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Cone synapses in macaque fovea: I. Two types of non-S cones are distinguished by numbers of contacts with OFF midget bipolar cells

Published online by Cambridge University Press:  28 January 2011

STAN SCHEIN ,
IVY TRAN NGO ,
TERESA M. HUANG ,
KARL KLUG ,
PETER STERLING  and
STEVE HERR
STAN SCHEIN*
Affiliation:
Department of Psychology, Franz Hall, University of California, Los Angeles, Los Angeles, California Brain Research Institute, University of California, Los Angeles, Los Angeles, California California NanoSystems Institute, University of California, Los Angeles, Los Angeles, California
IVY TRAN NGO
Affiliation:
Department of Psychology, Franz Hall, University of California, Los Angeles, Los Angeles, California
TERESA M. HUANG
Affiliation:
Department of Psychology, Franz Hall, University of California, Los Angeles, Los Angeles, California
KARL KLUG
Affiliation:
Brain Research Institute, University of California, Los Angeles, Los Angeles, California
PETER STERLING
Affiliation:
Department of Neuroscience, University of Pennsylvania, Philadelphia, Pennsylvania
STEVE HERR
Affiliation:
Department of Psychology, Franz Hall, University of California, Los Angeles, Los Angeles, California
*
*Address correspondence and reprint requests to: Stan Schein, Department of Psychology, Franz Hall, Mailcode 951563, University of California, Los Angeles, Los Angeles, CA 90095-1563. E-mail: schein@ucla.edu
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Abstract

L and M cones, divided into two groups by absorption spectra, have not been distinguished by structure. Here, we report what may be such a difference. We reconstructed the synaptic terminals of 16 non-S cones and the dendritic arbors of their ON and OFF midget bipolar cells from high-magnification electron micrographs of serial thin sections of a small region of macaque fovea. Each cone terminal contacted a similar number (~16) of invaginating central elements provided by its ON midget bipolar cell. By contrast, the numbers of connections between a cone terminal and its OFF midget bipolar cell were grouped into two clusters: 30–37 versus 43–50 basal contacts in the triad-associated position and 41–47 versus 61–74 Outer Densities within those basal contacts. The coefficients of variation of these distributions were all in the range of 10% or lower, characteristic of single populations. If these two clusters correspond to M- and L-cone circuits, the results reveal structural differences between M and L cones and between their corresponding OFF midget bipolar cells.

Keywords

PrimatePhotoreceptorRetinaRetinal bipolar cellVision
Type
Research Article
Information
Visual Neuroscience , Volume 28 , Issue 1 , January 2011 , pp. 3 - 16
Copyright
Copyright © Cambridge University Press 2011

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