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Antibodies to human leucocyte antigens indicate subpopulations of microglia in human retina

Published online by Cambridge University Press:  02 June 2009

P.L. Penfold ,
M.C. Madigan  and
J.M. Provis
P.L. Penfold
Affiliation:
Save Sight and Eye Health Institute, Department of Ophthalmology, University of Sydney
M.C. Madigan
Affiliation:
Save Sight and Eye Health Institute, Department of Ophthalmology, University of Sydney
J.M. Provis
Affiliation:
Save Sight and Eye Health Institute, Department of Ophthalmology, University of Sydney Department of Anatomy, University of Sydney
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Abstract

Monoclonal antibodies to human leucocyte antigens, including anti-CD45 and anti-CD68, have been used to describe microglia in flatmounts of normal adult human retina for the first time. Anti-CD45 (the leucocyte common antigen) intensely labeled large numbers of cells in a regular distribution across the retina; anti-CD68 and anti-macrophage antibodies labeled fewer cells with distinctive morphologies, suggesting the presence of subpopulations of microglia in the human retina expressing leucocyte antigens.

Keywords

Human retinaMicrogliaCD antigensSubpopulationsRetinal flatmounts
Type
Short Communications
Information
Visual Neuroscience , Volume 7 , Issue 4 , October 1991 , pp. 383 - 388
Copyright
Copyright © Cambridge University Press 1991

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