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Intellectual asymmetry and genetic liability in first-degree relatives of probands with schizophrenia

Published online by Cambridge University Press:  02 January 2018

Eugenia Kravariti
Affiliation:
Department of Psychiatry Division of Psychological Medicine, Section of General Psychiatry, Institute of Psychiatry, King's College London, UK
Timothea Toulopoulou
Affiliation:
Department of Psychiatry Division of Psychological Medicine, Section of General Psychiatry, Institute of Psychiatry, King's College London, UK
Francesca Mapua-Filbey
Affiliation:
Department of Psychiatry Division of Psychological Medicine, Section of General Psychiatry, Institute of Psychiatry, King's College London, UK
Katja Schulze
Affiliation:
Department of Psychiatry Division of Psychological Medicine, Section of General Psychiatry, Institute of Psychiatry, King's College London, UK
Muriel Walshe
Affiliation:
Department of Psychiatry Division of Psychological Medicine, Section of General Psychiatry, Institute of Psychiatry, King's College London, UK
Pak Sham
Affiliation:
Department of Psychiatry Division of Psychological Medicine, Section of General Psychiatry, Institute of Psychiatry, King's College London, UK
Robin M. Murray
Affiliation:
Department of Psychiatry Division of Psychological Medicine, Section of General Psychiatry, Institute of Psychiatry, King's College London, UK
Colm McDonald
Affiliation:
Department of Psychiatry Division of Psychological Medicine, Section of General Psychiatry, Institute of Psychiatry, King's College London, UK
Corresponding
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Summary

Intellectual asymmetry with superiority of verbal skills to spatial skills frequently characterises patients with schizophrenia, but it is unclear whether this pattern also reflects genetic susceptibility to the disorder. We examined the association of a continuous measure of genetic liability to schizophrenia with Verbal-Spatial Contrast IQ (an index of intellectual asymmetry) in 108 first-degree relatives without psychosis of probands with schizophrenia. Higher genetic liability was significantly associated with greater intellectual asymmetry in favour of verbal skills. Intellectual asymmetry with a relative superiority of verbal skills to spatial skills represents a putative endophenotype of schizophrenia.

Type
Short Reports
Copyright
Copyright © 2006 The Royal College of Psychiatrists 

Footnotes

Declaration of Interest

None. Funding detailed in Acknowledgements.

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