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Regulation of transcription factors by the epigallocatechin-3-gallate in poultry reared under heat stress

Published online by Cambridge University Press:  26 May 2016

K. SAHIN  and
M.O. SMITH
K. SAHIN*
Affiliation:
Department of Animal Nutrition, Faculty of Veterinary Science, Firat University, Elazig, Turkey
M.O. SMITH
Affiliation:
Department of Animal Science, The University of Tennessee, TN, USA
*
Corresponding author: nsahinkm@yahoo.com
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Abstract

High ambient temperature is associated with decreasing growth rate, egg production, feed efficiency, nutrient utilisation, egg quality and is a major problem resulting in extensive economic losses in poultry. Poultry reared under heat stress may exhibit various metabolic disorders caused by a chronic state of oxidative stress and inflammation. Recently, nuclear factor-erythroid 2-related factor 2 (Nrf2) has emerged as an agent that plays a significant role in cellular protection against oxidative stress and inflammation. The nuclear factor kappa-B (NF-κB) signalling pathway has been associated with enhanced inflammatory response and its activation has been significantly correlated with heat stress. These transcription factors when activated can regulate antioxidant and anti-inflammatory cellular responses leading to the expression of detoxifying enzymes. Studies have shown that NF-κB and Nrf2 expression can be modulated by several factors, such as bioactive compounds. Green tea contains many polyphenolic antioxidants including the catechin, epigallocatechin-3-gallate (EGCG). As bioactive compounds, supplementing EGCG in poultry diets may improve antioxidant status in poultry. EGCG modulates signalling pathways including the NF-κB and Nrf2 that regulate antioxidant and anti-inflammatory responses. This review aims to discuss the evidence to justify a recommendation of EGCG in heat stressed poultry as a non-pharmacological option to activate the NF-κB and Nrf2 pathways.

Keywords

heat stressEGCGantioxidantanti-inflammatorypoultry
Type
Reviews
Information
World's Poultry Science Journal , Volume 72 , Issue 2 , June 2016 , pp. 299 - 306
Copyright
Copyright © World's Poultry Science Association 2016 

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