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Interarytenoid botulinum toxin A injection for the treatment of vocal process granuloma

Published online by Cambridge University Press:  12 November 2019

A-L Hamdan ,
E Khalifee ,
H Jaffal  and
A Ghanem
A-L Hamdan*
Affiliation:
Department of Otorhinolaryngology Head and Neck Surgery, American University of Beirut Medical Center, Lebanon
E Khalifee
Affiliation:
Department of Otorhinolaryngology Head and Neck Surgery, American University of Beirut Medical Center, Lebanon
H Jaffal
Affiliation:
Department of Otorhinolaryngology Head and Neck Surgery, American University of Beirut Medical Center, Lebanon
A Ghanem
Affiliation:
Department of Otorhinolaryngology Head and Neck Surgery, American University of Beirut Medical Center, Lebanon
*
Author for correspondence: Dr Abdul-Latif Hamdan, Department of Otolaryngology Head and Neck Surgery, American University of Beirut Medical Center, PO Box 11-0236, Beirut, Lebanon E-mail: ah77@aub.edu.lb Fax: +961 1 350 000
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Abstract

Objectives

To report on the efficacy and adverse effects of interarytenoid botulinum toxin A injection for the treatment of vocal process granuloma.

Methods

A retrospective chart review was conducted of eight patients with vocal process granuloma resistant to anti-reflux therapy who underwent interarytenoid botulinum toxin A injection. The mean dosage of botulinum toxin A injected was 6.56 U.

Results

Fifty per cent of patients had complete regression of the lesion and 50 per cent had partial regression. The main side effects were breathiness (n = 4), voice breaks (n = 1) and aspiration (n = 1).

Conclusion

Interarytenoid botulinum toxin A injection for the treatment of vocal process granuloma is an effective mode of therapy, with transient vocal and swallowing side effects.

Keywords

VoiceGranulomaInjectionsBotulinum Toxin
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 133 , Issue 12 , December 2019 , pp. 1041 - 1045
Copyright
Copyright © JLO (1984) Limited, 2019

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Footnotes

Dr A-L Hamdan takes responsibility for the integrity of the content of the paper

References

1Ylitalo, R, Lindestad, PA. Laryngeal findings in patients with contact granuloma: a long-term follow-up study. Acta Otolaryngol 2000;120:655–9Google ScholarPubMed
2Farwell, D, Belafsky, P, Rees, C. An endoscopic grading system for vocal process granuloma. J Laryngol Otol 2008;122:1092–5CrossRefGoogle ScholarPubMed
3Altman, KW. Vocal fold masses. Otolaryngol Clin North Am 2007;40:1091–108CrossRefGoogle ScholarPubMed
4Havas, TE, Priestley, J, Lowinger, DS. A management strategy for vocal process granulomas. Laryngoscope 1999;109:301–6CrossRefGoogle ScholarPubMed
5Emami, AJ, Morrison, M, Rammage, L, Bosch, D. Treatment of laryngeal contact ulcers and granulomas: a 12-year retrospective analysis. J Voice 1999;13:612–17CrossRefGoogle ScholarPubMed
6Lee, SW, Hong, HJ, Choi, SH, Sun, DI, Park, YH, Lee, BJ et al. Comparison of treatment modalities for contact granuloma: a nationwide multicenter study. Laryngoscope 2014;124:1187–91CrossRefGoogle ScholarPubMed
7Karkos, PD, George, M, Van Der Veen, J, Atkinson, H, Dwivedi, RC, Kim, D et al. Vocal process granulomas: a systematic review of treatment. Ann Otol Rhinol Laryngol 2014;123:314–20CrossRefGoogle ScholarPubMed
8Hoffman, HT, Overholt, E, Karnell, M, McCulloch, TM. Vocal process granuloma. Head Neck 2001;23:1061–74CrossRefGoogle ScholarPubMed
9Carroll, TL, Rosen, CA. Trial vocal fold injection. J Voice 2010;24:494–8CrossRefGoogle ScholarPubMed
10de Lima Pontes, PA, De Biase, NG, Gadelha, ME. Clinical evolution of laryngeal granulomas: treatment and prognosis. Laryngoscope 1999;109:289–94CrossRefGoogle ScholarPubMed
11Hillel, AD, Maronian, NC, Robinson, L, Waugh, PF, Klotz, DA. Treatment of the interarytenoid muscle with botulinum toxin for laryngeal dystonia. Ann Otol Rhinol Laryngol 2004;113:341–8CrossRefGoogle ScholarPubMed
12Nasri, S, Sercarz, JA, McAlpin, T, Berke, GS. Treatment of vocal fold granuloma using botulinum toxin type A. Laryngoscope 1995;105:585–8CrossRefGoogle ScholarPubMed
13Orloff, LA, Goldman, SN. Vocal fold granuloma: successful treatment with botulinum toxin. Otolaryngol Head Neck Surg 1999;121:410–13CrossRefGoogle ScholarPubMed
14Pham, J, Yin, S, Morgan, M, Stucker, F, Nathan, CA. Botulinum toxin: helpful adjunct to early resolution of laryngeal granulomas. J Laryngol Otol 2004;118:781–5CrossRefGoogle ScholarPubMed
15Damrose, EJ, Damrose, JF. Botulinum toxin as adjunctive therapy in refractory laryngeal granuloma. J Laryngol Otol 2008;122:824–8CrossRefGoogle ScholarPubMed
16Yılmaz, T, Kayahan, B, Günaydın, RÖ, Kuşçu, O, Sözen, T. Botulinum toxin A for treatment of contact granuloma. J Voice 2016;30:741–3CrossRefGoogle ScholarPubMed
17Pham, Q, Campbell, R, Mattioni, J, Sataloff, R. Botulinum toxin injections into the lateral cricoarytenoid muscles for vocal process granuloma. J Voice 2018;32:363–6CrossRefGoogle ScholarPubMed
18Fink, DS, Achkar, J, Franco, RA, Song, PC. Interarytenoid botulinum toxin injection for recalcitrant vocal process granuloma. Laryngoscope 2013;123:3084–7CrossRefGoogle ScholarPubMed