Skip to main content Accessibility help
×
Home
Hostname: page-component-768ffcd9cc-6vg6l Total loading time: 0.168 Render date: 2022-11-30T23:34:35.960Z Has data issue: true Feature Flags: { "shouldUseShareProductTool": true, "shouldUseHypothesis": true, "isUnsiloEnabled": true, "useRatesEcommerce": false, "displayNetworkTab": true, "displayNetworkMapGraph": false, "useSa": true } hasContentIssue true

Heritability and Genome-Wide Linkage Scan of Subjective Happiness

Published online by Cambridge University Press:  21 February 2012

Meike Bartels*
Affiliation:
Department of Biological Psychology, VU University, Amsterdam, the Netherlands; EMGO+ Institute, VU University Medical Center, Amsterdam, the Netherlands. m.bartels@psy.vu.nl
Viatcheslav Saviouk
Affiliation:
Department of Biological Psychology, VU University, Amsterdam, the Netherlands.
Marleen H. M. de Moor
Affiliation:
Department of Biological Psychology, VU University, Amsterdam, the Netherlands.
Gonneke Willemsen
Affiliation:
Department of Biological Psychology, VU University, Amsterdam, the Netherlands.
Toos C. E. M. van Beijsterveldt
Affiliation:
Department of Biological Psychology, VU University, Amsterdam, the Netherlands.
Jouke-Jan Hottenga
Affiliation:
Department of Biological Psychology, VU University, Amsterdam, the Netherlands.
Eco J. C. de Geus
Affiliation:
Department of Biological Psychology, VU University, Amsterdam, the Netherlands.
Dorret I. Boomsma
Affiliation:
Department of Biological Psychology, VU University, Amsterdam, the Netherlands.
*
*Address for correspondence: Meike Bartels, PhD, Department of Biological Psychology, room 2B-47, 1081 BT Amsterdam, The Netherlands.

Abstract

HTML view is not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Causes of individual differences in happiness, as assessed with the Subjective Happiness Scale, are investigated in a large of sample twins and siblings from the Netherlands Twin Register. Over 12,000 twins and siblings, average age 24.7 years (range 12 to 88), took part in the study. A genetic model with an age by sex design was fitted to the data with structural equation modeling in Mx. The heritability of happiness was estimated at 22% for males and 41% in females. No effect of age was observed. To identify the genomic regions contributing to this heritability, a genome-wide linkage study for happiness was conducted in sibling pairs. A subsample of 1157 offspring from 441 families was genotyped with an average of 371 micro-satellite markers per individual. Phenotype and genotype data were analyzed in MERLIN with multipoint variance component linkage analysis and age and sex as covariates. A linkage signal (logarithm of odds score 2.73, empirical p value 0.095) was obtained at the end of the long arm of chromosome 19 for marker D19S254 at 110 cM. A second suggestive linkage peak was found at the short arm of chromosome 1 (LOD of 2.37) at 153 cM, marker D1S534 (empirical p value of .209). These two regions of interest are not overlapping with the regions found for contrasting phenotypes (such as depression, which is negatively associated with happiness). Further linkage and future association studies are warranted.

Type
Articles
Copyright
Copyright © Cambridge University Press 2010
You have Access
33
Cited by

Save article to Kindle

To save this article to your Kindle, first ensure coreplatform@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle.

Note you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Heritability and Genome-Wide Linkage Scan of Subjective Happiness
Available formats
×

Save article to Dropbox

To save this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you used this feature, you will be asked to authorise Cambridge Core to connect with your Dropbox account. Find out more about saving content to Dropbox.

Heritability and Genome-Wide Linkage Scan of Subjective Happiness
Available formats
×

Save article to Google Drive

To save this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you used this feature, you will be asked to authorise Cambridge Core to connect with your Google Drive account. Find out more about saving content to Google Drive.

Heritability and Genome-Wide Linkage Scan of Subjective Happiness
Available formats
×
×

Reply to: Submit a response

Please enter your response.

Your details

Please enter a valid email address.

Conflicting interests

Do you have any conflicting interests? *