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Web-based intervention for depressive symptoms in adults with types 1 and 2 diabetes mellitus: a health economic evaluation

  • Stephanie Nobis (a1), David Daniel Ebert (a2), Dirk Lehr (a3), Filip Smit (a4), Claudia Buntrock (a5), Matthias Berking (a6), Harald Baumeister (a7), Frank Snoek (a8), Burkhardt Funk (a9) and Heleen Riper (a10)...

Web-based interventions are effective in reducing depression. However, the evidence for the cost-effectiveness of these interventions is scarce.


The aim is to assess the cost-effectiveness of a web-based intervention (GET.ON M.E.D.) for individuals with diabetes and comorbid depression compared with an active control group receiving web-based psychoeducation.


We conducted a cost-effectiveness analysis with treatment response as the outcome and a cost-utility analysis with quality-adjusted life-years (QALYs) alongside a randomised controlled trial with 260 participants.


At a willingness-to-pay ceiling of €5000 for a treatment response, the intervention has a 97% probability of being regarded as cost-effective compared with the active control group. If society is willing to pay €14 000 for an additional QALY, the intervention has a 51% probability of being cost-effective.


This web-based intervention for individuals with diabetes and comorbid depression demonstrated a high probability of being cost-effective compared with an active control group.

Declaration of interest

S.N., D.D.E., D.L., M.B. and B.F. are stakeholders of the Institute for Online Health Trainings, which aims to transfer scientific knowledge related to this research into routine healthcare.

Corresponding author
Correspondence: Stephanie Nobis, PhD, Wangerooger Straße 2, 49393 Lohne, Germany. Email:
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Web-based intervention for depressive symptoms in adults with types 1 and 2 diabetes mellitus: a health economic evaluation

  • Stephanie Nobis (a1), David Daniel Ebert (a2), Dirk Lehr (a3), Filip Smit (a4), Claudia Buntrock (a5), Matthias Berking (a6), Harald Baumeister (a7), Frank Snoek (a8), Burkhardt Funk (a9) and Heleen Riper (a10)...
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