Skip to main content
×
×
Home

Intellectual asymmetry and genetic liability in first-degree relatives of probands with schizophrenia

  • Eugenia Kravariti (a1), Timothea Toulopoulou (a1), Francesca Mapua-Filbey (a1), Katja Schulze (a1), Muriel Walshe (a1), Pak Sham (a1), Robin M. Murray (a1) and Colm McDonald (a1)...
Summary

Intellectual asymmetry with superiority of verbal skills to spatial skills frequently characterises patients with schizophrenia, but it is unclear whether this pattern also reflects genetic susceptibility to the disorder. We examined the association of a continuous measure of genetic liability to schizophrenia with Verbal-Spatial Contrast IQ (an index of intellectual asymmetry) in 108 first-degree relatives without psychosis of probands with schizophrenia. Higher genetic liability was significantly associated with greater intellectual asymmetry in favour of verbal skills. Intellectual asymmetry with a relative superiority of verbal skills to spatial skills represents a putative endophenotype of schizophrenia.

    • Send article to Kindle

      To send this article to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle. Find out more about sending to your Kindle.

      Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      Intellectual asymmetry and genetic liability in first-degree relatives of probands with schizophrenia
      Available formats
      ×
      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Dropbox.

      Intellectual asymmetry and genetic liability in first-degree relatives of probands with schizophrenia
      Available formats
      ×
      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Google Drive.

      Intellectual asymmetry and genetic liability in first-degree relatives of probands with schizophrenia
      Available formats
      ×
Copyright
Corresponding author
Dr Eugenia Kravariti, Institute of Psychiatry, Department of Psychiatry, Division of Psychological Medicine, Box 63, De Crespigny Park, London SE5 8AF, UK. Tel: +44 20 7848 0331, fax: +44 20 7701 9041, e-mail: e.kravariti@iop.kcl.ac.uk
Footnotes
Hide All

Declaration of Interest

None. Funding detailed in Acknowledgements.

Footnotes
References
Hide All
American Psychiatric Association (1994) Diagnostic and Statistical Manual of Mental Disorders (4th edn) (DSM-IV). Washington, DC: APA.
Amminger, G. P., Schlögelhofer, M., Lehner, T., et al (2000) Premorbid performance IQ deficit in schizophrenia. Acta Psychiatrica Scandinavica, 102, 414422.
Annett, M. (1970) A classification of hand preference by association analysis. British Journal of Psychology, 61, 303321.
Canavan, A. G. M. & Beckmann, J. (1993) Deriving principal-component IQ scores from the WAIS-R. British Journal of Clinical Psychology, 32, 8186.
Canavan, A. G. M., Dunn, G. & McMillan, T. M. (1986) Principal components of the WAIS-R. British Journal of Clinical Psychology, 25, 8186.
Endicott, J., Andreasen, N. & Spitzer, R. (1975) Family History Research Diagnostic Criteria. New York: Biometrics Research Division, New York State Psychiatric Institute.
Gottesman, I. I. & Gould, T. D. (2003) The endophenotype concept in psychiatry: etymology and strategic intentions. American Journal of Psychiatry, 160, 636645.
Heinrichs, R. & Zakzanis, K. (1998) Neurocognitive deficit in schizophrenia: a quantitative review of the evidence. Neuropsychology, 12, 426445.
Iverson, G. L., Woodward, T. S. & Green, P. (2001) Base rates of WAIS-RVIQ – PIQ differences in 1593 psychiatric inpatients. Journal of Clinical Psychology, 57, 15791587.
McDonald, C., Bullmore, E. T., Sham, P., et al (2004) Association of genetic risks for schizophrenia and bipolar disorder with specific and generic brain structural endophenotypes. Archives of General Psychiatry, 61, 974984.
Nurnberger, J., Blehar, M., Kaufmann, C., et al (1994) Diagnostic interview for genetic studies. Rationale, unique features, and training. NIMH Genetics Initiative. Archives of General Psychiatry, 51, 849859.
Office of Population Censuses and Surveys (1990) Standard Occupational Classification. Volume 3. London: Stationery Office.
Purcell, D. W., Lewine, R. R., Caudle, J., et al (1998) Sex differences in verbal IQ-performance IQ discrepancies among probands with schizophrenia and normal volunteers. Journal of Abnormal Psychology, 107, 161165.
Spitzer, R. & Endicott, J. (1978) Schedule for Affective Disorders and Schizophrenia – Lifetime Version. New York: New York State Psychiatric Institute.
Wechsler, D. (1981) Manual for Wechsler Adult Intelligence Scale – Revised. San Antonio, TX: Psychological Corporation.
Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

The British Journal of Psychiatry
  • ISSN: 0007-1250
  • EISSN: 1472-1465
  • URL: /core/journals/the-british-journal-of-psychiatry
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Metrics

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed

Intellectual asymmetry and genetic liability in first-degree relatives of probands with schizophrenia

  • Eugenia Kravariti (a1), Timothea Toulopoulou (a1), Francesca Mapua-Filbey (a1), Katja Schulze (a1), Muriel Walshe (a1), Pak Sham (a1), Robin M. Murray (a1) and Colm McDonald (a1)...
Submit a response

eLetters

No eLetters have been published for this article.

×

Reply to: Submit a response


Your details


Conflicting interests

Do you have any conflicting interests? *