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Alcohol use in schizophrenia: prevalence, patterns, correlates and clinical outcomes in Goa, India

  • Anil Rane (a1), Abhijit Nadkarni (a2), Jaiprada Kanekar (a1), Wenona Fernandes (a1), Hirabai A. Borker (a1) and Yvonne Pereira (a1)...
Abstract
Aims and method

To explore the patterns of alcohol consumption and its impact on clinical outcomes in schizophrenia in low- and middle-income countries. We performed a cross-sectional survey of 315 patients with schizophrenia and calculated the prevalence of alcohol consumption and alcohol use disorder. The patients' sociodemographic profiles and clinical outcomes, including Brief Psychiatric Rating Scale (BPRS) scores, were compared between abstainers and drinkers using the χ2- and t-tests.

Results

The 1-year prevalence of drinking, hazardous drinking and alcohol dependence was 16.8% (95% CI 12.9–21.4), 5.7% (95% CI 3.4–8.9) and 2.5% (95% CI 1.1–4.9), respectively. Male gender, single or post-marital status, higher education and being economically active were significantly associated with alcohol consumption. Alcohol drinkers were significantly more likely to be on combination psychotropics compared with abstainers. The mean total BPRS score was significantly lower in alcohol drinkers compared with abstainers. Drinking alcohol was associated with fewer deficit symptoms.

Clinical implications

Cultural settings have a significant impact on the prevalence of alcohol use disorder in schizophrenia.

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Copyright
This is an Open Access article, distributed under the terms of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Corresponding author
Anil Rane (dranilrane@rediffmail.com)
Footnotes
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Declaration of interest

None.

