Hostname: page-component-848d4c4894-5nwft Total loading time: 0 Render date: 2024-05-11T14:36:32.159Z Has data issue: false hasContentIssue false
  • English
  • Français

The effects of selection at different ages for high and low body weight on the pattern of fat deposition in mice

Published online by Cambridge University Press:  14 April 2009

J. F. Hayes  and
J. C. McCarthy
J. F. Hayes
Affiliation:
Faculty of Agriculture, University College, Glasnevin, Dublin 9, Ireland
J. C. McCarthy
Affiliation:
Faculty of Agriculture, University College, Glasnevin, Dublin 9, Ireland
Rights & Permissions [Opens in a new window]

Summary

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Two pairs of lines of mice, selected for High and Low weight at 5 weeks of age (H5 and L5) and at 10 weeks of age (H10 and L10) over 15 generations, were compared with each other and an unselected control line (QC) at three different ages, i.e. at 5, 10 and 21 weeks of age. Differences in percentage fat between High and Low lines were small at 5 weeks, clearcut at 10 weeks and at 21 weeks the High lines were almost twice as fat as the Low ones. The H5 line was slightly fatter than the H10 line at all three ages and the L10 line was fatter than the L5 line at two ages. The developmental pattern of fat deposition was unaffected by selection for high or low weight at 5 weeks, i.e. the relationship between fat weight and carcass weight was similar in the H5, L5 and QC lines. Selection at 10 weeks affected the level of fat at low carcass weights and the relative rate at which fat was subsequently deposited. The different correlated responses resulting from selection at 5 and 10 weeks are explained in terms of genetic variation in (1) the rate of food consumption, (2) the efficiency of energy utilization for growth, and (3) the relative amount of fat deposited up to the age at selection.

Type
Research Article
Information
Genetics Research , Volume 27 , Issue 3 , June 1976 , pp. 389 - 403
Copyright
Copyright © Cambridge University Press 1976

References

REFERENCES

Biondini, P. E., Sutherland, T. M. & Havertand, L. H. (1968). Body composition of mice selected for rapid growth rate. Journal of Animal Science 27, 5–12.CrossRefGoogle ScholarPubMed
Clarke, J. N. (1969). Studies on the genetic control of growth in mice. Ph.D. thesis, University of Edinburgh.Google Scholar
Duncan, A. J. (1974). Quality Control and Industrial Statistics, 4th ed.Homewood, Illinois: Richard D. Irwin, Inc.Google Scholar
Eisen, E. J. (1974). The laboratory mouse as a mammalian model for the genetics of growth. Proceedings First World Congress on Genetics Applied to Livestock Production 1, 467–509.Google Scholar
Falconer, D. S. (1973). Replicated selection for body weight in mice. Genetical Besearch 22, 291–321.Google ScholarPubMed
Fowler, R. E. (1958). The growth and carcass composition of strains of mice selected for large and small body size. Journal of Agricultural Science 51, 137–148.CrossRefGoogle Scholar
Harvey, W. R. (1960). Least squares analysis of data. United States Department of Agriculture Publication, ARS-20–80.Google Scholar
Hill, W. G. (1971). Design and efficiency of selection experiments for estimating genetic parameters. Biometrics 27, 293–311.CrossRefGoogle ScholarPubMed
Hull, P. (1960). Genetic relations between carcass fat and body weight in mice. Journal of Agricultural Science 55, 317–321.CrossRefGoogle Scholar
Lang, B. J. & Legates, J. E. (1969). Rate, composition and efficiency of growth in mice selected for large and small body weight. Theoretical and Applied Genetics 39, 306–314.CrossRefGoogle ScholarPubMed
McCarthy, J. C. (1967). The effects of inbreeding on the components of litter size in mice. Genetical Research 10, 73–80.CrossRefGoogle ScholarPubMed
Roberts, R. C. (1961). The lifetime growth and reproduction of selected strains of mice. Heredity 16, 369–381.CrossRefGoogle Scholar
Roberts, R. C. (1965). Some contributions of the laboratory mouse to animal breeding research. Animal Breeding Abstracts 33, 339–353.Google Scholar
Timon, V. M. & Eisen, E. J. (1970). Comparisons of ad libitum and restricted feeding of mice selected and unselected for postweaning gain. 1. Growth, feed consumption and feed efficiency. Genetics 64, 41–57.CrossRefGoogle ScholarPubMed