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An unusual voltage-gated anion channel found in the cone cells of the chicken retina

Published online by Cambridge University Press:  02 June 2009

Martin Wilson  and
Evanna Gleason
Martin Wilson
Affiliation:
Department of Zoology, University of California, Davis
Evanna Gleason
Affiliation:
Department of Zoology, University of California, Davis
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Abstract

Using the whole-cell patch clamp technique, we have examined the voltage-gated currents present in adult chicken cone cells. When calcium and calcium-gated currents are blocked, hyperpolarizing voltage steps elicit slowly increasing inward currents as has been shown for photoreceptors in other species. Unlike the case for other species, chicken cones appear to lack the inward-rectifying cationic current Ih that contributes to the shaping of the photovoltage. Instead of Ih, these cones possess an anionic inward-rectifying current that in kinetics, activation range and probably function is remarkably similar to Ih. This anion channel is unusual in that both nitrate and acetate are more permeant than chloride ions.

Keywords

ChickenPhotoreceptorCone cellRetinaPatch clampAnion channelChloride channelInward rectifier
Type
Research Article
Information
Visual Neuroscience , Volume 6 , Issue 1 , January 1991 , pp. 19 - 23
Copyright
Copyright © Cambridge University Press 1991

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