Footnotes
References
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1 Mueser, KT, Yarnold, PR, Levinson, DF, Singh, H, Bellack, AS, Kee, K, et al. Prevalence of substance abuse in schizophrenia: demographic and clinical correlates. Schizophr Bull 1990; 16: 3156.
2 Regier, DA, Farmer, ME, Rae, DS, Locke, BZ, Keith, SJ, Judd, LL, et al. Comorbidity of mental disorders with alcohol and other drug abuses. J Am Med Assoc 1990; 264: 2511–8.
3 Westermeyer, J. Schizophrenia and substance abuse. In Review of Psychiatry, Vol. 11) (eds Tasman, A, Riba, MR): 379401. American Psychiatric Press, 1992.
4 Drake, RE, Osher, FC, Noordsy, DL, Hurlbut, SC, Teague, GB, Beaudett, MS. Diagnosis of alcohol use disorders in schizophrenia, Schizophr Bull 1990; 16: 5767.
5 El-Guebaly, N, Hodgkins, DC. Schizophrenia and substance abuse: prevalence issues. Can J Psychiatry 1992; 37: 704–10.
6 Selzer, JA, Lieberman, JA. Schizophrenia and substance abuse. Psychiatr Clin North Am 1993; 16: 401–12.
7 Abou-Saleh, MT, Janca, A. The epidemiology of substance misuse and comorbid psychiatric disorders. Acta Neuropsychiatr 2004; 16: 38.
8 Schifano, F. European dimensions of dual diagnosis. In Dual Diagnosis: Substance Misuse and Psychiatric Disorders (ed. Rassool, GH): 5865. Blackwell Science, 2002.
9 Menezes, PR, Johnson, S, Thornicroft, G, Marshall, J, Prosser, D, Bebbington, P, et al. Drug and alcohol problems among individuals with severe mental illnesses in south London. Br J Psychiatry 1996; 168: 612–9.
10 Cantwell, R, Brewin, J, Glazebrook, C, Dalkin, T, Fox, R, Medley, I, et al. Prevalence of substance misuse in first-episode psychosis. Br J Psychiatry 1999; 174: 150–3.
11 Graham, HL, Maslin, J, Copello, A, Birchwood, M, Mueser, K, McGovern, D, et al. Drug and alcohol problems amongst individuals with severe mental health problems in an inner city area of the UK. Soc Psychiatry Psychiatr Epidemiol 2001; 36: 448–55.
12 Duke, PJ, Pantelis, C, Barnes, TR. South Westminster schizophrenia survey. Alcohol use and its relationship to symptoms, tardive dyskinesia and illness onset. Br J Psychiatry 1994; 164: 630–6.
13 Fowler, IL, Can, VJ, Carter, NT, Lewin, TJ. Patterns of current and lifetime substance use in schizophrenia. Schizophr Bull 1998; 24: 443–55.
14 Menezes, PR, Ratto, LR. Prevalence of substance misuse among individuals with severe mental illness in São Paulo. Soc Psychiatry Psychiatr Epidemiol 2004; 39: 212–7
15 Verma, SK, Subramaniam, M, Chong, S, Kua, EH. Substance abuse in schizophrenia: a Singapore perspective. Soc Psychiatry Psychiatr Epidemiol 2002; 37: 326–8.
16 Swofford, CD, Scheller-Gilkey, G, Miller, AH, Woolwine, B, Mance, R. Double jeopardy: schizophrenia and substance use. Am J Drug Alcohol Abuse 2000; 26: 343–53.
17 Inderbitzin, LB, Scheller-Gilkey, G, Lewine, RJ. A double-blind dosage reduction trial of fluphenazine decanoate in chronic, unstable schizophrenic patients. Am J Psychiatry 1994; 151: 1753–9.
18 Bowers, MB, Mazure, CM, Nelson, CJ, Jatlow, PI. Psychotogenic drug use and neuroleptic response. Schizophr Bull 1990; 16: 81–5.
19 Swofford, CD, Kasckow, JW, Scheller-Gilkey, G, Inderbitzin, LB. Substance use: a powerful predictor of relapse in schizophrenia. Schizophr Res 1996; 20: 145–51.
20 Haywood, TW, Kravitz, HM, Grossman, LS, Cavanaugh, JL Jr, Davis, JM, Lewis, DA. Predicting the revolving door phenomenon among patients with schizophrenic, schizoaffective, and affective disorders. Am J Psychiatry 1995; 152: 856–61.
21 Drake, RE, Wallach, MA. Substance abuse among the chronic mentally ill. Hosp Community Psychiatry 1989; 40: 1041–6.
22 Drake, RE, Osher, FC, Wallach, MA. Alcohol use and abuse in schizophrenia. J Nerv Ment Dis 1989; 177: 408–13.
23 Margolese, HC, Negrete, JC, Tempier, R, Gill, K. A 12-month prospective follow-up study of patients with schizophrenia-spectrum disorders and substance abuse: changes in psychiatric symptoms and substance use. Schizophr Res 2006; 83: 6575.
24 Cournos, F, Empfield, M, Horwath, E, McKinnon, K, Meyer, I, Schrage, H, et al. HIV prevalence among patients admitted to two psychiatric hospitals. Am J Psychiatry 1991; 148: 1225–9.
25 Rosenberg, SD, Goodman, LA, Osher, FC, Swartz, MS, Essock, SM, Butterfield, MI, et al. Prevalence of HIV, hepatitis B and hepatitis C in people with severe mental illness. Am J Public Health 2001; 91: 31–7.
26 Bartels, SJ, Drake, RE, McHugo, G. Alcohol abuse, depression, and suicidal behavior in schizophrenia. Am J Psychiatry 1992; 149: 394–5.
27 Swartz, MS, Swanson, JW, Hiday, V, Borum, R, Wagner, HR, Burns, BJ, et al. Violence and severe mental illness: the effects of substance abuse and non-adherence to medication. Am J Psychiatry 1998; 15: 226–31.
28 Goodman, LA, Salyers, MP, Mueser, KT, Rosenberg, SD, Swartz, M, Essock, SM, et al. Recent victimization in women and men with severe mental illness: prevalence and correlates. J Trauma Stress 2001; 14: 615–32.
29 Abram, K, Teplin, L. Co-occurring disorders among mentally ill jail detainees: implications for public policy. Am J Psychologist 1991; 46: 1036–44.
30 Caton, C, Shrout, P, Eagle, P, Opler, LA, Felix, A, Dominguez, B. Risk factors for homelessness among schizophrenic men: a case–control study. Am J Public Health 1994; 84: 265–70.
31 Dixon, L, McNary, S, Lehman, A. Substance abuse and family relationships of persons with severe mental illness. Am J Psychiatry 1995; 152: 456–8.
