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Zetidoline, A New Antipsychotic

First Controlled Trial in Acute Schizophrenia

Published online by Cambridge University Press:  29 January 2018

T. Silverstone ,
S. Levine ,
H. L. Freeman  and
A. Dubini
T. Silverstone
Affiliation:
Medical College of St. Bartholomew's Hospital, German Hospital, Ritson Road, London E8 IDF
S. Levine
Affiliation:
Oldham and District General Hospital, Oldham
H. L. Freeman
Affiliation:
Hope Hospital, Salford
A. Dubini
Affiliation:
Lepetit Research Laboratories, Milan, Italy
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Summary

Zetidoline (ZTD), a compound chemically unrelated to any available antipsychotic, with selective dopamine receptor-blocking properties, was compared with haloperidol (HLP) in a double-blind study on 56 in-patients who had either first episodes or acute relapses of schizophrenia. ZTD was found to be safe, as effective as HLP, and to produce significantly fewer extrapyramidal side-effects (EPS).

Type
Research Article
Information
The British Journal of Psychiatry , Volume 145 , Issue 3 , September 1984 , pp. 294 - 299
Copyright
Copyright © 1984 The Royal College of Psychiatrists 

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