Skip to main content
×
×
Home

Twins Early Development Study (TEDS): A Genetically Sensitive Investigation of Cognitive and Behavioral Development From Childhood to Young Adulthood

  • Claire M. A. Haworth (a1), Oliver S. P. Davis (a1) and Robert Plomin (a1)
Abstract

The Twins Early Development Study (TEDS) is a large longitudinal sample of twins born in England and Wales between 1994 and 1996. The focus of TEDS has been on cognitive and behavioral development, including difficulties in the context of normal development. TEDS began when multiple births were identified from birth records and the families were invited to take part in the study; 16,810 pairs of twins were originally enrolled in TEDS. More than 10,000 of these twin pairs remain enrolled in the study to date. DNA has been collected for more than 7,000 pairs, and genome-wide genotyping data for two million DNA markers are available for 3,500 individuals. The TEDS families have taken part in studies when the twins were aged 2, 3, 4, 7, 8, 9, 10, 12, 14, and 16 years of age. Data collection is currently underway to assess the adult destinations of the twins as they move from school to university and the workplace. Between January 2012 and December 2014, all of the TEDS twins will turn 18, and the study will transition to an adult sample. TEDS represents an outstanding resource for investigating the developmental effects of genes and environments on complex quantitative traits from childhood to young adulthood and beyond.

    • Send article to Kindle

      To send this article to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle. Find out more about sending to your Kindle.

      Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      Twins Early Development Study (TEDS): A Genetically Sensitive Investigation of Cognitive and Behavioral Development From Childhood to Young Adulthood
      Available formats
      ×
      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Dropbox.

      Twins Early Development Study (TEDS): A Genetically Sensitive Investigation of Cognitive and Behavioral Development From Childhood to Young Adulthood
      Available formats
      ×
      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Google Drive.