32 Brunette, MF, Mueser, KT, Xie, H, Drake, RE. Relationships between symptoms of schizophrenia and substance abuse. J Nerv Ment Dis 1997; 185: 1320.
33 Alterman, AI, Ayre, FR, Williford, WO. Diagnostic validation of conjoint schizophrenia and alcoholism. J Clin Psychiatry 1984; 5: 300–3.
34 Cuffel, BJ, Heithhoff, KA, Lawson, W. Correlates of patterns of substance abuse among patients with schizophrenia. Hosp Community Psychiatry 1993; 44: 247–51.
35 Serper, MR, Alpert, M, Richardson, NA, Dickson, S, Allen, MH, Werner, A. Clinical effects of recent cocaine use on patients with acute schizophrenia. Am J Psychiatry 1995; 152: 1464–9.
36 Rosenthal, RN, Hellerstein, KJ, Miner, CR. Positive and negative syndrome typology in schizophrenic patients with psychoactive substance use disorders. Compr Psychiatry 1994; 35: 91–8.
37 Sevy, S, Kay, SR, Opler, LA, van Praag, HM. Significance of cocaine history in schizophrenia. J Nerv Ment Dis 1990; 178: 642–8.
38 Xafenias, A, Diakogiannis, I, Iacovides, A, Fokas, K, Kaprinis, G. Factors affecting hospital length of stay: is substance use disorder one of them? A study in a Greek public psychiatric hospital. Am J Addict 2008; 17: 447–51.
39 Saunders, JB, Aasland, OG, Babor, TF, Fuente, JR, Grant, M. Development of the Alcohol Use Disorders Identification Test (AUDIT): WHO collaborative project on early detection of persons with harmful alcohol consumption – II. Addiction 1993; 88: 791804.
40 Babu, RS, Sengupta, SN. A study of problem drinkers in a general hospital. Indian J Psychiatry 1997; 39: 13–7.
41 Gaunekar, G, Patel, V, Rane, A. The impact and patterns of hazardous drinking amongst male industrial workers in Goa, India. Soc Psychiatry Psychiatr Epidemiol 2005; 40: 267–75.
42 Gaunekar, G, Patel, V, Jacob, KS, Vankar, G, Mehan, D, Rane, A, et al. Drinking patterns of hazardous drinkers: a multicenter study in India. In Moonshine Markets: Issues in Unrecorded Alcohol Beverage Production and Consumption (eds Howarth, A, Simpson, R): 122–41. Brunner-Routledge, 2004.
43 Silva, MC, Gaunekar, G, Patel, V, Kukalekar, DS, Fernandes, J. The prevalence and correlates of hazardous drinking in industrial workers: a study from Goa, India. Alcohol Alcohol 2003; 38: 7983.
44 World Health Organization. ICD-10 Classification of Mental and Behavioural Disorders, Diagnostic Criteria for Research. WHO, 1993.
45 Overall, JE, Gorham, DR. The brief psychiatric rating scale. Psychol Rep 1962; 10: 799812.
46 Nagaraj, AK, Pai, NB, Rao, S. A comparative study of sexual dysfunction involving risperidone, quetiapine and olanzapine. Indian J Psychiatry 2009; 51: 265–71.
47 D'Costa, G, Nazareth, I, Naik, D, Vaidya, R, Levy, G, Patel, V, et al. Harmful alcohol use in Goa, India, and its associations with violence: a study in primary care. Alcohol Alcohol 2007; 42: 131–7.
48 Ray, R, Mondal, AB, Gupta, K, Chatterjee, A, Bajaj, P. The Extent, Pattern and Trends of Drug Abuse in India: National Survey. United Nations Office on Drugs and Crimes and Ministry of Social Justice and Empowerment, Government of India, 2004.
49 Reddy, MV, Chandrashekar, CR. Prevalence of mental and behavioral disorders in India: a meta-analysis. Indian J Psychiatry 1998; 40: 149–57.
50 Mueser, KT, Yarnold, PR, Rosenberg, ST, Swett, C Jr, Miles, KM, Hill, D. Substance use disorder in hospitalised severely mentally ill psychiatric patients: prevalence, correlates and subgroups. Schizophr Bull 2000; 26: 179–92.
51 Hall, W, Teesson, M, Lynskey, M, Degenhardt, L. The 12-month prevalence of substance use and ICD-10 substance use disorders in Australian adults: findings from National Survey of Mental Health and Well Being. Addiction 1999; 94: 1541–50.
52 Fischer, EP, McSweeney, JC, Pyne, JM, Williams, DK, Naylor, AJ, Blow, FC, et al. Influence of family involvement and substance use on sustained utilisation of services for schizophrenia. Psychiatr Serv 2008; 59: 902–8.
53 Aich, TK, Sinha, VK, Khess, C, Singh, S. Substance abuse co-morbidity in schizophrenia: an in-patient study of course and outcome. Indian J Psychiatry 2005; 47: 33–8.
54 Blow, FC, Barry, KL, Bootsmiller, BJ, Copeland, LA, McCormick, R, Visnic, S. Longitudinal assessment of inpatient use and functioning of seriously mentally ill veterans with and without co-occurring substance use disorders. J Psychiatr Res 2008; 32: 311–9.
55 Arndt, S, Tyrrell, G, Flaum, M, Andreasen, NC Comorbidity of substance abuse and schizophrenia: the role of pre-morbid adjustment. Psychol Med 1992; 22: 379–88.
56 Dixon, L, Haas, G, Weiden, PJ, Sweeney, J, Frances, AJ. Drug abuse in schizophrenic patients: clinical correlates and reasons for use. Am J Psychiatry 1994; 148: 224–30.
57 Salyers, MP, Mueser, KT. Social functioning, psychopathology, and medication side effects in relation to substance use and abuse in schizophrenia. Schizophr Res 2001; 48: 109–23.
58 Potvin, S, Sepehry, A, Stip, E. A meta-analysis of negative symptoms in dual diagnosis schizophrenia. Psychol Med 2006; 36: 431–40.
59 Cohen, M, Klein, DF. Drug abuse in a young psychiatric population. Am J Orthopsychiatry 1970; 40: 448–55.
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Alcohol use in schizophrenia: prevalence, patterns, correlates and clinical outcomes in Goa, India

  • Anil Rane (a1), Abhijit Nadkarni (a2), Jaiprada Kanekar (a1), Wenona Fernandes (a1), Hirabai A. Borker (a1) and Yvonne Pereira (a1)...
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