Petersen, RC. Mild cognitive impairment as a diagnostic entity. J Intern Med
2004; 256: 183–94.
Lopez, OL, Kuller, LH, Becker, JT, Dulberg, C., Sweet, RA, Gach, HM et al. Incidence of dementia in mild cognitive impairment in the cardiovascular health study cognition study. Arch Neurol
2007; 64: 416–20.
Tschanz, JT, Welsh-Bohmer, KA, Lyketsos, CG, Corcoran, C., Green, RC, Hayden, K., et al. Conversion to dementia from mild cognitive disorder – the Cache County Study. Neurology
2006; 67: 229–34.
National Institute for Health and Clinical Excellence. Dementia: Supporting People with Dementia and their Carers in Health and Social Care. Clinical Guideline 42.
Jorm, AF, Korten, AE, Henderson, AS. The prevalence of dementia – a quantitative integration of the literature. Acta Psychiatr Scand
1987; 76: 465–79.
Raschetti, R., Albanese, E., Vanacore, N., Maggini, M.
Cholinesterase inhibitors in mild cognitive impairment: a systematic review of randomised trials. PLoS Med
2007; 4: e338.
Birks, J., Flicker, L.
Donepezil for mild cognitive impairment. Cochrane Database Syst Rev
2006; 3: CD006104.
Loy, C., Schneider, L.
Galantamine for Alzheimer's disease and mild cognitive impairment. Cochrane Database Syst Rev
2006; 1: CD001747.
Martin, M., Clare, L., Altgassen, AM, Cameron, MH, Zehnder, F.
Cognition-based interventions for healthy older people and people with mild cognitive impairment. Cochrane Database Syst Rev
2011; 1: CD006220.
Gates, NJ, Sachdev, PS, Fiatarone Singh, MA, Valenzuela, M.
Cognitive and memory training in adults at risk of dementia: a systematic review. BMC Geriatr
2011; 11: 55.
Jean, L., Bergeron, ME, Thivierge, S., Simard, M.
Cognitive intervention programs for individuals with mild cognitive impairment: systematic review of the literature. Am J Geriatr Psychiatry
2010; 18: 281–96.
Simon, SS, Yokomizo, JE, Bottino, CM. Cognitive intervention in amnestic mild cognitive impairment: a systematic review. Neurosci Biobehav Rev
2012; 36: 1163–78.
Stott, J., Spector, A.
A review of the effectiveness of memory interventions in mild cognitive impairment (MCI). Int Psychogeriatr
2011; 23: 526–38.
Unverzagt, FW, Kasten, L., Johnson, KE, Rebok, GW, Marsiske, M., Koepke, KM, et al. Effect of memory impairment on training outcomes in ACTIVE. J Internat Neuropsychol Soc
2007; 13: 953–60.
Doody, RS, Ferris, SH, Salloway, S., Sun, Y., Goldman, R., Watkins, WE, et al. Donepezil treatment of patients with MCI: a 48-week randomized, placebo-controlled trial. Neurology
2009; 72: 1555–61.
StatsDirect. Stats Direct Statistical Software.
Baker, LD, Frank, LL, Foster-Schubert, K., Green, PS, Wilkinson, CW, McTiernan, A., et al. Effects of aerobic exercise on mild cognitive impairment: a controlled trial. Arch Neurol
2010; 67: 71–9.
Barnes, DE, Yaffe, K., Belfor, N., Jagust, WJ, DeCarli, C., Reed, BR, et al. Computer-based cognitive training for mild cognitive impairment: results from a pilot randomized, controlled trial. Alzheimer Dis Assoc Disord
2009; 23: 205–10.
Buschert, VC, Friese, U., Teipel, SJ, Schneider, P., Merensky, W., Rujescu, D., et al. Effects of a newly developed cognitive intervention in amnestic mild cognitive impairment and mild Alzheimer's disease: a pilot study. J Alzheimers Dis
2011; 25: 679–94.
Kinsella, GJ, Mullaly, E., Rand, E., Ong, B., Burton, C., Price, S., et al. Early intervention for mild cognitive impairment: a randomised controlled trial. J Neurol Neurosurg Psychiatry
2009; 80: 730–6.
Newhouse, P., Kellar, K., Aisen, P., White, H., Wesnes, K., Coderre, E., et al. Nicotine treatment of mild cognitive impairment: a 6-month double-blind pilot clinical trial. Neurology
2012; 78: 91–101.
Koontz, J., Baskys, A.
Effects of galantamine on working memory and global functioning in patients with mild cognitive impairment: a double-blind placebo-controlled study. Am J Alzheimers Dis Other Demen
2005; 20: 295–302.
Nagaraja, D., Jayashree, S.
Randomized study of the dopamine receptor agonist piribedil in the treatment of mild cognitive impairment. Am J Psychiatry
2001; 158: 1517–9.