      Twins Early Development Study (TEDS): A Genetically Sensitive Investigation of Cognitive and Behavioral Development From Childhood to Young Adulthood
      Available formats
      ×
Copyright
Corresponding author
address for correspondence: Claire M. A. Haworth, Social, Genetic and Developmental Psychiatry Centre, P080, Institute of Psychiatry, King's College London, De Crespigny Park, London SE5 8AF, UK. E-mail: Claire.Haworth@kcl.ac.uk
References
Hide All
Arden, R., & Plomin, R. (2006). Sex differences in variance of intelligence across childhood. Personality and Individual Differences, 41, 3948.
Asbury, K., Almeida, D., Hibel, J., Harlaar, N., & Plomin, R. (2008). Clones in the classroom: A daily diary study of the nonshared environmental relationship between monozygotic twin differences in school experience and achievement. Twin Research and Human Genetics, 11, 586595.
Asbury, K., Wachs, T. D., & Plomin, R. (2005). Environmental moderators of genetic influence on verbal and nonverbal abilities in early childhood. Intelligence, 33, 643661.
Butcher, L. M., Davis, O. S. P., Craig, I. W., & Plomin, R. (2008). Genome-wide quantitative trait locus association scan of general cognitive ability using pooled DNA and 500K single nucleotide polymorphism microarrays. Genes, Brain and Behaviour, 7, 435446.
Dale, P. S., Harlaar, , Haworth, N., Plomin, C. M. A., & , R. (2010a). Two by two: A twin study of second-language acquisition. Psychological Science, 21 (5), 635640.
Dale, P. S., Harlaar, N., Hayiou-Thomas, M. E., & Plomin, R. (2010b). The etiology of diverse receptive language skills at 12 years. Journal of Speech, Language, and Hearing Research, 53, 982992.
Dale, P. S., Simonoff, E., Bishop, D. V. M., Eley, T. C., Oliver, B., Price, T. S., . . . Plomin, R. (1998). Genetic influence on language delay in two-year-old children. Nature Neuroscience, 1, 324328.
Davis, O. S. P., Butcher, L. M., Docherty, S. J., Meaburn, E. M., Curtis, C. J. C., Simpson, A., . . . Plomin, R. (2010). A three-stage genome-wide association study of general cognitive ability: Hunting the small effects. Behavior Genetics, 40, 759767.
Davis, O. S. P., Haworth, C. M. A., Lewis, C. M., & Plomin, R. (2012). Visual analysis of geocoded twin data puts nature and nurture on the map. Molecular Psychiatry, 17, 867874.
Davis, O. S. P., Haworth, C. M. A., & Plomin, R. (2009). Dramatic increase in heritability of cognitive development from early to middle childhood: An 8-year longitudinal study of 8,700 pairs of twins. Psychological Science, 20, 13011308.
Davis, O. S. P., Kovas, Y., Harlaar, N., Busfield, P., McMillan, A., Frances, J., . . . Plomin, R. (2008). Generalist genes and the Internet generation: Etiology of learning abilities by web testing at age 10. Genes, Brain and Behavior, 7, 455462.
Dionne, G., Dale, P. S., Boivin, M., & Plomin, R. (2003). Genetic evidence for bidirectional effects of early lexical and grammatical development. Child Development, 74, 394412.
Docherty, S. J., Davis, O. S. P., Kovas, Y., Meaburn, E. L., Dale, P. S., Petrill, S. A., . . . Plomin, R. (2010). A genome-wide association study identifies multiple loci associated with mathematics ability and disability. Genes, Brain and Behaviour, 9, 234237.
Eley, T. C., Bolton, D., O'Connor, T. G., Perrin, S., Smith, P., & Plomin, R. (2003). A twin study of anxiety-related behaviours in pre-school children. Journal of Child Psychology and Psychiatry, 44, 945960.
Gregory, A. M., Eley, T. C., O'Connor, T. G., & Plomin, R. (2004). Etiologies of associations between childhood sleep and behavioral problems in a large twin sample. Journal of the American Academic of Child and Adolescent Psychiatry, 43, 744751.
Greven, C. U., Asherson, P., Rijsdijk, F. V., & Plomin, R. (2011). A longitudinal twin study on the association between inattentive and hyperactive-impulsive ADHD symptoms. Journal of Abnormal Child Psychology, 39, 623632.
Greven, C. U., Harlaar, N., Kovas, Y., Chamorro-Premuzic, T., & Plomin, R. (2009). More than just IQ: School achievement is predicted by self-perceived abilities for genetic reasons. Psychological Science, 20, 753762.
Greven, C. U., Rijsdijk, F. V., Asherson, P., & Plomin, R. (2012). A longitudinal twin study on the association between ADHD symptoms and reading. Journal of Child Psychology and Psychiatry, 53 (3), 234242.
Hanscombe, K. B., Haworth, C. M. A., Davis, O. S. P., Jaffee, S. R., & Plomin, R. (2010). The nature (and nurture) of children's perceptions of family chaos. Learning and Individual Differences, 20, 549553.
Hanscombe, K. B., Trzaskowski, M., Haworth, C. M. A., Davis, O. S. P., Dale, P. S., & Plomin, R. (2012). Socioeconomic status (SES) and children's intelligence (IQ): In a UK-representative sample SES moderates the environmental, not genetic, effect on IQ. PLoS ONE, 7, e30320.
Harlaar, N., Butcher, L. M., Meaburn, E., Sham, P., Craig, I. W., & Plomin, R. (2005). A behavioural genomic analysis of DNA markers associated with general cognitive ability in 7-year-olds. Journal of Child Psychology and Psychiatry, 46, 10971107.
Harlaar, N., Dale, P. S., & Plomin, R. (2007). From learning to read to reading to learn: Substantial and stable genetic influence. Child Development, 78, 116131.
