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Therapeutic potential of nanotechnology in reproduction disorders and possible limitations

Published online by Cambridge University Press:  04 August 2023

Pedro Alves Aguiar Barroso ,
Danisvânia Ripardo Nascimento ,
Miguel F. De Lima Neto ,
Ernando Igo T. De Assis ,
Ciro Siqueira Figueira  and
José Roberto Viana Silva Open the ORCID record for José Roberto Viana Silva [Opens in a new window]
Pedro Alves Aguiar Barroso
Affiliation:
Laboratory of Biotechnology and Physiology of Reproduction (LABIREP), Federal University of Ceará – UFC, Sobral-CE, Brazil
Danisvânia Ripardo Nascimento
Affiliation:
Laboratory of Biotechnology and Physiology of Reproduction (LABIREP), Federal University of Ceará – UFC, Sobral-CE, Brazil
Miguel F. De Lima Neto
Affiliation:
Laboratory of Biotechnology and Physiology of Reproduction (LABIREP), Federal University of Ceará – UFC, Sobral-CE, Brazil Research Center of Animal Experimentation (NUPEX), Federal University of Ceará – UFC, Sobral-CE, Brazil
Ernando Igo T. De Assis
Affiliation:
Laboratory of Biotechnology and Physiology of Reproduction (LABIREP), Federal University of Ceará – UFC, Sobral-CE, Brazil Research Center of Animal Experimentation (NUPEX), Federal University of Ceará – UFC, Sobral-CE, Brazil
Ciro Siqueira Figueira
Affiliation:
Laboratory of Material Engineering and Simulation of Sobral (LEMSS), Federal University of Ceará – UFC, Sobral-CE, Brazil
José Roberto Viana Silva*
Affiliation:
Laboratory of Biotechnology and Physiology of Reproduction (LABIREP), Federal University of Ceará – UFC, Sobral-CE, Brazil
*
Corresponding author: José Roberto Viana Silva; Email: jrvsilva@ufc.br
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Summary

One of the prominent peculiarities of nanoparticles (NPs) is their ability to cross biological barriers. Therefore, the development of NPs with different properties has great therapeutic potential in the area of reproduction because the association of drugs, hormones and other compounds with NPs represents an alternative for delivering substances directly at a specific site and for treatment of reproductive problems. Additionally, lipid-based NPs can be taken up by the tissues of patients with ovarian failure, deep endometriosis, testicular dysfunctions, etc., opening up new perspectives for the treatment of these diseases. The development of nanomaterials with specific size, shape, ligand density and charge certainly will contribute to the next generation of therapies to solve fertility problems in humans. Therefore, this review discusses the potential of NPs to treat reproductive disorders, as well as to regulate the levels of the associated hormones. The possible limitations of the clinical use of NPs are also highlighted.

Keywords

EmbryoNanoparticlesOocyteSperm cellsUterus
Type
Review Article
Information
Zygote , Volume 31 , Issue 5 , October 2023 , pp. 433 - 440
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Copyright
© The Author(s), 2023. Published by Cambridge University Press

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