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KIT and platelet-derived growth factor receptor α gene expression in laryngeal small cell carcinoma

Published online by Cambridge University Press:  11 June 2010

T Kanazawa ,
M Nokubi ,
K Takizawa ,
S Matsuzawa ,
A Shinnabe ,
H Mineta  and
Y Iino
T Kanazawa*
Affiliation:
Department of Otolaryngology, Jichi Medical University Saitama Medical Center, Japan
M Nokubi
Affiliation:
Department of Pathology, Jichi Medical University Saitama Medical Center, Japan
K Takizawa
Affiliation:
Department of Otolaryngology, Jichi Medical University Saitama Medical Center, Japan
S Matsuzawa
Affiliation:
Department of Otolaryngology, Jichi Medical University Saitama Medical Center, Japan
A Shinnabe
Affiliation:
Department of Otolaryngology, Jichi Medical University Saitama Medical Center, Japan
H Mineta
Affiliation:
Department of Otolaryngology/Head and Neck Surgery, Hamamatsu University School of Medicine, Japan
Y Iino
Affiliation:
Department of Otolaryngology, Jichi Medical University Saitama Medical Center, Japan
*
Address for correspondence: Dr Takeharu Kanazawa, Department of Otolaryngology, Head and Neck Surgery, Jichi Medical University Saitama Medical Center, 857-1 Amanuma, Omiya, Saitama City, Saitama, 330-8503Japan. Fax: + 81 48 648 5188 E-mail: kanatake@omiya.jichi.ac.jp
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Abstract

Objective:

Small cell carcinoma has the worst prognosis of all laryngeal neoplasms. In order to further characterise this tumour, with a view to development of new therapeutic approaches, we report the results of KIT gene and platelet-derived growth factor receptor α gene expression analysis, for two extremely rare cases of primary small cell carcinoma of the larynx.

Method:

Case reports, including immunohistochemical study, and review of the literature.

Results:

We present two patients with laryngeal small cell carcinoma, who died from tumour metastasis to the lungs and brain despite aggressive treatment. Immunohistochemical studies revealed positive reactions for KIT gene expression and platelet-derived growth factor α gene expression in patient one, and for KIT gene expression in patient two. Molecular genetic analysis, using polymerase chain reaction direct sequencing, identified no mutations of the KIT or platelet-derived growth factor receptor α genes.

Conclusion:

Although further investigation is necessary regarding KIT gene expression and platelet-derived growth factor receptor α gene expression in laryngeal small cell carcinoma, the reported results suggest that these genes may be significant in the development of molecular targeted therapy.

Keywords

Neuroendocrine TumorsHead And Neck NeoplasmsBiological TherapySmall Cell CarcinomaLarynxPlatelet-Derived Growth Factor Receptor AlphaKIT
Type
Clinical Records
Information
The Journal of Laryngology & Otology , Volume 124 , Issue 12 , December 2010 , pp. 1340 - 1343
Copyright
Copyright © JLO (1984) Limited 2010

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References

1Wenig, BM, Hyams, VJ, Heffner, DK. Moderately differentiated neuroendocrine carcinoma of the larynx. A clinicopathologic study of 54 cases. Cancer 1988;62:2658–763.0.CO;2-M>CrossRefGoogle ScholarPubMed
2Ferlito, A, Barnes, L, Rinaldo, A, Gnepp, DR, Milroy, CM. A review of neuroendocrine neoplasms of the larynx: update on diagnosis and treatment. J Laryngol Otol 1998;112:827–34CrossRefGoogle ScholarPubMed
3Renner, G. Small cell carcinoma of the head and neck: a review. Semin Oncol 2007;34:3–14Google Scholar
4Gnepp, DR. Small cell neuroendocrine carcinoma of the larynx. A critical review of the literature. ORL J Otorhinolaryngol Relat Spec 1991;53:210–19CrossRefGoogle ScholarPubMed
5Baugh, RF, Wolf, GT, McClatchey, KD. Small cell carcinoma of the head and neck. Head Neck Surg 1986;8:343–54CrossRefGoogle ScholarPubMed
6Piccart-Gebhart, MJ, Procter, M, Leyland-Jones, B, Goldhirsch, A, Untch, M, Smith, I et al. Trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer. N Engl J Med 2005;353:1659–72CrossRefGoogle ScholarPubMed
7Moriguchi, H, Kim, TY, Sato, C. Gefitinib for refractory advanced non-small-cell lung cancer. Lancet 2006;367:299–300Google Scholar
8Bonner, JA, Harari, PM, Giralt, J, Azarnia, N, Shin, DM, Cohen, RB et al. Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neck. N Engl J Med 2006;354:567–78CrossRefGoogle ScholarPubMed
9Yamamoto, R, Hosokawa, S, Yamatodani, T, Morita, S, Okamura, J, Mineta, H. Eight cases of neuroendocrine carcinoma of the head and neck [in Japanese]. Nippon Jibiinkoka Gakkai Kaiho 2008;111:517–22Google Scholar
10Aguilar, EA 3rd, Robbins, KT, Stephens, J, Dimery, IW, Batsakis, JG. Primary oat cell carcinoma of the larynx. Am J Clin Oncol 1987;10:26–32Google Scholar
11Ferlito, A, Pesavento, G, Recher, G, Caruso, G, Dal Fior, S, Montaguti, A et al. Long-term survival in response to combined chemotherapy and radiotherapy in laryngeal small cell carcinoma. Auris Nasus Larynx 1986;13:113–23CrossRefGoogle ScholarPubMed
12Galanis, E, Frytak, S, Lloyd, RV. Extrapulmonary small cell carcinoma. Cancer 1997;79:1729–36Google Scholar
13Cassier, PA, Dufresne, A, Arifi, S, El Sayadi, H, Labidi, I, Ray-Coquard, I et al. Imatinib mesilate for the treatment of gastrointestinal stromal tumour. Expert Opin Pharmacother 2008;9:1211–22CrossRefGoogle ScholarPubMed
14Fletcher, JA. Role of KIT and platelet-derived growth factor receptors as oncoproteins. Semin Oncol 2004;31:4–11Google Scholar
15Terada, T. Primary extragastrointestinal stromal tumor of the transverse mesocolon without c-kit mutations but with PDGFRA mutations. Med Oncol 2009;26:233–7CrossRefGoogle ScholarPubMed
16Terada, T. Primary small cell carcinoma of the mediastinum: a case report with immunohistochemical and molecular genetic analyses of KIT and PDGFRA genes. Med Oncol 2009;26:247–50CrossRefGoogle ScholarPubMed
17Benjamin, RS, Debiec-Rychter, M, Le Cesne, A, Sleijfer, S, Demetri, GD, Joensuu, H et al. Gastrointestinal stromal tumors II: medical oncology and tumor response assessment. Semin Oncol 2009;36:302–11Google Scholar
18Boldrini, L, Ursino, S, Gisfredi, S, Faviana, P, Donati, V, Camacci, T et al. Expression and mutational status of c-kit in small-cell lung cancer: prognostic relevance. Clin Cancer Res 2004;10:4101–8Google Scholar
19Sihto, H, Sarlomo-Rikala, M, Tynninen, O, Tanner, M, Andersson, LC, Franssila, K et al. KIT and platelet-derived growth factor receptor alpha tyrosine kinase gene mutations and KIT amplifications in human solid tumors. J Clin Oncol 2005;23:49–57CrossRefGoogle ScholarPubMed