Haworth, C. M. A., Asbury, K., Dale, P. S., & Plomin, R. (2011). Added value measures in education show genetic as well as environmental influence. PLoS ONE, 6, e16006.
Haworth, C. M. A., Carnell, S., Meaburn, E. L., Davis, O. S. P., Plomin, R., & Wardle, J. (2008). Increasing heritability of BMI and stronger associations with the FTO gene over childhood. Obesity, 16, 26632668.
Haworth, C. M. A., Dale, P. S., & Plomin, R. (2009a). The etiology of science performance: Decreasing heritability and increasing importance of the shared environment from 9 to 12 years of age. Child Development, 80, 662673.
Haworth, C. M. A., Davis, O. S. P., Hanscombe, K. B., Kovas, Y., Dale, P. S., & Plomin, R. (in press). Understanding the science-learning environment: A genetically sensitive approach. Learning and Individual Differences. doi: http://dx.doi.org/10.1016/j.lindif.2012.07.018.
Haworth, C. M. A., Harlaar, N., Kovas, Y., Davis, O. S. P., Oliver, B. R., Hayiou-Thomas, M. E., . . . Plomin, R. (2007). Internet cognitive testing of large samples needed in genetic research. Twin Research and Human Genetics, 10, 554563.
Haworth, C. M. A., Kovas, Y., Harlaar, N., Hayiou-Thomas, M. E., Petrill, S. A., Dale, P. S., & Plomin, R. (2009b). Generalist genes and learning disabilities: A multivariate genetic analysis of low performance in reading, mathematics, language and general cognitive ability in a sample of 8000 12-year-old twins. Journal of Child Psychology and Psychiatry, 50, 13181325.
Haworth, C. M. A., & Plomin, R. (2010). Quantitative genetics in the era of molecular genetics: Learning abilities and disabilities as an example. Journal of the American Academy of Child and Adolescent Psychiatry, 49, 783793.
Hayiou-Thomas, M. E., Dale, P. S., & Plomin, R. (2012). The etiology of variation in language skills changes with development: A longitudinal twin study of language from 2 to 12 years. Developmental Science, 15, 233249.
Hayiou-Thomas, M. E., Kovas, Y., Harlaar, N., Plomin, R., Bishop, D. V. M., & Dale, P. S. (2006). Common aetiology for diverse language skills in 4½-year-old twins. Journal of Child Language, 33, 339368.
Iervolino, A. C., Hines, M., Golombok, S. E., Rust, J., & Plomin, R. (2005). Genetic and environmental influences on sex-typed behavior during the preschool years. Child Development, 76, 826840.
Knafo, A., & Plomin, R. (2006). Prosocial behavior from early to middle childhood: Genetic and environmental influences on stability and change. Developmental Psychology, 42, 771786.
Koeppen-Schomerus, G., Eley, T. C., Wolke, D., Gringras, P., & Plomin, R. (2000). The interaction of prematurity with genetic and environmental influences on cognitive development in twins. Journal of Pediatrics, 137, 527533.
Kovas, Y., Haworth, C. M. A., Dale, P. S., & Plomin, R. (2007a). The genetic and environmental origins of learning abilities and disabilities in the early school years. Monographs of the Society for Research in Child Development, 72, vii160.
Kovas, Y., Haworth, C. M. A., Harlaar, N., Petrill, S. A., Dale, P. S., & Plomin, R. (2007b). Overlap and specificity of genetic and environmental influences on mathematics and reading disability in 10-year-old twins. Journal of Child Psychology and Psychiatry, 48, 914922.
Larsson, H., Viding, E., Rijsdijk, F. V., & Plomin, R. (2008). Relationships between parental negativity and childhood antisocial behavior over time: A bidirectional effects model in a longitudinal genetically informative design. Journal of Abnormal Child Psychology, 36, 633645.
Loat, C. S., Haworth, C. M. A., Plomin, R., & Craig, I. W. (2008). A model incorporating potential skewed X-inactivation in MZ girls suggests that X-linked QTLs exist for several social behaviours including autism spectrum disorder. Annals of Human Genetics, 72, 742751.
Meaburn, E. L., Harlaar, N., Craig, I. W., Schalkwyk, L. C., & Plomin, R. (2008). Quantitative Trait Loci association scan of early reading disability and ability using pooled DNA and 100K SNP microarrays in a sample of 5760 children. Molecular Psychiatry, 13, 729740.
Oliver, B., Dale, P. S., & Plomin, R. (2004). Verbal and nonverbal predictors of early language problems: An analysis of twins in early childhood back to infancy. Journal of Child Language, 31, 609631.
Oliver, B., Dale, P. S., Saudino, K. J., Petrill, S. A., Pike, A., & Plomin, R. (2002). The validity of a parent-based assessment of cognitive abilities in 3-year olds. Early Child Development and Care, 172, 337348.
Oliver, B. R., Pike, A., & Plomin, R. (2008). Nonshared environmental influences on teacher-reported behaviour problems: Monozygotic twin differences in perceptions of the classroom. Journal of Child Psychology and Psychiatry, 49, 646653.
Oliver, B. R., & Plomin, R. (2007). Twins’ Early Development Study (TEDS): A multivariate, longitudinal genetic investigation of language, cognition and behavior problems from childhood through adolescence. Twin Research and Human Genetics, 10, 96105.
Petrill, S. A., Rempell, J., Oliver, B., & Plomin, R. (2002). Testing cognitive abilities by telephone in a sample of 6-to 8-year olds. Intelligence, 30, 353360.
Petrill, S. A., Saudino, K. S., Wilkerson, B., & Plomin, R. (2001). Genetic and environmental molarity and modularity of cognitive functioning in 2-year-old twins. Intelligence, 29, 3143.
