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Bioactive Silk-Like Protein Polymer Films on Silicon Devices

Published online by Cambridge University Press:  15 February 2011

J. Philip Anderson ,
Susanne C. Nilsson ,
Rupak M. Rajachar ,
Randy Logan ,
Neil A. Weissman  and
David C. Martin
J. Philip Anderson
Affiliation:
Macromolecular Science and Engineering Center, The University of Michigan, College of Engineering, Ann Arbor
Susanne C. Nilsson
Affiliation:
Department of Materials Science and Engineering, Royal Institute of Technology, S-100 44 Stockholm, Sweden.
Rupak M. Rajachar
Affiliation:
Department of Materials Science and Engineering, The University of Michigan, College of Engineering, Ann Arbor, MI. 48104.
Randy Logan
Affiliation:
Department of Materials Science and Engineering, The University of Michigan, College of Engineering, Ann Arbor, MI. 48104.
Neil A. Weissman
Affiliation:
Department of Materials Science and Engineering, The University of Michigan, College of Engineering, Ann Arbor, MI. 48104.
David C. Martin
Affiliation:
Macromolecular Science and Engineering Center, The University of Michigan, College of Engineering, Ann Arbor Department of Materials Science and Engineering, The University of Michigan, College of Engineering, Ann Arbor, MI. 48104.
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Abstract

Coatings of genetically engineered protein polymers based on the crystalline segment of B. Mori silk fibroinand cell binding domains from extracellular matrix proteins (ProNectin™ by Protein Polymer Technologies, Inc.) were applied to bare silicon wafers used to mimic microcircuit devices. These silicon devices have applications in the stimulation and monitoring of central nervous system activity but need bioactive coatings for integration into nervous tissue. Gel point coating technology was developed by preparing solutions at the onset of phase separation in protein polymer/formic acid/ ethanol systems. Dipping silicon wafer substrates into such solutions produced homogeneous thin protein polymer coatings. Quench coating techniques that create rough surfaces in a controlled manner were explored by driving protein polymer solutions through different regions of the protein polymer/formic acid/methanol system before drying. Atomic force microscopy was used to characterize the protein films.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 330: Symposium S – Biomolecular Materials by Design , 1993 , 171
Copyright
Copyright © Materials Research Society 1994

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References

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