Troyer, AK, Murphy, KJ, Anderson, ND, Moscovitch, M., Craik, FI. Changing everyday memory behaviour in amnestic mild cognitive impairment: a randomised controlled trial. Neuropsychol Rehabil
2008; 18: 65–88.
Zhao, MX, Dong, ZH, Yu, ZH, Xiao, SY, Li, YM. Effects of Ginkgo biloba extract in improving episodic memory of patients with mild cognitive impairment: a randomized controlled trial [in Chinese]. Zhong Xi Yi Jie He Xue Bao
2012; 10: 628–34.
Busse, AL, Filho, JW, Magaldi, RM, Coelho, VA, Melo, AC, Betoni, RA, et al. Effects of resistance training exercise on cognitive performance in elderly individuals with memory impairment: results of a controlled trial. Einstein
2008; 6: 402–7.
Pelton, GH, Harper, OL, Tabert, MH, Sackeim, HA, Scarmeas, N., Roose, SP, et al. Randomized double-blind placebo-controlled donepezil augmentation in antidepressant-treated elderly patients with depression and cognitive impairment: a pilot study. Int J Geriatr Psychiatry
2008; 23: 670–6.
Li, H., Yao, MJ, Zhao, WM, Guan, J., Cai, LL, Cui, L.
A randomized, controlled, double-blind trial of Huannao Yicong capsule in senile patients with mild cognitive impairment [in Chinese]. Zhong Xi Yi Jie He Xue Bao
2008; 6: 25–31.
Chiu, CC, Su, KP, Cheng, TC, Liu, HC, Chang, CJ, Dewey, ME, et al. The effects of omega-3 fatty acids monotherapy in Alzheimer's disease and mild cognitive impairment: a preliminary randomized double-blind placebo-controlled study. Prog Neuropsychopharmacol Biol Psychiatry
2008; 32: 1538–44.
de Jager, CA, Oulhaj, A., Jacoby, R., Refsum, H., Smith, AD. Cognitive and clinical outcomes of homocysteine-lowering B-vitamin treatment in mild cognitive impairment: a randomized controlled trial. Int J Geriatr Psychiatry
2012; 27: 592–600.
Feldman, HH, Ferris, S., Winblad, B., Sfikas, N., Mancione, L., He, Y., et al. Effect of rivastigmine on delay to diagnosis of Alzheimer's disease from mild cognitive impairment: the InDDEx study. Lancet Neurol
2007; 6: 501–12.
Krikorian, R., Nash, TA, Shidler, MD, Shukitt-Hale, B., Joseph, JA. Concord grape juice supplementation improves memory function in older adults with mild cognitive impairment. Br J Nutr
2010; 103: 730–4.
Park, SK, Jung, IC, Lee, WK, Lee, YS, Park, HK, Go, HJ, et al. A combination of green tea extract and I-theanine improves memory and attention in subjects with mild cognitive impairment: a double-blind placebo-controlled study. J Med Food
2011; 14: 334–43.
Sinn, N., Milte, CM, Street, SJ, Buckley, JD, Coates, AM, Petkov, J., et al. Effects of n-3 fatty acids, EPA v. DHA, on depressive symptoms, quality of life, memory and executive function in older adults with mild cognitive impairment: a 6-month randomised controlled trial. Br J Nutr
2012; 107: 1682–93.
DeKosky, ST, Williamson, JD, Fitzpatrick, AL, Kronmal, RA, Ives, DG, Saxton, JA, et al. Ginkgo biloba for prevention of dementia: a randomized controlled trial. JAMA
2008; 300: 2253–62.
Fu, H., Wang, XM, Liu, GX. Effects of modified Wuzi Yanzong Granule on memory ability and volume of hippocampus measured by MRI in patients with mild cognitive impairment [in Chinese]. Zhongguo Zhong Xi Yi Jie He Za Zhi
2006; 26: 1066–9.
Tian, JZ, Zhu, AH, Zhong, J.
A follow-up study on a randomized, single-blind control of King's Brain pills in treatment of memory disorder in elderly people with MCI in a Beijing community [in Chinese]. Zhongguo Zhong Yao Za Zhi
2003; 28: 987–91.
van Uffelen, JG, Chinapaw, MJ, van, MW, Hopman-Rock, M.
Walking or vitamin B for cognition in older adults with mild cognitive impairment? A randomised controlled trial. Br J Sports Med
2008; 42: 344–51.
Luijpen, MW, Swaab, DF, Sergeant, JA, Scherder, EJ. Effects of transcutaneous electrical nerve stimulation (TENS) on self-efficacy and mood in elderly with mild cognitive impairment. Neurorehabil Neural Repair
2004; 18: 166–75.
Rondanelli, M., Opizzi, A., Faliva, M., Mozzoni, M., Antoniello, N., Cazzola, R., et al. Effects of a diet integration with an oily emulsion of DHA-phospholipids containing melatonin and tryptophan in elderly patients suffering from mild cognitive impairment. Nutr Neurosci
2012; 15: 46–54.