Plomin, R. (2012). Child development and molecular genetics: 14 years later. Child Development. doi: 10.1111/j.1467-8624.2012.01757.x.
Plomin, R., Haworth, C. M. A., Meaburn, E. L., Price, T., Wellcome Trust Case Control Consortium 2, & Davis, O. S. P. (in press). Common DNA markers can account for more than half of the genetic influence on cognitive abilities. Psychological Science.
Plomin, R., Hill, L., Craig, I. W., McGuffin, P., Purcell, S., Sham, P., . . . Owen, M. J. (2001). A genome-wide scan of 1842 DNA markers for allelic associations with general cognitive ability: A five-stage design using DNA pooling and extreme selected groups. Behavior Genetics, 31, 497509.
Price, T. S., Freeman, B., Craig, I., Petrill, S. A., Ebersole, L., & Plomin, R. (2000). Infant zygosity can be assigned by parental report questionnaire data. Twin Research, 3, 129133.
Price, T. S., Grosser, T., Plomin, R., & Jaffee, S. R. (2010). Fetal genotype for the xenobiotic metabolizing enzyme NQO1 influences intrauterine growth among infants whose mothers smoked during pregnancy. Child Development, 81, 101114.
Robinson, E. B., Koenen, K. C., McCormick, M. C., Munir, K., Hallett, V., Happé, F., Plomin, R., & Ronald, A. (2011). Evidence that autistic traits show the same etiology in the general population and at the quantitative extremes (5%, 2.5% and 1%). Archives of General Psychiatry, 68, 11131121.
Ronald, A., Butcher, L. M., Docherty, S., Davis, O. S. P., Schalkwyk, L. C., Craig, I. W., & Plomin, R. (2010a). A genome-wide association study of social and non-social autistic-like traits in the general population using pooled DNA, 500K SNP microarrays and both community and diagnosed autism replication samples. Behavior Genetics, 40, 3145.
Ronald, A., Happe, F., Bolton, P., Butcher, L. M., Price, T. S., Wheelwright, S., . . . Plomin, R. (2006). Genetic heterogeneity between the three components of the autism spectrum: A twin study. Journal of the American Academy of Child and Adolescent Psychiatry, 45, 691699.
Ronald, A., Happé, F., Dworzynski, K., Bolton, P., & Plomin, R. (2010b). Exploring the relationship between prenatal and neonatal complications and later autistic-like features in a representative community sample of twins. Child Development, 81, 166182.
Saudino, K. J., Dale, P. S., Oliver, B., Petrill, S. A., Richardson, V., Rutter, M., . . . Plomin, R. (1998). The validity of parent-based assessment of the cognitive abilities of 2-year-olds. British Journal of Developmental Psychology, 16, 349363.
Saudino, K. J., Ronald, A., & Plomin, R. (2005). The etiology of behavior problems in 7-year-old twins: Substantial genetic influence and negligible shared environmental influence for parent ratings and ratings by same and different teachers. Journal of Abnormal Child Psychology, 33, 113130.
Spinath, F. M., Price, T. S., Dale, P. S., & Plomin, R. (2004). The genetic and environmental origins of language disability and ability. Child Development, 75, 445454.
Trouton, A., Spinath, F. M., & Plomin, R. (2002). Twins Early Development Study (TEDS): A multivariate, longitudinal genetic investigation of language, cognition and behavior problems in childhood. Twin Research, 5, 444448.
Trzaskowski, M., Zavos, H. M. S., Haworth, C. M. A, Plomin, R., & Eley, T. C. (2012). Stable genetic influence on anxiety-related behaviours across middle childhood. Journal of Abnormal Child Psychology, 40, 8594.
Viding, E., Blair, R. J. R., Moffitt, T. E., & Plomin, R. (2005). Evidence for substantial genetic risk for psychopathy in 7-year-olds. Journal of Child Psychology and Psychiatry, 46, 592597.
Viding, E., Hanscombe, K., Curtis, C., Davis, O. S. P., Meaburn, E. L., & Plomin, R. (2010). In search of genes associated with risk for psychopathic tendencies in children: A two-stage genome-wide association study of pooled DNA. Journal of Child Psychology and Psychiatry, 51, 780788.
Viding, E., Spinath, F. M., Price, T. S., Bishop, D. V. M., Dale, P. S., & Plomin, R. (2004). Genetic and environmental influence on language impairment in 4-year-old same-sex and opposite-sex twins. Journal of Child Psychology and Psychiatry, 45, 315325.
Walker, A., Maher, J., Coulthard, M., Goddard, E., & Thomas, M. (2001). Living in Britain: Results from the 2000/2001 General Household Survey. London: TSO.
Walker, S. O., Petrill, S. A., Spinath, F. M., & Plomin, R. (2004). Nature, nurture and academic achievement: A twin study of teacher assessments of 7-year-olds. British Journal of Educational Psychology, 74, 323342.
Wardle, J., Carnell, S., Haworth, C. M. A., & Plomin, R. (2008). Evidence for a strong genetic influence on childhood adiposity despite the force of the obesogenic environment. American Journal of Clinical Nutrition, 87, 398404.
Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

Twin Research and Human Genetics
  • ISSN: 1832-4274
  • EISSN: 1839-2628
  • URL: /core/journals/twin-research-and-human-genetics
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Keywords

Metrics

Altmetric attention score

Full text views

Total number of HTML views: 86
Total number of PDF views: 1018 *
Loading metrics...

Abstract views

Total abstract views: 1654 *
Loading metrics...

* Views captured on Cambridge Core between September 2016 - 22nd July 2018. This data will be updated every 24 hours.