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Brain activation alterations with adjunctive deep transcranial magnetic stimulation in obsessive-compulsive disorder: an fMRI study

Published online by Cambridge University Press:  10 May 2022

Sachin Reddy Open the ORCID record for Sachin Reddy [Opens in a new window] ,
Umesh Shreekantiah ,
Nishant Goyal  and
Chandramouli Roy
Sachin Reddy*
Affiliation:
Department of Psychiatry, Central Institute of Psychiatry, Ranchi, India
Umesh Shreekantiah
Affiliation:
Department of Psychiatry, Central Institute of Psychiatry, Ranchi, India
Nishant Goyal
Affiliation:
Department of Psychiatry, Central Institute of Psychiatry, Ranchi, India
Chandramouli Roy
Affiliation:
Department of Psychiatry, Central Institute of Psychiatry, Ranchi, India
*
* Author for correspondence: Sachin Reddy, KR Email: snsachinnandu@gmail.com
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Abstract

Background

Obsessive-compulsive disorder (OCD) is one of the most common neuropsychiatric disorders with lifetime prevalence higher than that of schizophrenia and bipolar disorders. Inadequate response to available pharmacological and psychotherapeutic interventions is common in OCD. Adjunctive brain stimulation methods to address the inadequate treatment response in OCD have found a special interest in research. This study aimed to examine the efficacy of adjunctive deep transcranial magnetic stimulation (dTMS) in ameliorating the symptoms of OCD and the effect of dTMS on activation of brain regions while performing the Stroop task using functional magnetic resonance imaging (fMRI).

Methods

A total of 41 patients were assessed for the study out of which 15 OCD patients received 10 sessions of high-frequency dTMS using the H7 coil to target the anterior cingulate cortex and the medial prefrontal cortex over a period of 2 weeks. The Yale-Brown Obsessive-Compulsive Scale, the Hamilton Anxiety Rating Scale, and the Hamilton Depression Rating Scale were used for the pre- and post-stimulation clinical assessment. fMRI was used to measure the activation of brain regions while performing the Stroop task.

Results

There was a significant improvement in the obsessive-compulsive, anxiety, and depressive symptoms after the 2 weeks of the dTMS treatment. A significant decrease in the activation of left caudate nucleus and adjacent white matter was noted while performing the Stroop task after the dTMS treatment.

Conclusion

The study provides preliminary evidence for functional correlates of effectiveness of dTMS as an adjunctive treatment modality for OCD.

Keywords

Deep TMSobsessive-compulsive disorderfMRInoninvasive brain stimulationH7 coilneuromodulationtranscranial magnetic stimulation
Type
Original Research
Information
CNS Spectrums , Volume 28 , Issue 3 , June 2023 , pp. 361 - 366
Copyright
© The Author(s), 2022. Published by Cambridge University Press

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Footnotes

The study was conducted at the K S Mani Centre for Cognitive Neurosciences and the fMRI Centre, Central Institute of Psychiatry, Ranchi, India.

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