515–28.
33 Anand, A, Li, Y, Wang, Y, Wu, S, Gao, L, Bukhari, V, Mathews, A, Kalnin, M, Lowe, MJ. Activity and connectivity of brain mood regulating circuit in depression; a functional magnetic resonance imaging study. Biol Psychiatry 2005; 57: 1079–88.
Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

The British Journal of Psychiatry
  • ISSN: 0007-1250
  • EISSN: 1472-1465
  • URL: /core/journals/the-british-journal-of-psychiatry
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×
Type Description Title
PDF
Supplementary materials

Mannie et al. supplementary material
Supplementary Table S1

 PDF (32 KB)
32 KB
UNKNOWN
Supplementary materials

Mannie et al. supplementary material
Supplementary Material

 Unknown (531 bytes)
531 bytes

Metrics

Full text views

Total number of HTML views: 0
Total number of PDF views: 10 *
Loading metrics...

Abstract views

Total abstract views: 42 *
Loading metrics...

* Views captured on Cambridge Core between 2nd January 2018 - 24th April 2018. This data will be updated every 24 hours.

Affective modulation of anterior cingulate cortex in young people at increased familial risk of depression

  • Zola N. Mannie (a1), Ray Norbury (a1), Susannah E. Murphy (a1), Becky Inkster (a1), Catherine J. Harmer (a1) and Philip J. Cowen (a1)...
Submit a response

eLetters

No eLetters have been published for this article.

×

Reply to: Submit a response


Your details


Conflicting interests

Do you have any conflicting interests? *