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Medical disorders in people with recurrent depression

  • Anne Farmer (a1), Ania Korszun (a2), Michael J. Owen (a3), Nick Craddock (a3), Lisa Jones (a4), Ian Jones (a3), Jo Gray (a5), Richard J. Williamson (a5) and Peter McGuffin (a5)...
Abstract
Background

Few studies have examined the rates of physical disorders in those with recurrent depression.

Aims

To examine self-reported physical disorders in people with recurrent depression compared with a psychiatrically healthy control group.

Method

As part of a genetic case-control association study, 1546 participants with recurrent depression and 884 controls were interviewed about lifetime ever treatment for 16 different physical health disorders.

Results

The cases group had a significantly higher frequency of 14 physical disorders and more obesity than the control group. After controlling for age, gender, body mass index (BMI) and multiple testing, those in the cases group had significantly higher rates of gastric ulcer, rhinitis/hay fever, osteoarthritis, thyroid disease, hypertension and asthma.

Conclusions

People with recurrent depression show high rates of many common physical disorders. Although this can be partly explained by BMI, shared aetiological pathways such as dysfunction of the hypothalamic–pituitary axis may have a role.

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Copyright
Corresponding author
Dr Anne Farmer, Medical Research Council, Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK. Email: a.farmer@iop.kcl.ac.uk
Footnotes
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Declaration of interest

None.

Funding detailed in Acknowledgements.

Footnotes
References
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1 Patten, SB, Beck, CA, Kassan, A, Williams, JV, Barbui, C, Metz, LM. Long-term medical conditions and major depression: strength of association for specific conditions in the general population. Can J Psychiatry 2005; 50: 195202.
2 Paykel, ES, Brugha, T, Fryer, T. Size and burden of depressive disorders in Europe. Eur Neuropsychopharmacol 2005; 15: 411–23.
3 Korszun, A, Moskvina, V, Brewster, S, Craddock, N, Ferrero, F, Gill, M, Jones, IR, Jones, LA, Maier, W, Mors, O, Owen, MJ, Preisig, M, Reich, T, Rietschel, M, Farmer, A. Familiarity of symptom dimensions in depression. Arch Gen Psychiatry 2004; 61: 468–74.
4 Rijsdijk, FV, Sham, PC, Sterne, A, Purcell, S, McGuffin, P, Farmer, A, Goldberg, D, Mann, A, Cherny, SS, Webster, M, Ball, D, Eley, TC, Plomin, R. Life events and depression in a community sample of siblings. Psychol Med 2001; 31: 401–10.
5 Wing, JK, Babor, T, Brugha, T, Burke, J, Cooper, JE, Giel, R, Jablenski, A, Regier, D, Sartorius, N. SCAN: Schedules for Clinical Assessment in Neuropsychiatry. Arch Gen Psychiatry 1990; 47: 589–93.
6 American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders (4th edn, text revision) (DSM–IV–TR). APA, 2000.
7 World Health Organization. The ICD– 10 International Classification of Diseases, Chapter F: Mental and Behavioural Disorders. Diagnostic Criteria for Research. WHO, 1993.
8 Celik, C. Computer Assisted Personal Interviewing Application for the Schedules for the Clinical Assessment in Neuropsychiatry Version 2.1 and Diagnostic Algorithms for WHO ICD10 chapter V DCR and for Statistical Manual IV. Release 1 Ed. 1.0.3.5 Win9xNT. World Health Organization, 2003.
9 McGuffin, P, Katz, R, Aldrich, J. Past and Present State Examination: the assessment of lifetime ever psychopathology. Psychol Med 1986; 16: 461–5.
10 Beck, AT. The Beck Depression Inventory. Psychological Corporation, 1978.
11 McElroy, SL, Kotwal, R, Malhotra, S, Nelson, EB, Keck, PE, Nemeroff, CB. Are mood disorders and obesity related? A review for the mental health professional. J Clin Psychiatry 2004; 65: 634–51.
12 Faith, MS, Matz, PE, Jorge, MA. Obesity-depression associations in the population. J Psychosom Res 2002; 53: 935–42.
13 Taylor, WD, McQuoid, DR, Krishnan, KRR. Medical comorbidity in late-life depression. Int J Geriatr Psychiatry 2004; 19: 935–43.
14 Zielinski, TA, Brown, ES, Nejtek, VA, Khan, DA, Moore, JJ, Rush, AJ. Depression in asthma: prevalence and clinical implications Prim Care Companion J Clin Psychiatry 2004; 2: 153–8.
15 Hurwitz, EL, Morgenstern, H. Cross-sectional associations of asthma, hay fever and other allergies with major depression and low back pain among adults aged 20–39. Am J Epidemiol 1999; 150: 1107–16.
16 Thomsen, AF, Kvist, TK, Andersen, PK, Kessing, LV. Increased risk of developing affective disorder in patients with hypothyroidism: a register based study. Thyroid 2005; 15: 700–7.
17 Scalco, AZ, Scalco, MZ, Azul, JB, Lotufo Neto, F. Hypertension and depression. Clinics 2005; 60: 241–50.
18 Jonas, BS, Franks, P, Ingram, DD. Are symptoms of anxiety and depression risk factors for hypertension? Longitudinal evidence from the National Health and Nutrition Examination Survey I Epidemiologic Follow-up Study. Arch Family Med 1997; 6: 43–9.
19 Katon, W, Lin, EH, Kroenke, K. The association of depression and anxiety with medical symptom burden in patients with chronic medical illness. Gen Hosp Psychiatry 2007; 29: 147–55.
20 Centers for Disease Control and Prevention. Mental health in the United States: health risk behavior and conditions among persons with depression – New Mexico 2003. MMWR Morb Mortal Wkly Rep 2005; 7: 989–91.
21 Sherwood, E, Varghese, FP, McEwen, BS. Association of depression with medical illness: does cortisol play a role? Biol Psychiatry 2004; 55: 19.
22 Seckl, JR, Meaney, MJ. Glucocorticoid programming. Ann NY Acad Sci 2004; 1032: 6384.
23 Drapeau, V, Therrien, F, Richard, D, Tremblay, A. Is visceral obesity a physiological adaptation to stress? Panminerva Med 2003; 45: 189–95.
24 Amin, AR, Di Cesare, PE, Vyas, P, Attur, M, Tzeng, E, Billiar, TR, Stuchin, SA, Abramson, SB. The expression and regulation of nitric oxide synthase in human osteoarthritis-affected chondrocytes: evidence for up-regulated neuronal nitric oxide synthase. J Exp Med 1995; 182: 2097–102.
25 Nyklicek, I, Bosch, JA, Amerongen, AV. A generalised physiological hyperreactivity to acute stressors in hypertensives. Biol Psychol 2005; 70: 4451.
26 Sullivan, PF, Wilson, DA, Mulder, RT, Joyce, PR. The hypothalamic-pituitary-thyroid axis in major depression Acta Psychiatr Scand 1997; 95: 370–8.
27 Landis, RJ, Koch, GG. The measurement of observer agreement for categorical data. Biometrics 1977; 33: 159–74.
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Medical disorders in people with recurrent depression

  • Anne Farmer (a1), Ania Korszun (a2), Michael J. Owen (a3), Nick Craddock (a3), Lisa Jones (a4), Ian Jones (a3), Jo Gray (a5), Richard J. Williamson (a5) and Peter McGuffin (a5)...
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