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A Novel Polymer-Synthesized Ceramic Composite Based System for Bone Repair: Osteoblast Growth on Scaffolds with Varied Calcium Phosphate Content

Published online by Cambridge University Press:  01 February 2011

Yusuf M. Khan ,
Dhirendra S. Katti  and
Cato T. Laurencin
Yusuf M. Khan
Affiliation:
School of Biomedical Engineering, Science, and Health Systems, Drexel University, Philadelphia, PA 19104.
Dhirendra S. Katti
Affiliation:
Department of Biological Sciences and Bioengineering, Indian Institute of Technology, Kanpur - 208016, India
Cato T. Laurencin
Affiliation:
Department of Orthopaedic Surgery, School of Medicine, The University of Virginia, Charlottesville, VA 22903 Department of Biomedical Engineering, The University of Virginia, Charlottesville, VA 22904 Department of Chemical Engineering, The University of Virginia, Charlottesville, VA 22904
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Abstract

Polymer/ceramic composite matrices for bone tissue engineering were constructed by synthesizing a poorly crystalline calcium phosphate within poly(lactide-co-glycolide) microspheres that were subsequently fused together to form 3-dimensional structures. Calcium ion dissolution from the composite matrices in simulated body fluid was examined over a 24 hour period. The initial 4 hour period showed an increase in calcium ion concentration, whereas, a decrease in calcium ion concentration was noted thereafter. This decrease in concentration coincided with the precipitation of calcium phosphate on the surface of the matrices. Osteoblast proliferation studies on composite matrices showed statistically significant increases in cell number throughout the 21 day time period. These data together suggest that the composite matrix acts as both a calcium ion donor for reprecipitation of calcium phosphate that may enhance osteointegration of the implant, and a suitable surface for osteoblast proliferation.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 845: Symposium AA – Nanoscale Materials Science in Biology and Medicine , 2004 , AA2.9
Copyright
Copyright © Materials Research Society 2005

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References

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