Scherder, EJ, Van, PJ, Deijen, JB, Van Der Knokke, S., Orlebeke, JF, Burgers, I., et al. Physical activity and executive functions in the elderly with mild cognitive impairment. Aging Ment Health
2005; 9: 272–80.
Suzuki, T., Shimada, H., Makizako, H., Doi, T., Yoshida, D., Tsutsumimoto, K., et al. Effects of multicomponent exercise on cognitive function in older adults with amnestic mild cognitive impairment: a randomized controlled trial. BMC Neurology
2012; 12: 128.
Mowla, A., Mosavinasab, M., Pani, A.
Does fluoxetine have any effect on the cognition of patients with mild cognitive impairment? A double-blind, placebo-controlled, clinical trial. J Clin Psychopharmacol
2007; 27: 67–70.
Gomez-Isla, T., Blesa, R., Boada, M., Clarimon, J., Del, ST, Domenech, G., et al. A randomized, double-blind, placebo controlled-trial of triflusal in mild cognitive impairment: the TRIMCI study. Alzheimer Dis Assoc Disord
2008; 22: 21–9.
Petersen, RC, Thomas, RG, Grundman, M., Bennett, D., Doody, R., Ferris, S., et al. Vitamin E and donepezil for the treatment of mild cognitive impairment. N Engl J Med
2005; 352: 2379–88.
Rapp, S., Brenes, G., Marsh, AP. Memory enhancement training for older adults with mild cognitive impairment: a preliminary study. Aging Ment Health
2002; 6: 5–11.
Rozzini, L., Costardi, D., Chilovi, BV, Franzoni, S., Trabucchi, M., Padovani, A.
Efficacy of cognitive rehabilitation in patients with mild cognitive impairment treated with cholinesterase inhibitors. Int J Geriatr Psychiatry
2007; 22: 356–60.
Salloway, S., Ferris, S., Kluger, A., Goldman, R., Griesing, T., Kumar, D., et al. Efficacy of donepezil in mild cognitive impairment: a randomized placebo-controlled trial. Neurology
2004; 63: 651–7.
Thal, LJ, Ferris, SH, Kirby, L., Block, GA, Lines, CR, Yuen, E., et al. A randomized, double-blind, study of rofecoxib in patients with mild cognitive impairment. Neuropsychopharmacology
2005; 30: 1204–15.
Zhou, RQ, Lin, SM, Yuan, Q.
Clinical study on effect of Shenyin Oral Liquid in treating mild cognitive impairment [in Chinese]. Zhongguo Zhong Xi Yi Jie He Za Zhi
2007; 27: 793–5.
Winblad, B., Gauthier, S., Scinto, L., Feldman, H., Wilcock, GK, Truyen, L. et al. Safety and efficacy of galantamine in subjects with mild cognitive impairment. Neurology
2008; 70: 2024–35.
Ferris, S., Schneider, L., Farmer, M., Kay, G., Crook, T.
A double-blind, placebo-controlled trial of memantine in age-associated memory impairment (memantine in AAMI). Int J Geriatr Psychiatry
2007; 22: 448–55.
Jean, L., Simard, M., Wiederkehr, S., Bergeron, ME, Turgeon, Y., Hudon, C., et al. Efficacy of a cognitive training programme for mild cognitive impairment: results of a randomised controlled study. Neuropsychol Rehabil
2010; 20: 377–405.
van Uffelen, JG, Chin, APMJ, Hopman-Rock, M., van Mechelen, W.
The effect of walking and vitamin B supplementation on quality of life in community-dwelling adults with mild cognitive impairment: a randomized, controlled trial. Qual Life Res
2007; 16: 1137–46.
Finn, M., McDonald, S.
Computerised cognitive training for older persons with mild cognitive impairment: a pilot study using a randomised controlled trial design. Brain Impair
2011; 12: 187–99.
Birks, J., Evans, JG. Ginkgo biloba for cognitive impairment and dementia. Cochrane Database Syst Rev
2009; 1: CD003120.
Snitz, BE, O'Meara, ES, Carlson, MC, Arnold, AM, Ives, DG, Rapp, SR, et al. Ginkgo biloba for preventing cognitive decline in older adults: a randomized trial. JAMA
2009; 302: 2663–70.
Weggen, S., Eriksen, JL, Das, P., Sagi, SA, Wang, R., Pietrzik, CU, et al. A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity. Nature
2001; 414: 212–6.
Forlenza, OV, Diniz, BS, Radanovic, M., Santos, FS, Talib, LL, Gattaz, WF. Disease-modifying properties of long-term lithium treatment for amnestic mild cognitive impairment: randomised controlled trial. Br J Psychiatry
2011; 198: 351–6.
Busse, A., Angermeyer, MC, Riedel-Heller, SG. Progression of mild cognitive impairment to dementia: a challenge to current thinking. Br J Psychiatry
2006; 189: 399–404.
Schneider, LS. The potential and limits for clinical trials for early Alzheimer's disease and some recommendations. J Nutr Health Aging
2010; 14: 295–8.