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Comparison of intranasal medication delivery devices before and after functional endoscopic sinus surgery using Phacon sinus surgery models

Published online by Cambridge University Press:  18 July 2023

Christoforos Constantinou Open the ORCID record for Christoforos Constantinou [Opens in a new window] ,
Darren Yap ,
Arbaaz Pervaiz ,
Fabrizio Bandino ,
Sanjeeva Jeyaretna ,
Pablo Martinez-Devesa  and
Ali Qureishi
Christoforos Constantinou*
Affiliation:
Department of ENT, Oxford University Hospitals NHS Foundation Trust, Oxford, UK
Darren Yap
Affiliation:
Department of ENT, Oxford University Hospitals NHS Foundation Trust, Oxford, UK
Arbaaz Pervaiz
Affiliation:
Department of ENT, Oxford University Hospitals NHS Foundation Trust, Oxford, UK
Fabrizio Bandino
Affiliation:
Department of ENT, Oxford University Hospitals NHS Foundation Trust, Oxford, UK
Sanjeeva Jeyaretna
Affiliation:
Department of Neurosurgery, Oxford University Hospitals NHS Foundation Trust, Oxford, UK
Pablo Martinez-Devesa
Affiliation:
Department of ENT, Oxford University Hospitals NHS Foundation Trust, Oxford, UK
Ali Qureishi
Affiliation:
Department of ENT, Oxford University Hospitals NHS Foundation Trust, Oxford, UK
*
Corresponding author: Christoforos Constantinou; Email: chconstantinou93@gmail.com
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Abstract

Objective

Functional endoscopic sinus surgery for chronic rhinosinusitis improves sinus drainage and intranasal medication delivery. This study compares medication delivery with commonly used devices in normal and altered anatomy (post functional endoscopic sinus surgery) using sinus surgery models (Phacon).

Methods

Medication delivery was simulated via nasal drops, nasal spray and an irrigation device (Neilmed Sinus Rinse). Coverage was then calculated from endoscopic pictures taken at various anatomical sites in the normal nose and post functional endoscopic sinus surgery.

Results

In the normal nose, nasal spray did not penetrate the sphenoid sinus, and drops bypassed the vestibule anteriorly. Neilmed Sinus Rinse provided superior coverage at the sphenoid site following sphenoidectomy and the frontal site following Draf III. After ethmoidectomy, nasal drops overall provided less coverage than the other methods.

Conclusion

Neilmed Sinus Rinse generally provided the best distribution, followed by the nasal spray and then nasal drops. The type and extent of surgery also affects medication delivery.

Keywords

Intranasal drug administrationparanasal sinusesnasal spraynasal irrigation
Type
Main Article
Information
The Journal of Laryngology & Otology , Volume 138 , Issue 3 , March 2024 , pp. 310 - 314
Copyright
Copyright © The Author(s), 2023. Published by Cambridge University Press on behalf of J.L.O. (1984) LIMITED

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Footnotes

Christoforos Constantinou takes responsibility for the integrity of the content of the paper

Presented at the Royal Society of Medicine ‘Thinking outside the box – medical innovation in the 21st century’ conference, 2 December 2022, London, UK, and at the British Academic Conference of Otolaryngology (‘BACO’) International meeting, 16 February 2023, Birmingham, UK.

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