1Manolio, TA, Collins, FS, Cox, NJ, Goldstein, DB, Hindorff, LA, Hunter, DJ, et al. Finding the missing heritability of complex diseases. Nature 2009; 461: 747–53.
2Nishino, J, Kochi, Y, Shigemizu, D, Kato, M, Ikari, K, Ochi, H, et al. Empirical bayes estimation of semi-parametric hierarchical mixture models for unbiased characterization of polygenic disease architectures. Front Genet 2018; 9: 115.
3Cross-Disorder Group of the Psychiatric Genomics Consortium. Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs. Nat Genet 2013; 45: 984–94.
4Visscher, PM, Wray, NR, Zhang, Q, Sklar, P, McCarthy, MI, Brown, MA, et al. 10 years of GWAS discovery: biology, function, and translation. Am J Hum Genet 2017; 101: 5–22.
5Bulik-Sullivan, B, Finucane, HK, Anttila, V, Gusev, A, Day, FR, Loh, PR, et al. An atlas of genetic correlations across human diseases and traits. Nat Genet 2015; 47: 1236–41.
6Anttila, V, Bulik-Sullivan, B, Finucane, HK, Walters, RK, Bras, J, et al. Analysis of shared heritability in common disorders of the brain. Science 2018; 360: eaap8757.
7Allardyce, J, Leonenko, G, Hamshere, M, Pardiñas, AF, Forty, L, Knott, S, et al. Association between schizophrenia-related polygenic liability and the occurrence and level of mood-incongruent psychotic symptoms in bipolar disorder. JAMA Psychiatry 2018; 75: 28–35.
8McLaughlin, RL, Schijven, D, van Rheenen, W, van Eijk, KR, O'Brien, M, Kahn, RS, et al. Genetic correlation between amyotrophic lateral sclerosis and schizophrenia. Nat Commun 2017; 8: 14774.
9Vassos, E, Di Forti, M, Coleman, J, Iyegbe, C, Prata, D, Euesden, J, et al. An examination of polygenic score risk prediction in individuals with first-episode psychosis. Biol Psychiatry 2017; 81: 470–7.
10Zilhão, NR, Abdellaoui, A, Smit, DJA, Cath, DC, Hottenga, JJ, Boomsma, DI. Polygenic prediction of obsessive compulsive symptoms. Mol Psychiatry 2018; 23: 168–9.
11Cross-Disorder Group of the Psychiatric Genomics Consortium. Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. Lancet 2013; 381: 1371–9.
12Bipolar Disorder and Schizophrenia Working Group of the Psychiatric Genomics Consortium. Genomic dissection of bipolar disorder and schizophrenia, including 28 subphenotypes. Cell 2018; 173: 1705–16.
13Turley, P, Walters, RK, Maghzian, O, Okbay, A, Lee, JJ, Fontana, MA, et al. Multi-trait analysis of genome-wide association summary statistics using MTAG. Nat Genet 2018; 9: 283.
14Lam, M, Trampush, JW, Yu, J, Knowles, E, Davies, G, Liewald, DC, et al. Large-scale cognitive GWAS meta-analysis reveals tissue-specific neural expression and potential nootropic drug targets. Cell Rep 2017; 21: 2597–613.
15Legge, SE, Hamshere, ML, Ripke, S, Pardinas, AF, Goldstein, JI, Rees, E, et al. Genome-wide common and rare variant analysis provides novel insights into clozapine-associated neutropenia. Mol Psychiatry 2017; 22: 1502–8.
16Amare, AT, Schubert, KO, Hou, L, Clark, SR, Papiol, S, Heilbronner, U, et al. Association of polygenic score for schizophrenia and HLA antigen and inflammation genes with response to lithium in bipolar affective disorder: a genome-wide association study. JAMA Psychiatry 2018; 75: 65–74.
17Lee, SH, Yang, J, Goddard, ME, Visscher, PM, Wray, NR. Estimation of pleiotropy between complex diseases using single-nucleotide polymorphism-derived genomic relationships and restricted maximum likelihood. Bioinformatics 2012; 28: 2540–2.
18Wray, NR, Goddard, ME, Visscher, PM. Prediction of individual genetic risk to disease from genome-wide association studies. Genome Res 2007; 17: 1520–8.
19The International Schizophrenia Consortium. Common polygenic variation contributes to risk of schizophrenia and bipolar disorder. Nature 2009; 460: 748–52.
20Schizophrenia Working Group of the Psychiatric Genomics Consortium. Biological insights from 108 schizophrenia-associated genetic loci. Nature 2014; 511: 421–7.
21Wray, NR, Yang, J, Hayes, BJ, Price, AL, Goddard, ME, Visscher, PM. Pitfalls of predicting complex traits from SNPs. Nat Rev Genet 2013; 14: 507–15.
22Peyrot, WJ, Milaneschi, Y, Abdellaoui, A, Sullivan, PF, Hottenga, JJ, Boomsma, DI, et al. Effect of polygenic risk scores on depression in childhood trauma. Br J Psychiatry 2014; 205: 113–9.
23O'Donovan, MC, Owen, MJ. The implications of the shared genetics of psychiatric disorders. Nat Med 2016; 22: 1214–9.
24Nordsletten, AE, Larsson, H, Crowley, JJ, Almqvist, C, Lichtenstein, P, Mataix-Cols, D. Patterns of nonrandom mating within and across 11 major psychiatric disorders. JAMA Psychiatry 2016; 73: 354–61.
25Han, B, Pouget, JG, Slowikowski, K, Stahl, E, Lee, CH, Diogo, D, et al. A method to decipher pleiotropy by detecting underlying heterogeneity driven by hidden subgroups applied to autoimmune and neuropsychiatric diseases. Nat Genet 2016; 48: 803–10.