Hostname: page-component-76dd75c94c-68sx7 Total loading time: 0 Render date: 2024-04-30T07:54:22.327Z Has data issue: false hasContentIssue false
  • English
  • Français

Cytogenetic Studies in the Offspring of Lsd Users

Published online by Cambridge University Press:  29 January 2018

J. Fernandez ,
T. Brennan ,
J. Masterson  and
M. Power
J. Fernandez
Affiliation:
St. Brendan's Hospital, Dublin, 7, Ireland
T. Brennan
Affiliation:
St. Brendan's Hospital, Dublin, 7, Ireland
J. Masterson
Affiliation:
Department of Pathology, University College Dublin, Ireland
M. Power
Affiliation:
Department of Pathology, University College Dublin, Ireland
Get access Rights & Permissions [Opens in a new window]

Extract

The presumed carcinogenic and chromosome-breaking potential of d-lysergic acid diethylamide (d-LSD 25) in human somatic cells has been reviewed by Fernandez et al. (1973). Reports concerning its teratogenic effect in experimental animals and man have been either contradictory or inconclusive. The following possible teratogenic mechanisms may be considered: (1) A direct effect on organogenesis of LSD ingested by the mother during early pregnancy; (2) A similar disturbance of organogenesis by a persistent metabolite of LSD ingested by the mother at some time prior to the pregnancy; (3) Chromosome damage or point mutations in parental germ cells exposed to LSD before initiation of a pregnancy.

Type
Abstract
Information
The British Journal of Psychiatry , Volume 124 , Issue 580 , March 1974 , pp. 296 - 298
Copyright
Copyright © Royal College of Psychiatrists, 1974 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Browning, L. (1968). ‘Lysergic acid diethylamide: mutagenic effects in drosophila.’ Science, 161, 1022–3.Google Scholar
Court Brown, W. M., Buckton, K. E., Jacobs, P. A., Tough, I. M., Kuenssberg, E. V., and Knox, J. E. D., (1966). ‘Chromosome studies on adults’, in Eugenics Laboratory Memoirs, vol. 42, 2–91. London: Cambridge University Press.Google Scholar
Dishotsky, N. I., Loughman, W. D., Mogar, R. E., and lipscombe, W. R. (1971). ‘LSD and genetic damage: is LSD chromosome damaging, carcinogenic, mutagenic or teratogenic.’ Science, 172, 431–40.CrossRefGoogle ScholarPubMed
Fernandez, J., Browne, I. W., Cullen, J., Brennan, T., Matheu, H., Fischer, I., Masterson, J., and Law, E. (1973). ‘LSD: an in-vivo retrospective chromosome study.’ Annals of Human Genetics, 37, 81–91.Google Scholar
Grace, D., Carlson, E. A., and Goodman, P. (1968). ‘Drosophila melanogaster treated with LSD: absence of mutation and chromosome breakage.’ Science, 161, 694–6.CrossRefGoogle ScholarPubMed
Hecht, F., Beals, R. K., Lees, M. H., Jolly, H., and Roberts, P. (1968). ‘Lysergic acid diethylamide and cannabis as possible teratogens in man.’ Lancet, ii, 1087.Google Scholar
Long, S. Y. (1972). ‘Does LSD induce chromosomal damage and malformations: a review of the literature.’ Teratology, 6, 75–90.CrossRefGoogle ScholarPubMed
Second Report of the Committee on the Hazards to Man of Nuclear and Allied Radiations (1968), p. 78. London: H.M.S.O.Google Scholar
Smythies, J. R., and Antun, F. (1969). ‘Binding of tryptamine and allied compounds to nucleic acids.’ Nature, 223, 1061–3.CrossRefGoogle ScholarPubMed
Stanford, R. W., and Vance, J. (1955). ‘Quantity of radiation received by reproduction organs of patients during routine diagnostic X-ray examinations.’ British Journal of Radiology, 27, 266–73.Google Scholar
Tobin, J. M., and Tobin, J. (1969). ‘Mutagenic effects of LSD-25 in drosophila melanogaster.’ Diseases of the Nervous System, 30, 47–52.Google ScholarPubMed
Vann, E. (1969). ‘Lethal mutation rate in drosophila exposed to LSD-25 by injection and ingestion.’ Naturte, 223, 95–96.CrossRefGoogle ScholarPubMed
Wagner, T. E. (1969). ‘In vitro interaction of LSD with purified calf thymus DNA.’ Nature, 222, 1170–72.CrossRefGoogle Scholar
Zetterberg, G. (1969). ‘Lysergic acid diethylamide and mutation.’ Hereditas, 62, 262–64.Google ScholarPubMed
Submit a response

eLetters

No eLetters have been published for this article.